Rapid Clinical and Radiologic Responses With Larotrectinib Treatment in a Patient With TRK-Fusion–Positive Metastatic Lung Cancer

Acid-Promoted [3 + 1 + 1] Cyclization of N-Tosylhydrazones and Isocyanides: A Method for the Preparation of 4,5-Diaminopyrazoles

“…4,5-Diaminopyrazoles, as functional motifs, are frequently applied in the preparation of fused heterocyclic compounds, such as pyrazolo­[3,4- b ]­pyrazines, 1,2,4-triazoles, imidazo­[4,5- c ]­pyrazoles, and benzodiazepines, which have been evaluated for a wide range of pharmaceutical and biological activities . For example, larotrectinib has been recently approved by the U.S. Food and Drug Administration for the treatment of adult and pediatric patients with solid tumors that have a neurotrophic receptor tyrosine kinase (NTRK) gene fusion due to its striking efficacy toward 17 different kinds of tumors, and some imidazo­[4,5- c ]­pyrazole derivatives show promise as anti-Alzheimer’s drugs (Figure ). Additionally, this class of compounds has found wide application in the hair dye industry…”