Until COVID-19, the greatest national public health crisis was the 1918 influenza pandemic, which was covered extensively by Public Health Reports. [1][2][3][4][5][6] Extrapolating from their knowledge of tuberculosis, public health authorities at that time exhorted ill people to remain home to break the chain of respiratory transmission. 7 Other contemporaneous appeals that reverberate a century later include "avoid needless crowding," "stay in the open air," "wear a gauze mask over the nose and mouth," and "keep away from houses where there are influenza cases." 2 In 2020, COVID-19 spurred case investigation and contact tracing at levels never seen in the United States. [8][9][10][11][12] Until vaccines, therapeutics, and SARS-CoV-2 tests became available, mitigation measures were strictly nonpharmaceutical. These included physical distancing, wearing face masks, and enhancing ventilation. In this context, state, tribal, local, and territorial health departments relied on asking people with COVID-19 to isolate and share information about close contacts (ie, case investigation) so that exposed people could be notified and asked to quarantine, ideally before they themselves became infectious (ie, contact tracing). [13][14][15][16][17] This supplemental issue of Public Health Reports provides firsthand examples of how public health departments across the United States reprioritized workflow and redirected staff to accommodate fluctuating COVID-19 incidence during 2020-2021, incorporated new partners to augment case investigation and contact tracing, evolved processes to improve outreach to disproportionately affected community groups, used digital tools for case and contact management and for proximity technology or exposure notification, and evaluated the effectiveness of these innovative strategies.