Rapid change in mouse mitochondrial DNA

Pergams, Oliver R. W.; Barnes, Wayne M.; Nyberg, Dennis

doi:10.1038/423397a

Cited by 36 publications

(27 citation statements)

References 6 publications

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“…Using cytochrome b as a marker for the accumulations of adaptations elsewhere on the genome may yield information about the effects of selection on local populations through time. Further exploration is necessary to investigate and identify the presence of locally adapted mtDNA and the rates of evolutionary change necessary to produce the variation in gene diversity we have observed (e.g., Pergams et al 2003). …”

Section: Discussionmentioning

confidence: 99%

“…We view this approach as “phylochronology,” or the study of populations in space and time using phylogenetic and population genetic methods. Similar studies have not used such a long temporal record (Pergams et al 2003), have not considered gene flow (Lambert et al 2002; Pergams et al 2003), or have used a spatially averaged sample as a proxy for a single locality (Leonard et al 2000). …”

Section: Introductionmentioning

confidence: 99%

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Genetic Response to Climatic Change: Insights from Ancient DNA and Phylochronology

et al. 2004

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Understanding how climatic change impacts biological diversity is critical to conservation. Yet despite demonstrated effects of climatic perturbation on geographic ranges and population persistence, surprisingly little is known of the genetic response of species. Even less is known over ecologically long time scales pertinent to understanding the interplay between microevolution and environmental change. Here, we present a study of population variation by directly tracking genetic change and population size in two geographically widespread mammal species (Microtus montanus and Thomomys talpoides) during late-Holocene climatic change. We use ancient DNA to compare two independent estimates of population size (ecological and genetic) and corroborate our results with gene diversity and serial coalescent simulations. Our data and analyses indicate that, with population size decreasing at times of climatic change, some species will exhibit declining gene diversity as expected from simple population genetic models, whereas others will not. While our results could be consistent with selection, independent lines of evidence implicate differences in gene flow, which depends on the life history strategy of species.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genetic Response to Climatic Change: Insights from Ancient DNA and Phylochronology

et al. 2004

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“…If replacement or partial replacement of mtDNA phylogroups is common in a continental setting, then that makes suspect phylogeographic interpretations based solely on current genetic patterns (for a review, see Hewitt 2000). Techniques that can be applied to samples of varying antiquity are particularly valuable to test for replacement in both humans (Fregel et al 2009) and wild mammals, and, for the latter, ancient DNA studies and studies using museum specimens have demonstrated replacement events unequivocally in a continental context (Barnes et al 2002;Pergams et al 2003;Hofreiter et al 2007). If, as we suggest, climate is driving the replacement events, then not only does this influence the interpretation of phylogeographic patterns created in the past, it also has implications for the persistence and genetic architecture of species during current and future global warming.…”

Section: Resultsmentioning

confidence: 99%

The Celtic fringe of Britain: insights from small mammal phylogeography

et al. 2009

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Recent genetic studies have challenged the traditional view that the ancestors of British Celtic people spread from central Europe during the Iron Age and have suggested a much earlier origin for them as part of the human recolonization of Britain at the end of the last glaciation. Here we propose that small mammals provide an analogue to help resolve this controversy. Previous studies have shown that common shrews (Sorex araneus) with particular chromosomal characteristics and water voles (Arvicola terrestris) of a specific mitochondrial (mt) DNA lineage have peripheral western/northern distributions with striking similarities to that of Celtic people. We show that mtDNA lineages of three other small mammal species (bank vole Myodes glareolus, field vole Microtus agrestis and pygmy shrew Sorex minutus) also form a 'Celtic fringe'. We argue that these small mammals most reasonably colonized Britain in a two-phase process following the last glacial maximum (LGM), with climatically driven partial replacement of the first colonists by the second colonists, leaving a peripheral geographical distribution for the first colonists. We suggest that these natural Celtic fringes provide insight into the same phenomenon in humans and support its origin in processes following the end of the LGM.

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“…PL mice in the Chicago area have exhibited rapid changes in mitochondrial DNA and concordant morphological evolution over the past 30 years (Pergams et al, 2003; Pergams & Lacy 2008). One explanation is that immigrants from genetically distinct neighboring populations invaded and replaced the regional population over a short time period, which appears to have been facilitated by large environmental changes caused by humans.…”

Section: Discussionmentioning

confidence: 99%

Cloning and molecular characterization of telomerase reverse transcriptase (TERT) and telomere length analysis of Peromyscus leucopus

Zhao

Ueda

Alaks

et al. 2015

Gene

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Telomerase reverse transcriptase (TERT) is the catalytic subunit of telomerase complex that regulates telomerase activity to maintain telomere length for all animals with linear chromosomes. As the Mus musculus (MM) laboratory mouse has very long telomeres compared to humans, a potential alternative animal model for telomere research is the Peromyscus leucopus (PL) mouse that has telomere lengths close to the human range and has the wild counterparts for comparison. We report the full TERT coding sequence (pTERT) from PL mice to use in the telomere research. Comparative analysis with eight other mammalian TERTs revealed a pTERT protein considerably homologous to other TERTs and preserved all TERT specific-sequence signatures, yet with some distinctive features. pTERT displayed the highest nucleotide and amino acid sequence homology with hamster TERT. Unlike human but similar to MM mice, pTERT expression was detected in various adult somatic tissues of PL mice, with the highest expression in testes. Four different captive stocks of PL mice and wild-captured PL mice each displayed group-specific average telomere lengths, with the longest and shortest telomeres in inbred and outbred stock mice, respectively. pTERT showed considerable numbers of synonymous and nonsynonymous mutations. A pTERT proximal promoter region cloned was homologous among PL and MM mice and rat, but with species-specific features. From PL mice, we further cloned and characterized ribosomal protein, large, P0 (pRPLP0) to use as an internal control for various assays. Peromyscus mice have been extensively used for various studies, including human diseases, for which pTERT and pRPLP0 would be useful tools.

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Rapid change in mouse mitochondrial DNA

Cited by 36 publications

References 6 publications

Genetic Response to Climatic Change: Insights from Ancient DNA and Phylochronology

Genetic Response to Climatic Change: Insights from Ancient DNA and Phylochronology

The Celtic fringe of Britain: insights from small mammal phylogeography

Cloning and molecular characterization of telomerase reverse transcriptase (TERT) and telomere length analysis of Peromyscus leucopus

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