Rapid detection of influenza A virus in clinical samples using an ion channel switch biosensor

Oh, S.Y.; Cornell, Bruce; Smith, David K.; Higgins, G.; Burrell, Christopher J.; Kok, Tuckweng

doi:10.1016/j.bios.2007.10.011

Cited by 36 publications

(14 citation statements)

References 29 publications

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“…Oh biosensor that could detect influenza A virus in clinical samples within 10 min after the sample was inoculated into chamber wells. This biosensor could obtain comparable results in sensitivity and reproducibility without sample pretreatment (Oh et al, 2008). A poly-silicon nanowire field-effect transistor was reported for specific and ultrasensitive detection of AI H5 virus DNA (Lin et al, 2009).…”

Section: Introductionmentioning

confidence: 96%

An impedance immunosensor based on low-cost microelectrodes and specific monoclonal antibodies for rapid detection of avian influenza virus H5N1 in chicken swabs

Lin

Wang

Jiao

et al. 2015

Biosensors and Bioelectronics

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Section: Introductionmentioning

confidence: 96%

An impedance immunosensor based on low-cost microelectrodes and specific monoclonal antibodies for rapid detection of avian influenza virus H5N1 in chicken swabs

Lin

Wang

Jiao

et al. 2015

Biosensors and Bioelectronics

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“…The ion-channel switch has since demonstrated specific signals derived from interactions with a range of analytes including bacteria, DNA, proteins and drugs [60]. Recently, Oh et al [61] reported the detection of influenza A virus in clinical samples using the ion-channel switch biosensor.…”

Section: Ion-channel Switchmentioning

confidence: 98%

Nanoscale Biosensors and Biochips

Leifert

Glatz

Bailey

et al. 2009

Annual Review of Nano Research

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“…Modified gramicidin was also developed as a key element of a biosensor, composed of a tethered bilayer on a solid support, the a system combining biological recognition mechanism with physical transduction [178,179,180,181]. In this application, modified GrA serves as the signal transducer: single molecule binding to its engineered domain modulates ability of the transmembrane pores to dimerize and to pass ion current.…”

Section: Channel Forming Bacterial Toxins For Molecular Sensingmentioning

confidence: 99%

Channel-Forming Bacterial Toxins in Biosensing and Macromolecule Delivery

Gurnev

Nestorovich

2014

Toxins

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To intoxicate cells, pore-forming bacterial toxins are evolved to allow for the transmembrane traffic of different substrates, ranging from small inorganic ions to cell-specific polypeptides. Recent developments in single-channel electrical recordings, X-ray crystallography, protein engineering, and computational methods have generated a large body of knowledge about the basic principles of channel-mediated molecular transport. These discoveries provide a robust framework for expansion of the described principles and methods toward use of biological nanopores in the growing field of nanobiotechnology. This article, written for a special volume on “Intracellular Traffic and Transport of Bacterial Protein Toxins”, reviews the current state of applications of pore-forming bacterial toxins in small- and macromolecule-sensing, targeted cancer therapy, and drug delivery. We discuss the electrophysiological studies that explore molecular details of channel-facilitated protein and polymer transport across cellular membranes using both natural and foreign substrates. The review focuses on the structurally and functionally different bacterial toxins: gramicidin A of Bacillus brevis, α-hemolysin of Staphylococcus aureus, and binary toxin of Bacillus anthracis, which have found their “second life” in a variety of developing medical and technological applications.

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Rapid detection of influenza A virus in clinical samples using an ion channel switch biosensor

Cited by 36 publications

References 29 publications

An impedance immunosensor based on low-cost microelectrodes and specific monoclonal antibodies for rapid detection of avian influenza virus H5N1 in chicken swabs

An impedance immunosensor based on low-cost microelectrodes and specific monoclonal antibodies for rapid detection of avian influenza virus H5N1 in chicken swabs

Nanoscale Biosensors and Biochips

Channel-Forming Bacterial Toxins in Biosensing and Macromolecule Delivery

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