Rapid detection and quantitation of ketamine and norketamine in urine and oral fluid by wooden-tip electrospray ionization mass spectrometry

So, Pui‐Kin; Ng, Tsz Tsun; Wang, Haixing; Hu, Bin; Yao, Zhongping

doi:10.1039/c3an36641c

Cited by 68 publications

(60 citation statements)

References 34 publications

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“…Samples were loaded by pipetting onto the tip or dipping the tip into the sample solutions. This technique have been used for analysis of pharmaceuticals [58], ketamine and norketamine in urine and oral fluid [59], and Chinese herbal medicine preparations [60][61][62]. It has also been shown to act as a chromatographic column for separation of sample components, such as salts and proteins [63].…”

Section: Wooden Tipsmentioning

confidence: 99%

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

2016

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Paper spray mass spectrometry (MS) is part of a cohort of ambient ionization or direct analysis methods that seek to analyze complex samples without prior sample preparation. Extraction and electrospray ionization occur directly from the paper substrate upon which a dried matrix spot is stored. Paper spray MS is capable of detecting drugs directly from dried blood, plasma, and urine spots at the low ng/mL to pg/mL levels without sample preparation. No front end separation is performed, so tandem mass spectrometry (MS/MS) or high resolution MS is required. Here, we discuss paper spray methodology, give a comprehensive literature review of the use of paper spray MS for bioanalysis, discuss technological advancements and variations on this technique, and discuss some of its limitations. _________________________________________________________________________________ AbstractPaper spray mass spectrometry (MS) is part of a cohort of ambient ionization or direct analysis methods that seek to analyze complex samples without prior sample preparation. Extraction and electrospray ionization occur directly from the paper substrate upon which a dried matrix spot is stored. Paper spray MS is capable of detecting drugs directly from dried blood, plasma, and urine spots at the low ng/mL to pg/mL levels without sample preparation. No front end separation is performed, so tandem mass spectrometry (MS/MS) or high resolution MS is required. Here, we discuss paper spray methodology, give a comprehensive literature review of the use of paper spray MS for bioanalysis, discuss technological advancements and variations on this technique, and discuss some of its limitations.

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Section: Wooden Tipsmentioning

confidence: 99%

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

2016

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“…Wooden toothpicks have been frequently used as the substrates due to low cost and disposable features. 64) is approach has been applied for various applications, such as analysis of toxic substance in food samples, 65) drugs in urine and oral uid, 66) and metabolite ngerprinting. 67) In addition, wooden tip-based ESI was demonstrated for rapid analysis of pharmaceutical samples in various forms, including tablets, granules, capsules, suspensions and oral liquids.…”

Section: Wooden Substratesmentioning

confidence: 99%

Electrospray Modifications for Advancing Mass Spectrometric Analysis

Meher

Chen

2017

Mass Spectrometry

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Generation of analyte ions in gas phase is a primary requirement for mass spectrometric analysis. One of the ionization techniques that can be used to generate gas phase ions is electrospray ionization (ESI). ESI is a so ionization method that can be used to analyze analytes ranging from small organics to large biomolecules. Numerous ionization techniques derived from ESI have been reported in the past two decades.ese ion sources are aimed to achieve simplicity and ease of operation. Many of these ionization methods allow the exibility for elimination or minimization of sample preparation steps prior to mass spectrometric analysis. Such ion sources have opened up new possibilities for taking scienti c challenges, which might be limited by the conventional ESI technique. us, the number of ESI variants continues to increase. is review provides an overview of ionization techniques based on the use of electrospray reported in recent years. Also, a brief discussion on the instrumentation, underlying processes, and selected applications is also presented.

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“…Sequential and exhaustive ionization was also observed in wooden-tip ESI with an order di erent from that in PESI, 22) enabling separated ionization of salts and proteins thus direct analysis of protein samples with high salt content by the technique. 10) More recently, we demonstrated the application of woodentip ESI in direct detection and quantitation of drugs-ofabuse in raw oral uid and urine with acceptable sensitivity, linear range, accuracy and precision 42) (Figs. 4(c) & (d)).…”

Section: Wooden-tip Esimentioning

confidence: 99%

Electrospray Ionization on Solid Substrates

Yao

2014

Mass Spectrometry

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Development of electrospray ionization on solid substrates (solid-substrate ESI) avoids the clogging problem encountered in conventional capillary-based ESI, allows more convenient sampling and permits new applications. So far, solid-substrate ESI with various materials, e.g., metals, paper, wood, bers and biological tissue, has been developed, and applications ranging from analysis of pure compounds to complex mixtures as well as in vivo study were demonstrated. Particularly, the capability of solid-substrate ESI in direct analysis of complex samples, e.g., biological uids and foods, has signi cantly facilitated mass spectrometric analysis in real-life applications and led to increasingly important roles of these techniques nowadays. In this review, various solid-substrate ESI techniques and their applications are summarized and the prospects in this eld are discussed.Please cite this article as: P.-K. So, et al., Electrospray Ionization on Solid Substrates, Mass Spectrom (Tokyo) 2014; 3(2): S0028;

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Rapid detection and quantitation of ketamine and norketamine in urine and oral fluid by wooden-tip electrospray ionization mass spectrometry

Cited by 68 publications

References 34 publications

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

Electrospray Modifications for Advancing Mass Spectrometric Analysis

Electrospray Ionization on Solid Substrates

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