Rapid and on-site detection of multiple fentanyl compounds by dual-ion trap miniature mass spectrometry system

Kang, Manqing; Lian, Ru; Zhang, Xiaoyang; Li, Yuyu; Zhang, Yunfeng; Zhang, Yurong; Zhang, Wenpeng; Ouyang, Zheng

doi:10.1016/j.talanta.2020.121057

Cited by 31 publications

(24 citation statements)

References 44 publications

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“…The latest miniature Mini MS systems, such as the Mini 12 [ 79 ] and the dual-LIT MS [ 80 ], present a huge opportunity for POC applications [ 85 , 86 ]. Unlike unknown profiling using lab-scale instruments, the POC miniature MS systems aim on targeted analysis, such as analyzing biomarkers directly from biological samples, and the whole analysis procedures are technically accessible to nurse and physician in office or the patients themselves.…”

Section: Ms Miniaturization: a Necessary Step To On-site Applicationsmentioning

confidence: 99%

Recent advances in on-site mass spectrometry analysis for clinical applications

Zhou¹,

Zhang²,

Ouyang³

2022

TrAC Trends in Analytical Chemistry

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In recent years, mass spectrometry (MS) is increasingly attracting interests for clinical applications, which also calls for technical innovations to make a transfer of MS from conventional analytical laboratories to clinics. The system design and analysis procedure should be friendly for novice users and appliable for on-site clinical diagnosis. In addition, the analysis result should be auto-interpreted and reported in formats much simpler than mass spectra. This motivates new ideas for developments in all the aspects of MS. In this review, we report recent advances of direct sampling ionization and miniature MS system, which have been developed targeting clinical and even point-of-care analysis. We also discuss the trend of the development and provide perspective on the technical challenges raised by diseases such as coronavirus SARS-CoV-2.

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Section: Ms Miniaturization: a Necessary Step To On-site Applicationsmentioning

confidence: 99%

Recent advances in on-site mass spectrometry analysis for clinical applications

Zhou¹,

Zhang²,

Ouyang³

2022

TrAC Trends in Analytical Chemistry

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“…A commercially available portable linear ion trap MS system has been developed by PurSpec Technologies, which weighs 20 kg and can be operated with a 100 W battery [ 154 ]. It was applied with SFME nanoESI for the detection of multiple fentanyl compounds, directly from beer, milk, or cola, with an LOD of 10 ppb, featuring low chemical noise [ 155 ].…”

Section: Portable Mass Spectrometry For Food Analysismentioning

confidence: 99%

ASSURED Point-of-Need Food Safety Screening: A Critical Assessment of Portable Food Analyzers

Jafari

Guercetti

Geballa-Koukoula

et al. 2021

Foods

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Standard methods for chemical food safety testing in official laboratories rely largely on liquid or gas chromatography coupled with mass spectrometry. Although these methods are considered the gold standard for quantitative confirmatory analysis, they require sampling, transferring the samples to a central laboratory to be tested by highly trained personnel, and the use of expensive equipment. Therefore, there is an increasing demand for portable and handheld devices to provide rapid, efficient, and on-site screening of food contaminants. Recent technological advancements in the field include smartphone-based, microfluidic chip-based, and paper-based devices integrated with electrochemical and optical biosensing platforms. Furthermore, the potential application of portable mass spectrometers in food testing might bring the confirmatory analysis from the laboratory to the field in the future. Although such systems open new promising possibilities for portable food testing, few of these devices are commercially available. To understand why barriers remain, portable food analyzers reported in the literature over the last ten years were reviewed. To this end, the analytical performance of these devices and the extent they match the World Health Organization benchmark for diagnostic tests, i.e., the Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free, and Deliverable to end-users (ASSURED) criteria, was evaluated critically. A five-star scoring system was used to assess their potential to be implemented as food safety testing systems. The main findings highlight the need for concentrated efforts towards combining the best features of different technologies, to bridge technological gaps and meet commercialization requirements.

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“…A number of ambient ionization mass spectrometry (AI-MS) techniques have been demonstrated for opioid analysis, including direct analysis in real time (DART-MS) [6], direct sample analysis (DSA-MS) [7], and paper spray mass spectrometry [8]. Portable mass spectrometers, using a range of ionization techniques, have also been shown [9][10][11]. Using similar principles, ion mobility spectrometry has been reported to separate and identify some fentanyl compounds [12,13].…”

Section: Introductionmentioning

confidence: 99%

Development and evaluation of a synthetic opioid targeted gas chromatography mass spectrometry (GC‐MS) method

Sisco

Burns

Moorthy

2021

Journal of Forensic Sciences

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As seized drug casework becomes increasingly complex due to the continued prevalence of emerging drugs, laboratories are often looking for new analytical approaches including developing methods for the analysis of specific compounds classes. Recent efforts have focused on the development of targeted gas chromatography mass spectrometry (GC-MS) confirmation methods to compliment the information-rich screening results produced by techniques like direct analysis in real time mass spectrometry (DART-MS). In this work, a method for the confirmation of synthetic opioids and related compounds was developed and evaluated. An 11-component test solution was used to develop a method that focused on minimizing overlapping retention time acceptance windows and understanding the influence of instrument parameters on reproducibility and sensitivity. Investigated settings included column type, flow rate, temperature program, inlet temperature, source temperature, and tune type. Using a DB-200 column, a 35-min temperature ramped method was created. It was evaluated against a suite of 222 synthetic opioids and related compounds, and successfully differentiated all but four compound pairs based on nonoverlapping retention time acceptance windows or objectively different mass spectra. Compared to a general confirmatory method used in casework, the targeted method was up to 25 times more sensitive and provided at least a two-fold increase in retention time differences.Analysis of extracts from actual case samples successfully demonstrated utility of the method and showed no instance of carryover, although the high polarity column required wider retention time windows than other columns.

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Rapid and on-site detection of multiple fentanyl compounds by dual-ion trap miniature mass spectrometry system

Cited by 31 publications

References 44 publications

Recent advances in on-site mass spectrometry analysis for clinical applications

Recent advances in on-site mass spectrometry analysis for clinical applications

ASSURED Point-of-Need Food Safety Screening: A Critical Assessment of Portable Food Analyzers

Development and evaluation of a synthetic opioid targeted gas chromatography mass spectrometry (GC‐MS) method

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