Rapid characterization of drugs in a single hair using thermal desorption ionization mass spectrometry

Abstract

Hair remains the most common type of physical evidence found in most crime scenes. However, the amount of the hair found at a crime scene is limited and analysis of...

Applications of ambient ionization mass spectrometry in 2022: An annual review

“…40 The PDA film inside the technique for the rapid analysis of drugs in hair samples. 41 In this technique, a single hair is placed on a metal ceramic heater and a high voltage and solvent are added to the sample. This results in the thermal desorption and ionization of drugs within the hair without the need for pulverization, extraction and chromatographic analysis typically used for hair-based drug testing.…”

“…Though the detection of illicit substances in body fluids is more typical, Kong et al. presented an AIMS technique for the rapid analysis of drugs in hair samples 41 . In this technique, a single hair is placed on a metal ceramic heater and a high voltage and solvent are added to the sample.…”

Diverse thermal desorption combined with self-aspirating corona discharge ionization for direct mass spectrometry analysis of complex samples

“…[5][6][7] These treatments facilitate the identication of multiple ingredients in raw samples, but they also have some disadvantages, such as being time-consuming and high solvent consumption. [8][9][10] In recent years, the development of rapid and green analytical methods has attracted increasing attention.…”

Micro-tapered aperture nebulization ionization for versatile mass spectrometry analysis

“…In particular, the introduction of ambient ionization mass spectrometry (AIMS) 1 has opened up a new era of direct sampling MS techniques, which allows rapid and high-throughput analysis of various raw samples in the real world. [2][3][4][5][6][7] To date, a variety of ambient ionization techniques have emerged, and most of them are initiated by several elementary mechanisms, such as electrospray and discharge. [8][9][10][11] To perform these ionization methods, high voltage (HV) is typically required, which can offer high ion yields and generate positive or negative ions by switching the voltage polarity.…”