Rapid and cost-effective benchtop microfabrication of disposable carbon-based electrochemical microfluidic devices

Hernández-Rodríguez, Juan F.; Rojas, Daniel; Escarpa, Alberto

doi:10.1016/j.snb.2020.128679

Cited by 20 publications

(11 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…S7a, to use LCNFs as a RE results in a cathodic shift for ferro/ferricyanide, approx. 200 mV, in comparison to the CV obtained from Ag/AgCl RE which is similar to using microband carbon strip as a RE reported by Escarpa's group [30]. However, when measuring dopamine solution, the peak potentials obtained from LCNF RE exhibited only a slight deviation in comparison to using Ag/AgCl RE (Fig.…”

Section: Investigation Of the Reliability And Stability Of Lcnfs As A...supporting

confidence: 86%

Freestanding 3D-interconnected carbon nanofibers as high-performance transducers in miniaturized electrochemical sensors

2022

View full text Add to dashboard Cite

Abstract3D-carbon nanomaterials have proven to be high-performance transducers in electrochemical sensors but their integration into miniaturized devices is challenging. Herein, we develop printable freestanding laser-induced carbon nanofibers (f-LCNFs) with outstanding analytical performance that furthermore can easily allow such miniaturization through a paper-based microfluidic strategy. The f-LCNF electrodes were generated from electrospun polyimide nanofibers and one-step laser carbonization. A three-electrode system made of f-LCNFs exhibited a limit of detection (LOD) as low as 1 nM (S/N = 8) for anodic stripping analysis of silver ions, exhibiting the peak at ca. 100 mV vs f-LCNFs RE, without the need of stirring. The as-described system was implemented in miniaturized devices via wax-based printing, in which their electroanalytical performance was characterized for both outer- and inner-sphere redox markers and then applied to the detection of dopamine (the peak appeared at ca. 200 mV vs f-LCNFs RE) with a remarkable LOD of 55 pM. When modified with Nafion, the f-LCNFs were highly selective to dopamine even against high concentrations of uric and ascorbic acids. Especially the integration into closed microfluidic systems highlights the strength 3D porous structures provides excellent analytical performance paving the way for their translation to affordable lab-on-a-chip devices where mass-production capability, unsophisticated fabrication techniques, transfer-free, and customized electrode designs can be realized. Graphical abstract

show abstract

Section: Investigation Of the Reliability And Stability Of Lcnfs As A...supporting

confidence: 86%

Freestanding 3D-interconnected carbon nanofibers as high-performance transducers in miniaturized electrochemical sensors

2022

View full text Add to dashboard Cite

show abstract

“…In this method, each channel layer was formed bonding with each other by a toner or double-sided adhesive (DSA). These overlapping channels increase the interface area between the two fluids. − …”

mentioning

confidence: 99%

Pump-Free Microfluidic Device for the Electrochemical Detection of α₁-Acid Glycoprotein

et al. 2021

Self Cite

View full text Add to dashboard Cite

α1-Acid glycoprotein (AGP) is a glycoprotein present in serum, which is associated with the modulation of the immune system in response to stress or injuries, and a biomarker for inflammatory diseases and cancers. Here, we propose a pump-free microfluidic device for the electrochemical determination of AGP. The microfluidic device utilizes capillary-driven flow and a passive mixing system to label the AGP with the Os (VI) complex (an electrochemical tag) inside the main channel, before delivering the products to the electrode surface. Furthermore, thanks to the resulting geometry, all the analytical steps can be carried out inside the device: labeling, washing, and detection by adsorptive transfer stripping square wave voltammetry. The microfluidic device exhibited a linear range from 500 to 2000 mg L–1 (R 2 = 0.990) and adequate limit of detection (LOD = 231 mg L–1). Commercial serum samples were analyzed to demonstrate the success of the method, yielding recoveries around 83%. Due to its simplicity, low sample consumption, low cost, short analysis time, disposability, and portability, the proposed method can serve as a point-of-care/need testing device for AGP.

show abstract

“…Hence, that instrumentation is being replaced by microcontroller-based or even wearable portable hand-held instrumentation, capable of performing measurements outside the lab without losing performance . Besides, new developments in rapid prototyping techniques have successfully brought a wide range of low-cost and high-throughput microfabrication approaches from clean rooms to laboratory settings, which can boost the throughput in the development of these devices. − On the other hand, microfluidics, the science of handling liquids through micrometer size channels, is also used in analytical chemistry due to low-sample and reagent consumption, short analysis time, and the analytical operations that can be performed inside the channels (i.e., mixing, extraction, or incubation of reactions). Due to the straightforward miniaturization of electrodes, they can be easily placed at the microchannels.…”

mentioning

confidence: 99%

Electrochemical Sensing Directions for Next-Generation Healthcare: Trends, Challenges, and Frontiers

2020

Self Cite

View full text Add to dashboard Cite

Rapid and cost-effective benchtop microfabrication of disposable carbon-based electrochemical microfluidic devices

Cited by 20 publications

References 23 publications

Freestanding 3D-interconnected carbon nanofibers as high-performance transducers in miniaturized electrochemical sensors

Freestanding 3D-interconnected carbon nanofibers as high-performance transducers in miniaturized electrochemical sensors

Pump-Free Microfluidic Device for the Electrochemical Detection of α₁-Acid Glycoprotein

Electrochemical Sensing Directions for Next-Generation Healthcare: Trends, Challenges, and Frontiers

Contact Info

Product

Resources

About

Rapid and cost-effective benchtop microfabrication of disposable carbon-based electrochemical microfluidic devices

Cited by 20 publications

References 23 publications

Freestanding 3D-interconnected carbon nanofibers as high-performance transducers in miniaturized electrochemical sensors

Freestanding 3D-interconnected carbon nanofibers as high-performance transducers in miniaturized electrochemical sensors

Pump-Free Microfluidic Device for the Electrochemical Detection of α1-Acid Glycoprotein

Electrochemical Sensing Directions for Next-Generation Healthcare: Trends, Challenges, and Frontiers

Contact Info

Product

Resources

About

Pump-Free Microfluidic Device for the Electrochemical Detection of α₁-Acid Glycoprotein