Rapid blood cell recovery with immunosuppressive therapy combined with romiplostim in a patient with very severe hepatitis-associated aplastic anemia who underwent liver transplantation

Yoshinari, H.; Kawahara, Yuta; Niijima, Hitomi; Oh, Yukiko; Hirata, Yuta; Okada, Noriki; Sanada, Yukihiro; Onishi, Yuki; Sakuma, Yoshiki; Morimoto, Akira

doi:10.1007/s12185-021-03165-z

Cited by 3 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, FH did not recur after LDLT even though the donor's liver shared the HLA haplotype that was lost in the recipient liver as a result of 6pLOH. Previous studies that reported successful treatment of HAAA after LDLT with IST did not observe a recurrence of FH in the donor's liver either 5,9,10,12–14 . Although the reason for the non‐recurrence of FH in our patient is unclear, the target antigen of pathogenic CD8 + T cells may be a polymorphic protein unique to the recipient.…”

Section: Discussionmentioning

confidence: 47%

See 1 more Smart Citation

A case of hepatitis‐associated aplastic anaemia following living‐donor liver transplantation for fulminant hepatitis showing loss of heterozygosity in the 6p chromosome in the affected liver

Katagiri,

Iwasaki,

Fujieda

et al. 2023

Br J Haematol

View full text Add to dashboard Cite

SummaryThe mechanisms underlying hepatitis‐associated aplastic anaemia (HAAA) that occurs several weeks after the development of acute hepatitis are unknown. A 20‐year‐old male developed HAAA following living‐donor liver transplantation for fulminant hepatitis. The patient's leucocytes lacked HLA‐class I due to loss of heterozygosity in the short arm of chromosome 6p (6pLOH). Interestingly, the patient's liver cells resected during the transplantation also exhibited 6pLOH that affected the same HLA haplotype as the leucocytes, suggesting that CD8+ T cells recognizing antigens presented by specific HLA molecules on liver cells may have attacked the haematopoietic stem cells of the patient, leading to the HAAA development.

show abstract

Section: Discussionmentioning

confidence: 47%

“…Previous studies that reported successful treatment of HAAA after LDLT with IST did not observe a recurrence of FH in the donor's liver either. 5,9,10,[12][13][14] Although the reason for the non-recurrence of FH in our patient is unclear, the target antigen of pathogenic CD8 + T cells may be a polymorphic protein unique to the recipient.…”

Section: Discussionmentioning

confidence: 85%