Rapid Detection of Bloodstream Pathogens in Oncologic Patients with a FilmArray Multiplex PCR Assay: a Comparison with Culture Methods

Szymankiewicz, Maria; Nakonowska, Beata

doi:10.5604/01.3001.0011.6149

Cited by 4 publications

(4 citation statements)

References 16 publications

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Section: Diagnostic Stewardshipmentioning

confidence: 99%

“…4,63 Although 2 studies have validated the use of matrix-assisted laser desorption/ ionization time-of-flight and multiplex polymerase chain reaction (PCR), specifically BioFire FilmArray blood culture identification (BCID), in oncology patients, there are limited data that demonstrate the clinical impact of RDTs in this population. 64,65 A retrospective cohort study conducted by Seo et al 66 evaluated the impact of active ASP combined with Staphylococcus QuickFISH on initiation and duration of vancomycin in oncology patients. Of the 684 patients with a positive blood culture and Gram-positive cocci in clusters, 299 were identified as likely contaminants because of coagulase-negative Staphylococcus (CoNS).…”

Section: Rapid Diagnostic Testingmentioning

confidence: 99%

See 1 more Smart Citation

Inpatient Antibiotic Stewardship Interventions in the Adult Oncology and Hematopoietic Stem Cell Transplant Population: A Review of the Literature

et al. 2019

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Objective: To review the use of antibiotic stewardship interventions in the adult oncology and hematopoietic cell transplantation (HCT) populations. Data Sources: A literature search of PubMed was performed from inception to October 31, 2019. The general search terms used were oncology, cancer, hematologic malignancy, antimicrobial stewardship, antibiotic stewardship, febrile neutropenia, neutropenic fever, de-escalation, discontinuation, prophylaxis, practice guidelines, clinical pathway, rapid diagnostics, Filmarray, Verigene, MALDI-TOF, antibiotic allergy, and antimicrobial resistance. Study Selection and Data Extraction: Relevant English-language studies describing interventions supported by the Infectious Diseases Society of America guidelines on “Implementing an Antibiotic Stewardship Program” were included. Data Synthesis: Antibiotic stewardship publications in the oncology population have increased in recent years. Studies have described the impact of stewardship interventions, including preauthorization, prospective audit and feedback, implementation of clinical pathways, de-escalation of empirical antibiotics for febrile neutropenia (FN) prior to neutrophil recovery, allergy assessments, and use of rapid diagnostic testing. Many of these interventions have been shown to decrease antibiotic use without increased negative consequences, such as affecting length of stay or mortality. Relevance to Patient Care and Clinical Practice: This review synthesizes available evidence for implementing antibiotic stewardship interventions, particularly de-escalation of antibiotics for FN and implementation of clinical pathways for FN and sepsis, in oncology patients and HCT recipients. Summary tables highlight studies and specific research needs for clinicians. Conclusions: Immunocompromised populations, including oncology patients, have often been excluded from stewardship studies. Antibiotic stewardship is effective in reducing antibiotic consumption and improving outcomes in this patient population, although more quality data are needed.

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Section: Diagnostic Stewardshipmentioning

confidence: 99%

Section: Rapid Diagnostic Testingmentioning

confidence: 99%

Inpatient Antibiotic Stewardship Interventions in the Adult Oncology and Hematopoietic Stem Cell Transplant Population: A Review of the Literature

et al. 2019

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“…The clinical impact on cancer patients from rapid microbiological diagnostic tests, for example BioFire ® FilmArray ® sepsis panel (BCID) or MALDITOF (Matrix Assisted Laser Desorption Ionization—Time of Flight Mass Spectrometry), have limited data [ 25 , 26 ]. A quasi-experimental study reported by Buss et al [ 27 ] analyzed the impact of BCID in treating bacteremia in cancer patients over a 4-year period.…”

Section: Discussionmentioning

confidence: 99%

Impact of Adding a Rapid PCR-Based Blood Culture Identification Panel to the Antimicrobial Stewardship Program of Patients with Febrile Neutropenia in a Peruvian Referral Hospital

et al. 2023

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The addition of Biofire® FilmArray® Blood Culture Identification panel 2 (BCID2) to the antimicrobial stewardship program (ASP) could improve outcomes in bloodstream infections (BSI) of patients with febrile neutropenia (FN). A pre- and post-quasi-experimental single-center study was conducted at a reference hospital in Peru. Three groups were considered: patients with BSI before ASP intervention (control group), patients with BSI after ASP intervention (group 1), and patients with BSI after ASP intervention plus BCID2 PCR Panel implementation (group 2). Overall, 93 patients were identified (32 control, 30 group 1, 31 group 2). The median time to effective therapy was significantly shorter in group 2 compared to group 1 and control group, respectively (3.75 vs. 10 h, p = 0.004; 3.75 vs. 19 h, p < 0.001). No significant differences in terms of relapse of bacteremia, in-hospital mortality (all cause), and 30-day-all-cause hospital readmission between the three study periods were found. The appropriateness of empirical antimicrobial use, adding or change, and the following de-escalation or discontinuation was significant when the two intervention periods were compared with the control group (p < 0.001). In addition to the lack of local studies documenting the microbiological profile of FN episodes, adding syndromic panels-based testing could allow for the consolidation of ASP strategies.

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“…FILMArray Blood Culture Identification Panel (BioFire Diagnostics, Salt Lake City, UT) uses a PCR strategy to screen for a panel of 24 bacterial and fungal pathogens, and 3 antibacterial resistance genes, from positive blood cultures, with strong performance against reference standards and a turnaround time of around 1 hour. 4,[117][118][119] It has also been used to directly examine CSF and bronchoalveolar lavage samples, without the need to wait for positive cultures. 118,120…”

Section: Culture-based Technologiesmentioning

confidence: 99%

Management of Multidrug-Resistant Infections in Cirrhosis

Gallaher

Shawcross

2022

Semin Liver Dis

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The World Health Organization describes antimicrobial resistance (AMR) as one of the biggest threats to global health, food security, and development with indiscriminate use of antimicrobials globally driving the emergence of multidrug-resistant bacteria, resistant to 60% of antimicrobials in some countries. Infections with multi-drug resistant organisms (MDROs) have increased in recent decades in patients with cirrhosis, who are frequently prescribed antibiotics, regularly undergo invasive procedures such as large volume paracentesis and have recurrent hospitalizations, posing a particular risk in this already immunocompromised cohort of patients. In this review, we explore mechanisms underlying this vulnerability to MDRO infection; the effect of bacterial infections on disease course in cirrhosis; prevalence of MDROs in patients with cirrhosis; outcomes following MDRO infection; fungal infections; antibiotics and their efficacy; and management of MDRO infections in terms of detection, antimicrobial and non-antimicrobial treatments, prophylaxis, antibiotic stewardship, the gut microbiome, and technological interventions.

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Rapid Detection of Bloodstream Pathogens in Oncologic Patients with a FilmArray Multiplex PCR Assay: a Comparison with Culture Methods

Cited by 4 publications

References 16 publications

Inpatient Antibiotic Stewardship Interventions in the Adult Oncology and Hematopoietic Stem Cell Transplant Population: A Review of the Literature

Inpatient Antibiotic Stewardship Interventions in the Adult Oncology and Hematopoietic Stem Cell Transplant Population: A Review of the Literature

Impact of Adding a Rapid PCR-Based Blood Culture Identification Panel to the Antimicrobial Stewardship Program of Patients with Febrile Neutropenia in a Peruvian Referral Hospital

Management of Multidrug-Resistant Infections in Cirrhosis

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