Rapid and sustained allogeneic transplantation using immunoselected CD34(+)-selected peripheral blood progenitor cells mobilized by recombinant granulocyte- and granulocyte-macrophage colony-stimulating factors [letter]

Corringham, Robert; Ho, A. D.

doi:10.1182/blood.v86.5.2052a.bloodjournal8652052a

Cited by 40 publications

(9 citation statements)

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“…In poor mobilisers, the combination of G‐CSF plus GM‐CSF, which was already investigated by Corringham and Ho (1995), appeared to be as effective as high‐dose G‐CSF for PBSC mobilization, at a lower cost (Bashey et al, 2000; Stiff et al, 2002).…”

Section: New Strategies To Optimize Pbsc Mobilizationmentioning

confidence: 99%

It's moving day: factors affecting peripheral blood stem mobilization and strategies for improvement

Früehauf

Seggewiss

2003

Br J Haematol

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Section: New Strategies To Optimize Pbsc Mobilizationmentioning

confidence: 99%

It's moving day: factors affecting peripheral blood stem mobilization and strategies for improvement

Früehauf

Seggewiss

2003

Br J Haematol

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“…The optimum number of CD34 cells required for rapid haemopoietic engraftment is not yet clear. In the autologous setting many groups have reported a threshold CD34 count of > 2 : 5 2 10 6 /kg to be associated with rapid engraftment (Hass et al, 1994;Bender et al, 1992;Haynes et al, 1995) and most investigators have regarded a figure of 2-3 2 10 6 /kg CD34 cells to be a minimum target for allogeneic transplantation, although the Seattle group have set a higher target CD34 cell dose of 15 2 objective of reducing the number of leukapheresis procedures required (Corringham & Ho, 1995). In the EBMT series of 59 donors undergoing mobilization with G-CSF the median number of CD34 cells collected was 6 : 7 2 10 6 /kg ; however, some patients have received < 2 2 10 6 CD34 cells/kg without any adverse effects on engraftment.…”

Section: Mobilization Of Blood Stem Cells In Normal Donorsmentioning

confidence: 99%

The Place of Blood Stem Cells in Allogeneic Transplantation

1996

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“…As leukapheresis procedures are expensive and are associated with some donor inconvenience and risk, we and others have endeavored to define mobilization regimens that will reliably facilitate the collection of an adequate dose of PBPCs with a minimum number of procedures. Finally, because idiosyncratic or allergic reactions to individual cytokines may preclude their use, and because our experience showed that not all persons can undergo effective mobilization with a single cytokine, there is a need to develop additional regimens to mobilize PBPCs with acceptable donor tolerance, using combinations of readily available cytokines 18–20 …”

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confidence: 99%

Mobilization of blood‐derived stem and progenitor cells in normal subjects by granulocyte‐macrophage‐ and granulocyte‐colony‐stimulating factors

Lane

Bashey

et al. 1999

Transfusion

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BACKGROUND: It was previously reported that the combination of granulocyte‐macrophage‐colony‐stimulating factor (GM–CSF) and granulocyte‐CSF (G–CSF) for 4 days mobilized more primitive CD34+ subsets than did either G–CSF or GM–CSF alone. STUDY DESIGN AND METHODS: The studies determine the optimal number of days of growth factor dosing for mobilization and collection of peripheral blood progenitor cells, by increasing the days of administration of GM–CSF and/or G–CSF or employing the sequential administration of GM–CSF followed by G–CSF. Sixty normal subjects were given injections of G–CSF or GM–CSF alone; GM–CSF and G–CSF concurrently for 4, 5, or 6 days; or a sequential regimen of GM–CSF for 3 or 4 days followed by G–CSF for 2 or 3 days. A 10‐L apheresis was performed 24 hours after the last dose. RESULTS: The three most efficacious mobilization regimens consisted of sequential GM–CSF for 3 days followed by G–CSF for either 2 or 3 days and G–CSF alone for 5 days. Each of these regimens resulted in the collection of significantly greater numbers of CD34+ cells by apheresis than any of the 4‐day dosing regimens with G–CSF and/or GM–CSF (sequential GM–CSF/G–CSF: 3 days/2 days = 3.58 ± 0.53 × 106 CD34+ cells/kg; GM–CSF/G–CSF: 3 days/3 days = 4.45 ± 1.08 × 106 CD34+ cells/kg; G–CSF: 5 days = 3.58 ± 0.97 × 106 CD34+ cells/kg; all p < 0.05 vs. G–CSF and/or GM–CSF for 4 days). Clonogenic assays generally paralleled the level of CD34+ cells. Regimens containing GM–CSF resulted in a higher percentage of the cells from primitive CD34+/CD38–/HLA‐DR+ subset than G–CSF alone. CONCLUSION: Compared with 4‐day dosing regimens with G–CSF and/or GM–CSF, mobilization of CD34+ cells in normal subjects using sequential GM–CSF for 3 days followed by G–CSF for 2 or 3 days or using G–CSF alone for 5 days increased the number CD34+ cells that can be collected by a single 10‐L apheresis 24 hours after the last dose of cytokine.

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Rapid and sustained allogeneic transplantation using immunoselected CD34(+)-selected peripheral blood progenitor cells mobilized by recombinant granulocyte- and granulocyte-macrophage colony-stimulating factors [letter]

Cited by 40 publications

References 0 publications

It's moving day: factors affecting peripheral blood stem mobilization and strategies for improvement

It's moving day: factors affecting peripheral blood stem mobilization and strategies for improvement

The Place of Blood Stem Cells in Allogeneic Transplantation

Mobilization of blood‐derived stem and progenitor cells in normal subjects by granulocyte‐macrophage‐ and granulocyte‐colony‐stimulating factors

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