Rapid and simultaneous determination of ultrashort-, short- and long- chain perfluoroalkyl substances by a novel liquid chromatography mass spectrometry method

Zou, Jianmin; Zhao, Mengzhe; Chan, Shen-An; Song, Yue; Yan, Shuwen; Song, Weihua

doi:10.1016/j.chroma.2024.465324

Journal of Chromatography A

2024

DOI: 10.1016/j.chroma.2024.465324

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Rapid and simultaneous determination of ultrashort-, short- and long- chain perfluoroalkyl substances by a novel liquid chromatography mass spectrometry method

Jianmin Zou,

Mengzhe Zhao,

Shen-An Chan

et al.

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Simultaneous and Rapid Analysis of Multiclass Emerging Contaminants Using a Column-Switching LC-MS Method

Zhao,

Yan,

Zhang

et al. 2024

Environ. Sci. Technol. Lett.

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Contaminants of emerging concern (CECs) in aquatic environments have attracted a considerable amount of attention from the public and regulatory groups. Due to their wide variety of chemical properties, simultaneous analysis of multiclass CECs presents a great challenge. This study develops an innovative liquid chromatography-mass spectrometry (LC-MS) method that integrates both large volume injection (LVI) and online solid phase extraction to quantify 102 CECs. The method utilizes three columns: a reversed phase (RP) column, a custom-built mixed weak cation/anion exchange trap column, and a mixed-mode ion exchange (MMIE) column. With valve switching, highly polar/ ionic CECs that are not retained by the RP column are captured by the trap column while other CECs are separated by the RP column. Subsequently, the trapped highly polar/ionic CECs are transferred to the MMIE column for further separation. Matrix effects from sewage effluent and urine samples were assessed, and the method accuracy and precision were also determined using spike recovery. LVI notably enhanced the method sensitivity, with the method quantification limits for 93 of the 102 CECs in various water matrices being <10 ng L −1 . Overall, this novel columnswitching LC-MS method enables the rapid and simultaneous determination of multiclass CECs in diverse aqueous samples.

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Simultaneous and Rapid Analysis of Multiclass Emerging Contaminants Using a Column-Switching LC-MS Method

Zhao,

Yan,

Zhang

et al. 2024

Environ. Sci. Technol. Lett.

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show abstract

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Rapid and simultaneous determination of ultrashort-, short- and long- chain perfluoroalkyl substances by a novel liquid chromatography mass spectrometry method

Cited by 1 publication

References 30 publications

Simultaneous and Rapid Analysis of Multiclass Emerging Contaminants Using a Column-Switching LC-MS Method

Simultaneous and Rapid Analysis of Multiclass Emerging Contaminants Using a Column-Switching LC-MS Method

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