Rapid Cardiotonic Effects of Lipid Emulsion Infusion*

Fettiplace, Michael R.; Ripper, Richard; Lis, Kinga; Lin, Bocheng; Lang, Jason; Zider, Brian; Wang, Jing; Rubinstein, Israel; Weinberg, Guy

doi:10.1097/ccm.0b013e318287f874

Cited by 119 publications

(114 citation statements)

References 52 publications

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“…Experimentally, rats infused with lipid emulsion showed an increased blood pressure and aortic flow rates relative to the same volume of saline. Additionally, isolated rat hearts in isovolumetric contraction were seen to contract more forcefully, with increased oxygen demand, when perfusate was augmented with lipid emulsion [11]. Stehr and colleagues [12] additionally demonstrated a positive effect on bupivacaine toxic cardiac myocytes at levels below those that could have effected any "sink" phenomenon.…”

Section: Cardiotonic Effectmentioning

confidence: 98%

Lipid Emulsion Infusion in Resuscitation for Local Anesthetic and Other Drug Overdose

Chaparoska¹,

Baneva²

2014

Macedonian Medical Review

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The use of intravenous lipid emulsions (ILEs) as antidote in local anesthetic systemic toxicity has gained widespread support following convincing data from animal models, and successful case reports in humans. Аn injection of a simple, intravenous nutritional solution could be acutely life-saving for a patient with severe drug overdose. But dozens of published case reports support this observation, the first ones made more than a decade ago in a rodent model of bupivacaine toxicity. It is even more surprising that such a simple formulation can rapidly reverse severe clinical toxicity from a variety of vastly disparate medications with distinct pharmacodynamics and mechanisms of action. This review will focus on the clinical application of lipid emulsion therapy in resuscitation from drug-related toxicity and will provide an introduction to the development of a method, guidelines for its use, and insights into potential controversies and future applications [1].

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Section: Cardiotonic Effectmentioning

confidence: 98%

Lipid Emulsion Infusion in Resuscitation for Local Anesthetic and Other Drug Overdose

Chaparoska¹,

Baneva²

2014

Macedonian Medical Review

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“…Causing the inhibition of mitochondrial metabolism of lipids, ILE decreases tissue acidosis in myocardial ischemia and also decreases CO2 production [14]. It was also observed that ILE improved myocyte functions by increasing intracellular calcium level [16].…”

Section: Introductionmentioning

confidence: 96%

“…Providing energy resource to myocardium with a high dose of free fatty acid as another effect mechanism, it is considered that long chain fatty acids activate voltage -gated calcium channels in cardiac myocytes [13,14]. On the other hand, researches on ILE treatment continue anyway.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Intravenous Lipid Emulsion Treatment in the Preventi̇on of Depressive Effects of Propofol on Cardiovascular and Respiratory System: An Experimental Animal Study

Doğanay¹,

Ak²,

Alışkan³

et al. 2018

Preprint

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Propofol is the general anesthetic used for the anesthesia induction and its continuation. Propofol is generally safe and it doesn't have an antidote. Propofol has severe side effects such as cardiovascular depression and hypotension. The aim of this study was observed the effects of intravenous lipid emulsion (ILE) treatment in the preventı̇on of depressive effects of propofol on cardiovascular and respiratory system. Twenty-eight Sprague-Dawley adult rats randomly divided into 4 groups. The saline administered group was defined as the control group. The second group administered propofol, the third group administered ILE, and the fourth administered propofol with ILE therapy. Systolic blood pressure (SBP), Diastolic blood pressure (DBP), Median arterial blood pressure (MAP), Respiratory rate (RR), Heart rate (HR) and mortality were recorded during 60 minutes of follow-up. In the propofol group, SBP, DBP, MAP, RR and HR scores were decline steadily, after 60 minutes all rats in this group died. In the ILE group with propofol, after a while, decreased SBP, DBP, MAP, RR and HR scores was increased, and these values were observed close to the control group. The mortality ratio of the propofol group was detected as 100%, and survival ratio was found 100% in ILE + propofol group. The side effects such as hypotension, bradycardia and respiratory depression which can be seen after propofol application in rats could be recovered with ILE treatment and mortality due to these side effects were prevented.

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“…Several recently discovered applications and effects of lipid emulsions are described below. (17,18) by administering 20% soybean oil to male SpragueDawley rats and continuously measuring arterial pressure and aortic flow. Lipid infusion increased aortic flow and arterial pressure faster and to a greater extent than saline infusion.…”

Section: Introductionmentioning

confidence: 99%

Lipid Emulsion, More Than Reversing Bupivacaine Cardiotoxicity: Potential Organ Protection

et al. 2017

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Efforts to develop a treatment for bupivacaine cardiotoxicity led to the discovery that Intralipid, a popular brand of intravenous lipid emulsion, could be used not only as an effective treatment for anesthetic-induced cardiac arrest, but also as a means of reversing many other toxicities. Contradictory data exist regarding the mechanism of action of lipid emulsion, a combination of fatty acids traditionally used in parenteral nutrition. Some researchers attribute the effects to lipophilicity and the individual characteristics of the lipids, while other data demonstrate a direct empowering mechanism through cellular upstream and downstream pathways. Understanding the underlying mechanism of action of this safe source of calories may assist in the development of novel organ protective agents. In this review, some of the direct cardiac effects of lipid emulsion are briefly discussed. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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Rapid Cardiotonic Effects of Lipid Emulsion Infusion*

Cited by 119 publications

References 52 publications

Lipid Emulsion Infusion in Resuscitation for Local Anesthetic and Other Drug Overdose

Lipid Emulsion Infusion in Resuscitation for Local Anesthetic and Other Drug Overdose

The Effects of Intravenous Lipid Emulsion Treatment in the Preventi̇on of Depressive Effects of Propofol on Cardiovascular and Respiratory System: An Experimental Animal Study

Lipid Emulsion, More Than Reversing Bupivacaine Cardiotoxicity: Potential Organ Protection

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