Rapid carvedilol up-titration in hospitalized patients with left ventricular systolic dysfunction – data from the Carvedilol in Hospital: Up-titration Limits after Acute Patients Admission registry

Abstract

Carvedilol up-titration is well tolerated in patients hospitalized with depressed LVEF, with or without heart failure, with a high compliance rate at discharge and in the long term.

Managing Beta-blockers in Acute Heart Failure: When to Start and When to Stop?

“…On the other hand, the safety of rapid carvedilol uptitration in patients with depressed LVEF also was shown. Carvedilol uptitration was well tolerated in patients with or without HF hospitalized with depressed LVEF, with a high compliance rate at discharge and in the long term [21]. Furthermore, use of natriuretic peptides (NPs) and echocardiographic LV filling pressure indexes on top of New York Heart Association class can help estimation of β-blocker tolerance more accurately than clinical indexes alone in patients with systolic HF [22] because patients with severe HF may require early recognition of signs of exacerbation related with initiation or uptitration of β-blocker therapy.…”