Rapid and sensitive determination of folic acid by facile synthesized dsDNA-CuNCs fluorescent probe

Liu, Luyao; Luo, Yuchen; Zhang, Xuebing; Deng, Bo; Zhen, Deshuai; Zhou, Zhangye; Xie, Hongbin; Liang, Hao; Chen, Lili

doi:10.1039/d3nj02363j

New J. Chem.

2023

DOI: 10.1039/d3nj02363j

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Rapid and sensitive determination of folic acid by facile synthesized dsDNA-CuNCs fluorescent probe

Luyao Liu,

Yuchen Luo,

Xuebing Zhang

et al.

Abstract: Folic acid (FA) is one of the essential vitamins for the growth and reproduction of human cells, and it is of great significance to detect FA in real time.

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2024

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Cited by 3 publications

References 31 publications

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In situ synthesis of luminescent dsDNA-Cu NCs stained with a dsDNA-lighted fluorophore for rapid and stable detection of histamine in food

Chen,

Shi,

et al. 2024

International Journal of Biological Macromolecules

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In situ synthesis of luminescent dsDNA-Cu NCs stained with a dsDNA-lighted fluorophore for rapid and stable detection of histamine in food

Chen,

Shi,

et al. 2024

International Journal of Biological Macromolecules

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Thiolated RAFT-PISA nano-templates power on luminescent copper nanoclusters (CuNCs) for selective mercury (II) detection

García,

Quijada-Garrido

2024

Reactive and Functional Polymers

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Synthesis of BSA-stabilized copper nanoclusters and evaluation of their potential use as fluorescent sensors for folic acid

Munar,

Lacquio,

Remillon

et al. 2024

KIMIKA

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This study describes the synthesis and characterization of BSA-stabilized copper nanoclusters (BSA-CuNCs) for use as sensors for the B vitamin folic acid. Ascorbate served as a reducing agent while bovine serum albumin (BSA) served as a capping and stabilizing agent. The BSA-CuNCs had a golden-yellow appearance and perceivably have good dispersibility. Transmission electron microscopy indicated average diameters of the BSA-CuNCs as 2.47 ± 0.50 nm. With atomic force microscopy and dynamic light scattering, the diameters of the BSA-CuNCs were varied and larger than anticipated (64 ± 13 nm AFM; 11-608 nm DLS), since nanocluster sizes should be less than 2 nm. The BSA-CuNCs' UV–visible spectra did not show peaks in the 500–600 nm indicating the absence of the surface plasmon resonance (SPR) of larger nanoparticles. The BSA-CuNCs were excited at 320 nm and showed a fluorescence emission at 644 nm. The BSA-CuNCs were then evaluated as potential folic acid sensors. Fluorescence quenching was observed as folic acid was added incrementally. The quenching fitted well with the Stern-Volmer equation, with estimated limits for detection (LOD) and quantitation (LOQ) at 0.77 µg/mL and 2.35 µg/mL, respectively. Next, the folic acid content of some over-the-counter supplements was assessed. There was a range of 33.31% to 40.21% in the percent error between the claimed and experimental folic acid values, which were beyond the acceptable accuracy and precision errors of 5% and 10%, respectively. Nevertheless, current results may suggest potential that the BSA-CuNCs may be used to quantify folic acid. However, further research is required to improve sample preparations and analytical procedures.

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Rapid and sensitive determination of folic acid by facile synthesized dsDNA-CuNCs fluorescent probe

Abstract: Folic acid (FA) is one of the essential vitamins for the growth and reproduction of human cells, and it is of great significance to detect FA in real time.

Cited by 3 publications

References 31 publications

In situ synthesis of luminescent dsDNA-Cu NCs stained with a dsDNA-lighted fluorophore for rapid and stable detection of histamine in food

In situ synthesis of luminescent dsDNA-Cu NCs stained with a dsDNA-lighted fluorophore for rapid and stable detection of histamine in food

Thiolated RAFT-PISA nano-templates power on luminescent copper nanoclusters (CuNCs) for selective mercury (II) detection

Synthesis of BSA-stabilized copper nanoclusters and evaluation of their potential use as fluorescent sensors for folic acid

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