Rapid detection of antibodies in skin interstitial fluid via fluorescent testing using antigen-modified porous microneedles

Xu, Mengxin; Liu, Ying; Chen, Huimin; Hu, Weilun; Li, Yingying; Zhang, Yuxin; Wang, Qingqing; Ma, Tao

doi:10.1016/j.colsurfa.2024.133987

Colloids and Surfaces A: Physicochemical and Engineering Aspect

2024

DOI: 10.1016/j.colsurfa.2024.133987

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Rapid detection of antibodies in skin interstitial fluid via fluorescent testing using antigen-modified porous microneedles

Mengxin Xu,

Ying Liu,

Huimin Chen

et al.

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2024

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Cited by 2 publications

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Engineering the Functional Expansion of Microneedles

Yang,

Xu,

Zhu

et al. 2024

Advanced Materials

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Microneedles (MNs), composed of an array of micro‐sized needles and a supporting base, have transcended their initial use to replace hypodermic needles in drug delivery and fluid collection, advancing toward multifunctional platforms. In this review, four major areas are summarized in interdisciplinary engineering approaches combined with MNs technology. First, electronics engineering, the most extensively researched field, enables applications in biomonitoring, electrical stimulation, and closed‐loop theranostics through the generation, transmission, and transformation of electrical signals. Second, in electromagnetic engineering, the responsiveness of electromagnetic induction offers prospects for remote and programmable therapeutic applications. Third, photonic engineering endows MNs with novel functionalities, such as waveguiding and photonic manipulation to enhance optical therapeutic capabilities and facilitate the visualization of disease progression and treatment processes. Lastly, it reviewed the role of mechanical engineering in conferring shape adaptability and programmable motion features necessary for various MNs applications. This review focuses on the functionalities that emerge from the intersection of MNs with complementary engineering technologies, aiming to inspire further research and innovation in microneedle technology for biomedical applications.

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Engineering the Functional Expansion of Microneedles

Yang,

Xu,

Zhu

et al. 2024

Advanced Materials

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Lateral Flow-Based Skin Patch for Rapid Detection of Protein Biomarkers in Human Dermal Interstitial Fluid

Wilkirson,

Li,

Lillehoj

2024

ACS Sens.

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Rapid diagnostic tests (RDTs) offer valuable diagnostic information in a quick, easy-to-use and low-cost format. While RDTs are one of the most commonly used tools for in vitro diagnostic testing, they require the collection of a blood sample, which is painful, poses risks of infection and can lead to complications. We introduce a blood-free point-of-care diagnostic test for the rapid detection of protein biomarkers in dermal interstitial fluid (ISF). This device consists of a lateral flow immunochromatographic assay (LFIA) integrated within a microfluidic skin patch. ISF is collected from the skin using a microneedle array and vacuum-assisted extraction system integrated in the patch, and transported through the lateral flow strip via surface tension. Using this skin patch platform, we demonstrate in situ detection of anti-tetanus toxoid IgG and SARS-CoV-2 neutralizing antibodies, which could be accurately detected in human ISF in <20 min. We envision that this device can be readily modified to detect other protein biomarkers in dermal ISF, making it a promising tool for rapid diagnostic testing.

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Rapid detection of antibodies in skin interstitial fluid via fluorescent testing using antigen-modified porous microneedles

Cited by 2 publications

References 32 publications

Engineering the Functional Expansion of Microneedles

Engineering the Functional Expansion of Microneedles

Lateral Flow-Based Skin Patch for Rapid Detection of Protein Biomarkers in Human Dermal Interstitial Fluid

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