Rapid and simple analysis of amphetamine-type illegal drugs using excitation–emission matrix fluorescence coupled with parallel factor analysis

Abstract

Nowadays, the abuse of illegal drugs has been an increasingly grim problem in the world. Excitation–emission matrix fluorescence combined with parallel factor analysis was used to make a quantitative analysis of the simulated amphetamine-type illegal drugs. Satisfactory results were achieved for simultaneous determination of methamphetamine (MAM) and 3, 4-methylenedioxymethamphetamine (MDMA) in the presence of adulterants. The average recoveries were (99.8 ± 0.6)% and (101.6 ± 5.7)% for MAM and MDMA, respectively. Figures of merit including root-mean-square error of calibration and prediction, sensitivity and selectivity were investigated to evaluate the performance of the proposed method. The limits of detection were 0.054 and 0.002 1 μg/mL for MAM and MDMA, respectively.

Antibiotics Attenuate Methamphetamine-Induced Hepatotoxicity by Regulating Oxidative Stress and TLR4/MyD88/Traf6 Axis

“…Abuse of METH has become a major worldwide health problem ( Xu et al, 2019 ; Xu and Liu, 2019 ). As known, METH is harmful to multiple organs (e.g., the brain, heart, liver, lung, kidney, and spleen), and the current research mainly focuses on its neurotoxicity ( Liu et al, 2017 ; Moratalla et al, 2017 ; Zhang et al, 2017 ; Yang et al, 2018 ), and METH-induced hepatic injury has recently been studied ( Dias Da Silva et al, 2013 ; Halpin et al, 2013 ).…”

Interpol Review of Drug Analysis 2019-2022

“…2019 GC/MS method for fenethylline profiling of seized samples ; LC-QTOF-MS method for the simultaneous analysis of 111 amine-based compounds belonging to ergogenics, anorectics and other active components including phenethylamines (amphetamines, ephedrines), sibutramine or yohimbine [ 475 ]; excitation-emission matrix fluorescence combined with parallel factor analysis for quantitative analysis of the ATSs illegal drugs [ 476 ]; 2020 investigation of the efficiency and effectiveness of a gas-to-liquid (GTL) extraction system for the extraction of amphetamine-type substances and their precursors from the vapor phase [ 477 ]; LC-MS/MS method for detection of the presence of synthetic amines in dietary supplements [ 478 ]; enantioselective HPLC-MS/MS method for the quantification of (R)-AMP, (S)-AMP, (R)-MA, (S)-MA, (1R,2R)-pseudoephedrine, (1S,2S)-pseudoephedrine, (1R,2S)-ephedrine, (1S,2R)-ephedrine, (1R,2S)-norephedrine, (1S,2R)-norephedrine, (R)-cathinone, (S)-cathinone, and (1S,2S)-norpseudoephedrine (cathine) [ 479 ]; 2021 review of MA and AMP detection and roadside testing [ 480 ]; determination of the variations in delta C-13 and delta N-15 values of nitrogen sources used in the clandestine production of ATSs using isotope ratio mass spectrometry [ 481 ]; electrochemiluminescence strategy for the screening of MA and AMP [ 482 ]; review of laboratory-based and portable methods for detection of ATSs [ 483 ]; review of the prevalence of ATSs in Iran [ 484 ]; SALDI-MS method for the analysis of ATSs, including MA, MDMA, MDEA, and 4-fluoromethamphetamine (4-FMA) [ 485 ]; ATS drug classification using a one-dimensional convolutional neural network model [ 486 ]; 2022 colorimetric assay for detection of ATSs in aqueous solution, spiked drinks, and ‘ecstasy’ tablets [ 487 ]; development and validation of a GC-MS method for identification and quantification of AMP, MA, MDA and MDMA [ 488 ]; development of drug screening kits for the detection of ATSs in drinks [ 489 ]; analysis of feature selection method for 3D molecular structure of ATS drugs [ 490 ]; study of the pharmacological properties of MDA analogues and two related amphetamine-based compounds (N,alpha-DEPEA and DPIA) detected in street drug samples or in sport supplements [ 491 ]; chiral analysis of AMP (n = 143), MDMA (n = 94), and MA (n = 528) in samples seized in southern Germany in 2019 and 2020 using different chromatographic methods [ 492 ]; comparison of different chiral selectors for the enantiomeric determination of amphetamine-type substances by SPE-CE-MS/MS [ 493 ]; ultrahigh performance LC-MS/MS (UPLC-MS/MS) method coupled with magnetic SPE (MSPE) for determination of ultra-trace ATSs [ 494 ]; desk review of Vietnamese national drug policy documents regarding ATSs and in-depth key informant interviews were conducted from 2019 to 2021 [ 495 …”

Identification Using Classification Analysis of Flunitrazepam in Necrophagous Larvae via Differential Pulse Voltammetry and Fluorescence Excitation-Emission Matrix (EEM) Spectroscopy

“…25 It has also been used the EEM fluorescence combined with parallel factorial analysis (PARAFAC) to develop a quantitative method for analyzing simulated amphetamine-type illegal drugs. 26 Satisfactory results were found for the simultaneous determination of methamphetamine and 3,4-ethylenedioxymethamphetamine in the presence of the drug.…”