Rapid detection of<i>mycobacterium tuberculosis</i>from MODS culture by PCR

Peter, Simona; Cernomaz, Andrei Tudor; Rusu-Cordunean, Florin; Macovei, Ina-Iuliana; Pavel, Ionut; Zonda, Radu; Grigoriu, Bogdan-Dragos

doi:10.1183/13993003.congress-2016.pa1908

Cited by 1 publication

(1 citation statement)

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“…New approaches have also been reported, like FASTPlaque-response bacteriophage assay (Minion and Pai, 2010 ), microscopic observation drug susceptibility assay (MODS) (Peter et al, 2016 ), use of dyes to monitor bacterial growth (Coban et al, 2016 ), sequencing and hybridization, reverse hybridization, direct sequencing (Deggim-Messmer et al, 2016 ), TB Biochip platform (Xue et al, 2016 ) and other molecular approaches. Each method was proposed to provide faster as well as more reliable results for early detection of drug-resistance.…”

Section: Clinical Diagnosis Of Dr-tbmentioning

confidence: 99%

Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains

Hameed

Islam

Chhotaray

et al. 2018

Front. Cell. Infect. Microbiol.

139

131

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Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death worldwide today. Escalating application of genomic techniques has expedited the identification of increasing number of mutations associated with drug resistance in Mycobacterium tuberculosis. Unfortunately the prevalence of bacillary resistance becomes alarming in many parts of the world, with the daunting scenarios of multidrug-resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) and total drug-resistant tuberculosis (TDR-TB), due to number of resistance pathways, alongside some apparently obscure ones. Recent advances in the understanding of the molecular/ genetic basis of drug targets and drug resistance mechanisms have been steadily made. Intriguing findings through whole genome sequencing and other molecular approaches facilitate the further understanding of biology and pathology of M. tuberculosis for the development of new therapeutics to meet the immense challenge of global health.

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