Rapid and accurate determination of chlorpheniramine maleate, noscapine hydrochloride and guaiphenesin in binary mixtures by derivative spectrophotometry

Pappano, Nora B.; Micalizzi, Y. C. De; Debattista, Nora B.; Ferretti, F.H.

doi:10.1016/s0039-9140(96)02083-8

Cited by 33 publications

(10 citation statements)

References 5 publications

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“…Different methods have been developed for the detection and determination of noscapine in plasma, urine, and opium samples include corona discharge ion mobility spectrometry [6], LC-MS [7][8][9], HPLC-MS/MS [10,11], LLE-MS/MS [12], flow injection chemiluminescence [13], adsorptive differential pulse stripping voltammetry [14], capillary electrophoresis (CE) [15,16], ATR-FT-IR and FT-Raman spectroscopy [17], high performance liquid chromatography (HPLC) [18][19][20] and spectrophotometry [21,22].…”

Section: Introductionmentioning

confidence: 99%

Modified glassy carbon electrode with multiwall carbon nanotubes as a voltammetric sensor for determination of noscapine in biological and pharmaceutical samples

Rezaei

Zare

2008

Sensors and Actuators B: Chemical

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Section: Introductionmentioning

confidence: 99%

Modified glassy carbon electrode with multiwall carbon nanotubes as a voltammetric sensor for determination of noscapine in biological and pharmaceutical samples

Rezaei

Zare

2008

Sensors and Actuators B: Chemical

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“…It tends to emphasize delicate spectral features by representing them in a new way, allowing the resolution of multicomponent systems and minimizing the effect of spectral background interferences in pharmaceutical applications (Ojeda et al, 1995;Rojas et al, 1988). It has led to significant developments in the analysis of drugs in the presence of their degradation products or in multicomponent mixtures (Pappano et al, 1997). For linearity studies, different concentrations of each drug were scanned and epsilon values were calculated (Table 4).…”

Section: Resultsmentioning

confidence: 99%

Drug interaction studies of gliquidone with fexofenadine, cetirizine, and levocetirizine

et al. 2009

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Controlling blood sugar levels is crucial for diabetic patients and is managed through administration of drugs such as gliquidone. Coadministration of antidiabetic drugs with H 1 -receptor antagonists is common but is also a source of concern due to potential coadministered drug interaction, especially in patients prone to allergic disorders. In this work, we describe in vitro drug interactions of gliquidone with commonly coadministered H 1 -receptor antagonists (fexofenadine hydrochloride, cetirizine dihydrochloride, and levocetirizine dihydrochloride). These studies were performed at 37°C in different pH environments simulating human body compartments using UV spectrophotometry and high performance liquid chromatography (HPLC). It was observed that the percentage availability values of gliquidone and H 1 -receptor antagonists were not affected in the presence of each other. No significant difference between gliquidone and H 1 -receptor antagonists and no remarkable changes in availability values were observed when these interactions were studied using UV-visible and HPLC techniques. This study thus supports the safe coadministration of gliquidone and H 1 -receptor blockers as an effective diabetic health management regimen.

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“…Neither method is suitable for determining low levels of the alkaloid [6]. Other previously published analytical assays include high-performance liquid chromatography (HPLC) [7 -9], liquid chromatography [10,11] and spectrophotometry [6,12]. For practical applications, it is necessary to develop a simple and more sensitive method of noscapine determination.…”

Section: Introductionmentioning

confidence: 99%

PLS and PARAFAC applied to determination of noscapine in biological fluids by excitation-emission matrix fluorescence

Ниази

Yazdanipour

2007

Pharm Chem J

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A method for the direct determination of noscapine, an opium alkaloid, in biological fluids such as urine and human plasma has been developed using excitation-emission matrix fluorescence measurements and chemometrics techniques based on partial least squares (PLS) and parallel factor (PARAFAC) analysis. A two-factor PARAFAC trilinear model without restrictions was used in the data analysis. The excitation wavelength range was from 285 to 315 nm and the emission was recorded from 325 to 500 nm. The calibration graph was constructed using sixteen standard solutions in the concentration range from 0.50 to 21.00 mg/ml for noscapine. The capabilities of the method for the analysis were evaluated by determining noscapine in synthetic and real samples with satisfactory results. In addition, a PLS model was built at one excitation wavelength and used to determine noscapine in a series of synthetic and real samples. The accuracy of the proposed methods, evaluated through the root mean square error of prediction (RMSEP) for noscapine by PARAFAC and PLS models was 0.2375 and 0.4901, respectively. The best model was obtained using PARAFAC analysis. This result shows that molecular fluorescence spectroscopy can be used for the development of robust analytical methods for the direct determination of noscapine on a complex background such as urine and human plasma.

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Rapid and accurate determination of chlorpheniramine maleate, noscapine hydrochloride and guaiphenesin in binary mixtures by derivative spectrophotometry

Cited by 33 publications

References 5 publications

Modified glassy carbon electrode with multiwall carbon nanotubes as a voltammetric sensor for determination of noscapine in biological and pharmaceutical samples

Modified glassy carbon electrode with multiwall carbon nanotubes as a voltammetric sensor for determination of noscapine in biological and pharmaceutical samples

Drug interaction studies of gliquidone with fexofenadine, cetirizine, and levocetirizine

PLS and PARAFAC applied to determination of noscapine in biological fluids by excitation-emission matrix fluorescence

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