Rapid and Extensive Collapse from Electrically Responsive Macroporous Hydrogels

Kennedy, Stephen; Bencherif, Sidi A.; Norton, Daniel; Weinstock, L. A.; Mehta, Manav; Mooney, David J.

doi:10.1002/adhm.201300260

Cited by 42 publications

(40 citation statements)

References 29 publications

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“…Incorporation of iron oxide particles into an alginate hydrogel with micropores, for example, allows the material network to deform in a magnetic field, leading to convection in the device and accelerated release of factor (95). Electrically responsive hydrogels with macropores can similarly undergo collapse under an electrical field to enhance convective release of factors (96). These approaches may be useful for inducing delayed or precisely timed release of anti-inflammatory cytokines, since an initial inflammatory reaction is believed essential for the onset of angiogenesis.…”

Section: Directing Inflammationmentioning

confidence: 99%

Boon and Bane of Inflammation in Bone Tissue Regeneration and Its Link with Angiogenesis

Schmidt‐Bleek

Kwee²,

Mooney³

et al. 2015

Tissue Engineering Part B: Reviews

150

131

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Delayed healing or nonhealing of bone is an important clinical concern. Although bone, one of the two tissues with scar-free healing capacity, heals in most cases, healing is delayed in more than 10% of clinical cases. Treatment of such delayed healing condition is often painful, risky, time consuming, and expensive. Tissue healing is a multistage regenerative process involving complex and well-orchestrated steps, which are initiated in response to injury. At best, these steps lead to scar-free tissue formation. At the onset of healing, during the inflammatory phase, stationary and attracted macrophages and other immune cells at the fracture site release cytokines in response to injury. This initial reaction to injury is followed by the recruitment, proliferation, and differentiation of mesenchymal stromal cells, synthesis of extracellular matrix proteins, angiogenesis, and finally tissue remodeling. Failure to heal is often associated with poor revascularization. Since blood vessels mediate the transport of circulating cells, oxygen, nutrients, and waste products, they appear essential for successful healing. The strategy of endogenous regeneration in a tissue such as bone is interesting to analyze since it may represent a blueprint of successful tissue formation. This review highlights the interdependency of the time cascades of inflammation, angiogenesis, and tissue regeneration. A better understanding of these inter-relations is mandatory to early identify patients at risk as well as to overcome critical clinical conditions that limit healing. Instead of purely tolerating the inflammatory phase, modulations of inflammation (immunomodulation) might represent a valid therapeutic strategy to enhance angiogenesis and foster later phases of tissue regeneration.

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Section: Directing Inflammationmentioning

confidence: 99%

Boon and Bane of Inflammation in Bone Tissue Regeneration and Its Link with Angiogenesis

Schmidt‐Bleek

Kwee²,

Mooney³

et al. 2015

Tissue Engineering Part B: Reviews

150

131

View full text Add to dashboard Cite

show abstract

“…One of the challenges in scaffold design is in ensuring good mechanical structure and properties, rich active groups, as well as excellent biocompatibility and biodegradability. In addition, the design of biomaterials should mimic the physical characteristics and biological attributes of natural extracellular matrix (ECM) as much as possible ( Bencherif et al, 2012 ; Bencherif, Braschler & Renaud, 2013 ; Kennedy et al, 2014 ; Bencherif et al, 2015 ; Xiao et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Preparation and characteristics of gelatin sponges crosslinked by microbial transglutaminase

Long¹,

Xiao

et al. 2017

PeerJ

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Microbial transglutaminase (mTG) was used as a crosslinking agent in the preparation of gelatin sponges. The physical properties of the materials were evaluated by measuring their material porosity, water absorption, and elastic modulus. The stability of the sponges were assessed via hydrolysis and enzymolysis. To study the material degradation in vivo, subcutaneous implantations of sponges were performed on rats for 1–3 months, and the implanted sponges were analyzed. To evaluate the cell compatibility of the mTG crosslinked gelatin sponges (mTG sponges), adipose-derived stromal stem cells were cultured and inoculated into the scaffold. Cell proliferation and viability were measured using alamarBlue assay and LIVE/DEAD fluorescence staining, respectively. Cell adhesion on the sponges was observed by scanning electron microscopy (SEM). Results show that mTG sponges have uniform pore size, high porosity and water absorption, and good mechanical properties. In subcutaneous implantation, the material was partially degraded in the first month and completely absorbed in the third month. Cell experiments showed evident cell proliferation and high viability. Results also showed that the cells grew vigorously and adhered tightly to the sponge. In conclusion, mTG sponge has good biocompatibility and can be used in tissue engineering and regenerative medicine.

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“…Moreover, they have the advantages of being able to accommodate a large quantity of drug and achieve multiple dosing after a single administration through repeated triggering. Polymeric systems for triggerable drug delivery such as ferrogels, polyelectrolyte hydrogels, and light‐sensitive matrices have been studied. Drug release from these systems could be accelerated through mechanisms including ultrasound/light‐mediated degradation or electromagnetic field‐induced deformation of matrices .…”

Section: Introductionmentioning

confidence: 99%

Active Regulation of On‐Demand Drug Delivery by Magnetically Triggerable Microspouters

Shademani

Zhang

Jackson

et al. 2016

Adv Funct Materials

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Triggerable devices capable of on‐demand, controlled release of therapeutics are attractive options for the treatment of local diseases because of their potential to enhance therapeutic effectiveness with reduced systemic toxicity. Here, the design and fabrication of a miniaturized device, termed a microspouter, is described. This device is shown to provide active and precise control of localized delivery of drugs on demand. The microspouter is composed of a magnetic sponge to provide the force for drug release through magnetic field‐induced reversible deformation, a reservoir for the sponge installation and drug loading, and a soft membrane for sealing the device. Following application of a magnetic field to the microspouter, the shrinking of the sponge may trigger a spouting of drug through a membrane's microaperture. The efficiency of the device in controlling the dose and time course of drug release under different external magnetic fields has been demonstrated using methylene blue and docetaxel as model drugs. Additionally, the microspouter is found to have low background drug leakage that allows for tunable drug release in an ex vivo implantation experiment. All the results confirm the microspouter as a potential device for safe, long‐time, and controlled drug release in local disease treatment.

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Rapid and Extensive Collapse from Electrically Responsive Macroporous Hydrogels

Cited by 42 publications

References 29 publications

Boon and Bane of Inflammation in Bone Tissue Regeneration and Its Link with Angiogenesis

Boon and Bane of Inflammation in Bone Tissue Regeneration and Its Link with Angiogenesis

Preparation and characteristics of gelatin sponges crosslinked by microbial transglutaminase

Active Regulation of On‐Demand Drug Delivery by Magnetically Triggerable Microspouters

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