Rapid Characterization of Tanshinone Extract Powder by Near Infrared Spectroscopy

Abstract

Chemical and physical quality attributes of herbal extract powders play an important role in the research and development of Chinese medicine preparations. The active pharmaceutical ingredients have a direct impact on the herbal extract's efficacy, while the physical properties of raw material affect the pharmaceutical manufacturing process and the final products' quality. In this study, tanshinone extract powders from Salvia miltiorrhiza which are widely used for the treatment of cardiovascular diseases in the clinic are taken as the research object. Both the chemical information and physical information of tanshinone extract powders are analyzed by near infrared (NIR) spectroscopy. The partial least squares (PLS) and least square support vector machine (LS-SVM) models are investigated to build the relationship between NIR spectra and reference values. PLS models performed well for the content of crytotanshinone, tanshinone IIA, the moisture, and average median particle size, while, for specific surface area and tapped density, the LS-SVM models performed better than the PLS models. Results demonstrated NIR to be a valid and fast process analytical technology tool to simultaneously determine multiple quality attributes of herbal extract powders and indicated that there existed some nonlinear relationship between NIR spectra and physical quality attributes.

Rapid Determination of Saponins in the Honey-Fried Processing of Rhizoma Cimicifugae by Near Infrared Diffuse Reflectance Spectroscopy

“…However, the information contained in the different spectral ranges is different. Therefore, a more accurate quantitative model can be obtained by selecting an appropriate spectral interval model [ 26 ]. In this research, the spectrum of Shengmaxinside I standard product was compared with multiple ranges, and R 2 , RMSECV, RPD, and RMSEP were selected as comprehensive indicators to examine.…”

Detection and quantification of active pharmaceutical ingredients as adulterants in Garcinia cambogia slimming preparations using NIR spectroscopy combined with chemometrics

“…NIR spectroscopy with chemometrics, proved to be an analytical tool of astonishing power in the world of pharmaceutical industry, and is in a non-stop growth as an striking complementary method for analysis of herbal drugs (Luo et al, 2015). When compared to other platforms of analysis, NIR spectroscopy reveals to have noticeable features especially its nondestructive nature of the analyzed sample and its capability of obtaining spectra for samples of different physical natures without or with only diminished pretreatment of such analyzed samples (Wang and Yu, 2015).…”