Rapid cervical phIGFBP-1 test in asymptomatic twin pregnancies: role in mid-pregnancy prediction of spontaneous preterm delivery

Fichera, A.; Prefumo, Federico; Stagnati, V.; Frusca, T.

doi:10.1002/pd.4328

Cited by 15 publications

(18 citation statements)

References 47 publications

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“…Of these, 22 were excluded, mainly because they were not a test accuracy study, were duplicate publications, or did not report original data. A total of 43 studies, including 10,203 women, met the inclusion criteria, of which nine provided data on asymptomatic women (n=6131), 36-44 28 on symptomatic women (n=3212), 18,45-71 and six on both asymptomatic (n=452) and symptomatic (n=408) women. 17,72-76 …”

Section: Resultsmentioning

confidence: 99%

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Cervical phosphorylated insulin-like growth factor binding protein-1 test for the prediction of preterm birth: a systematic review and metaanalysis

Conde-Agudelo

Romero

2016

American Journal of Obstetrics and Gynecology

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OBJECTIVE To assess the accuracy of the cervical phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) test to predict preterm birth in women with and without symptoms of preterm labor through use of formal methods for systematic reviews and meta-analytic techniques. DATA SOURCES PubMed, Embase, Cinahl, Lilacs, and Medion (all from inception to June 20, 2015), reference lists, conference proceedings, and Google scholar. STUDY ELIGIBILITY CRITERIA Cohort or cross-sectional studies that reported on the predictive accuracy of cervical phIGFBP-1 test for preterm birth. STUDY APPRAISAL AND SYNTHESIS METHODS Two reviewers independently selected studies, assessed risk of bias, and extracted data. Summary receiver operating characteristic curves, pooled sensitivities and specificities, and summary likelihood ratios were generated. RESULTS Forty-three studies met the inclusion criteria of which 15 provided data on asymptomatic women (n=6583) and 34 on women with an episode of preterm labor (N=3620). Among asymptomatic women, the predictive accuracy of cervical phIGFBP-1 test for preterm birth at <37, <34 and <32 weeks of gestation was minimal with pooled sensitivities and specificities, and summary positive and negative likelihood ratios ranging from 14-47%, 76-93%, 1.5-4.4, and 0.6-1.0, respectively. Among women with an episode of preterm labor, the test had a low predictive performance for delivery within 7 and 14 days of testing, and preterm birth at <34 and <37 weeks of gestation with pooled sensitivities and specificities, and summary positive and negative likelihood ratios that varied between 60 and 68%, 77 and 81%, 2.7 and 3.5, and 0.4 and 0.5, respectively. A negative test result in women with an episode of preterm labor had a low to moderate accuracy to identify women who are not at risk for delivering within the next 48 hours (summary negative likelihood ratio of 0.28 in all women and 0.23 in women with singleton gestations). CONCLUSION Cervical phIGFBP-1 has potential utility to identify patients with an episode of preterm labor who will not deliver within 48 hours. However, its overall predictive ability for the identification of symptomatic and asymptomatic women at risk for preterm birth is limited.

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Section: Resultsmentioning

confidence: 99%

“…44 The remaining study measured the concentration of cervical phIGFBP-1 at 12-13 and 18-20 weeks of gestation. 40 Most studies in symptomatic women assessed the test between 22-24 and 34-36 weeks of gestation.…”

Section: Resultsmentioning

confidence: 99%

Cervical phosphorylated insulin-like growth factor binding protein-1 test for the prediction of preterm birth: a systematic review and metaanalysis

Conde-Agudelo

Romero

2016

American Journal of Obstetrics and Gynecology

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“…To date, there is evidence that both term and preterm labor are linked to an inflammatory process, and over the last few decades several biomarkers, including inflammatory cytokines, have been investigated for the prediction of PTB. Recently, Abbot et al .…”

Section: Discussionmentioning

confidence: 99%

Cervical length at mid-gestation in screening for preterm birth in twin pregnancy

Pagani

Stagnati

Fichera

et al. 2016

Ultrasound Obstet Gynecol

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“…93,94 Overall, the measurement of ph IGFBP-1 had minimal predictive accuracy for preterm birth at <34 weeks of gestation (pooled sensitivity, specificity, and positive and negative likelihood ratios of 16%, 93%, 2.3, and 0.9, respectively). No study has evaluated ph IGFBP-1 in women with twin gestations and threatened preterm labor.…”

Section: Biochemical Testsmentioning

confidence: 98%

Prediction of preterm birth in twin gestations using biophysical and biochemical tests

Conde-Agudelo

Romero

2014

American Journal of Obstetrics and Gynecology

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The objective of this study was to determine the performance of biophysical and biochemical tests for the prediction of preterm birth in both asymptomatic and symptomatic women with twin gestations. We identified a total of 19 tests proposed to predict preterm birth, mainly in asymptomatic women. In these women, a single measurement of cervical length with transvaginal ultrasound before 25 weeks of gestation appears to be a good test to predict preterm birth. Its clinical potential is enhanced by the evidence that vaginal progesterone administration in asymptomatic women with twin gestations and a short cervix reduces neonatal morbidity and mortality associated with spontaneous preterm delivery. Other tests proposed for the early identification of asymptomatic women at increased risk of preterm birth showed minimal to moderate predictive accuracy. None of the tests evaluated in this review meet the criteria to be considered clinically useful to predict preterm birth among patients with an episode of preterm labor. However, a negative cervicovaginal fetal fibronectin test could be useful in identifying women who are not at risk for delivering within the next week, which could avoid unnecessary hospitalization and treatment. This review underscores the need to develop accurate tests for predicting preterm birth in twin gestations. Moreover, the use of interventions in these patients based on test results should be associated with the improvement of perinatal outcomes.

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Rapid cervical phIGFBP-1 test in asymptomatic twin pregnancies: role in mid-pregnancy prediction of spontaneous preterm delivery

Cited by 15 publications

References 47 publications

Cervical phosphorylated insulin-like growth factor binding protein-1 test for the prediction of preterm birth: a systematic review and metaanalysis

Cervical phosphorylated insulin-like growth factor binding protein-1 test for the prediction of preterm birth: a systematic review and metaanalysis

Cervical length at mid-gestation in screening for preterm birth in twin pregnancy

Prediction of preterm birth in twin gestations using biophysical and biochemical tests

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