Rapid and long-term plasticity in the neonatal and adult retinotectal pathways following a retinal lesion

Serfaty, Claudio Alberto; Campello-Costa, Paula; Linden, Rafael

doi:10.1016/j.brainresbull.2005.04.005

Cited by 39 publications

(33 citation statements)

References 53 publications

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“…In this time window we cannot exclude the idea that IL-6 could trigger the release of other mediators within the retina, which in turn could be responsible for the final effect on the reorganization of the retinotectal pathway. Furthermore, this data is also in agreement with previous work showing that temporal retinal lesions affect the distribution of axons from the intact eye [20]. This effect was explained by the interaction of binocular inputs on synaptic sites within the SC [46].…”

Section: Discussionsupporting

confidence: 82%

“…At PND13 or PND37 both groups (IL- or PBS-treated rats) were submitted to an intraocular injection of a 30% solution of horseradish peroxidase (HRP; type VI, Sigma Chemical Co., St. Louis, Mo., USA) in 2% DMSO in the left, nontreated eye, in order to trace the uncrossed retinotectal projection (fig. 1) as previously described [20,22]. Animals presenting lens or retinal lesions during either procedure were discarded.…”

Section: Methodsmentioning

confidence: 99%

“…As a consequence, uncrossed retinal fibers occupy the anterior third of the SC at the ventral border of visual layers while the contralateral fibers occupy the entire length of the collicular visual layers [18,19]. In rats, the critical period of these pathways extend until the third postnatal week [20]. Previously, our group demonstrated that different mechanisms are involved in the retinotectal development and plasticity [21,22,23,24].…”

Section: Introductionmentioning

confidence: 99%

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Intravitreous Injection of Interleukin-6 Leads to a Sprouting in the Retinotectal Pathway at Different Stages of Development

Menezes

Goulart

Espírito-Santo³

et al. 2016

Neuroimmunomodulation

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Objective: The development of retinotectal pathways form precise topographical maps is usually completed by the third postnatal week. Cytokines participate in the development and plasticity of the nervous system. We have previously shown that in vivo treatment with interleukin 2 disrupts the retinocollicular topographical order in early stages of development. Therefore, we decided to study the effect of a single intravitreous injection of IL-6 upon retinotectal circuitry in neonates and juvenile rats. Materials and Methods: Lister Hooded rats received an intravitreous injection of IL-6 (50 ng/ml) or vehicle (PBS) at either postnatal day (PND)10 or PND30 and the ipsilateral retinotectal pathway was evaluated 4 or 8 days later, respectively. Results: Our data showed that, at different stages of development, a single IL-6 intravitreous treatment did not produce an inflammatory response and increased retinal axon innervation throughout the visual layers of the superior colliculus. Conclusions: Taken together, our data provide the first evidence that a single intravitreous injection with IL-6 leads to sprouting in the subcortical visual connections and suggest that small changes in IL-6 levels might be sufficient to impair the correct neuronal circuitry fine-tuning during brain development.

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Section: Discussionsupporting

confidence: 82%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Intravitreous Injection of Interleukin-6 Leads to a Sprouting in the Retinotectal Pathway at Different Stages of Development

Menezes

Goulart

Espírito-Santo³

et al. 2016

Neuroimmunomodulation

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“…Sprouting of connections commonly occurs in the CNS of both developing and adult animals when target sites become available, through loss of normal input (Carmichael 2003; Salin et al 1995;Serfaty et al 2005;Steward 1992;Stroemer et al 1995;Uryu et al 2001;van Praag et al 1996;Villablanca and Hovda 2000). The missing neurons from the malformed region would have normally sent some axonal collaterals horizontally to the adjacent cortex (Burkhalter 1989;Jones 1984).…”

Section: Discussionmentioning

confidence: 99%

Postsynaptic Currents Prior to Onset of Epileptiform Activity in Rat Microgyria

Zsombok

Jacobs²

2007

Journal of Neurophysiology

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Zsombok A, Jacobs KM. Postsynaptic currents prior to onset of epileptiform activity in rat microgyria. J Neurophysiol 98: 178 -186, 2007. First published May 2, 2007 doi:10.1152/jn.00106.2007. Structural malformations of the cortex, arising as a result of genetic mutation or injury during development are associated with dyslexia, epilepsy, and other neurological deficits. We have used a rat model of a microgyral malformation to examine mechanisms of epileptogenesis. Our previous studies showed that the frequency of miniature excitatory postsynaptic currents (mEPSCs) recorded in neocortical layer V pyramidal neurons is increased in malformed cortex at a time when field potential epileptiform events can be evoked. Here we show that the increase occurs at an age before onset of cortical epileptiform activity and at a time when the frequency of mEPSCs in control layer V pyramidal neurons is stable. An increase in the frequency of spontaneous (s)EPSCs in layer V pyramidal neurons of malformed cortex occurs earlier than that for mEPSCs, suggesting that there may additionally be alterations in intrinsic properties that increase the excitability of the cortical afferents. Frequencies of EPSC bursts and late evoked activity were also increased in malformed cortex. These results suggest that a hyperinnervation of layer V pyramidal neurons by excitatory afferents occurs as an active process likely contributing to subsequent development of field epileptiform events.

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“…For example, removal of SC input in neonatal rodents results in an aberrant ipsilateral retinotectal projection [20][21][22][23][24], whereas retinal deafferentation in adults has no such effect [25][26][27]. Gradual, continuous plastic changes have been described in the ipsilateral retinal axons of adult rats subjected to contralateral retinal lesions at P21, in contrast to the fast plastic response observed in neonatal rats evident within 48 hours of lesion [28].…”

Section: Differential Lesion Responses Of Neonatal and Adult Visual Cmentioning

confidence: 99%

The Experimental Manipulation of Visual Cortex Efferents

Gerrikagoitia¹,

Rienda²,

Martínez‐Millán³

2012

Visual Cortex - Current Status and Perspectives

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Rapid and long-term plasticity in the neonatal and adult retinotectal pathways following a retinal lesion

Cited by 39 publications

References 53 publications

Intravitreous Injection of Interleukin-6 Leads to a Sprouting in the Retinotectal Pathway at Different Stages of Development

Intravitreous Injection of Interleukin-6 Leads to a Sprouting in the Retinotectal Pathway at Different Stages of Development

Postsynaptic Currents Prior to Onset of Epileptiform Activity in Rat Microgyria

The Experimental Manipulation of Visual Cortex Efferents

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