Rapid Detection of Intracellular p47phox and p67phox by Flow Cytometry; Useful Screening Tests for Chronic Granulomatous Disease

Wada, Taizo; Muraoka, Masahiro; Toma, Tomoko; Imai, Tsuyoshi; Shigemura, Tomonari; Agematsu, Kazunaga; Haraguchi, Kohei; Moriuchi, Hiroyuki; Oh‐ishi, Tsutomu; Kitoh, Toshiyuki; Ohara, Osamu; Morio, Tomohiro; Yachie, Akihiro

doi:10.1007/s10875-012-9859-9

Cited by 22 publications

(20 citation statements)

References 23 publications

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“…The role of molecular testing in CGD diagnosis and genetic counseling can be limited with the availability of the needed facilities and expertise in testing laboratories . Identification of CGD subgroups by flow cytometry has been an interest of Wada et al who demonstrated that p47 phox and p67 phox subunits can be analyzed by flow cytometry. These techniques can represent an important secondary screening test for CGD and can be utilized to predict underlying genetic mutations and direct molecular testing.…”

Section: Discussionmentioning

confidence: 99%

Correlation between flow cytometry and molecular findings in autosomal recessive chronic granulomatous disease: A cohort study from Oman

Al-Riyami

Al-Zadjali

Al-Mamari

et al. 2018

Int J Lab Hematology

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Section: Discussionmentioning

confidence: 99%

Correlation between flow cytometry and molecular findings in autosomal recessive chronic granulomatous disease: A cohort study from Oman

Al-Riyami

Al-Zadjali

Al-Mamari

et al. 2018

Int J Lab Hematology

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“…Cytoplasmic flow cytometric methods to detect phagocyte oxidase subunits have been developed but are not yet generally available. 539 Ultimate confirmation is done by testing for the genetic mutation in the genes that make up the NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase complex (gp91phox, p22phox, p47phox, p67phox, and p40phox). 540 Summary statement 153.…”

Section: Defects Of the Respiratory Burst Chronic Granulomatous Disementioning

confidence: 99%

Practice parameter for the diagnosis and management of primary immunodeficiency

Bernstein¹,

Blessing-Moore²,

Khan³

et al. 2015

Journal of Allergy and Clinical Immunology

584

494

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The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for establishing the "Practice parameter for the diagnosis and management of primary immunodeficiency." This is a complete and comprehensive document at the current time. The medical environment is a changing environment, and not all recommendations will be appropriate for all patients. Because this document incorporated the efforts of many participants, no single individual, including those who served on the Joint Task Force, is authorized to provide an official AAAAI or ACAAI interpretation of these practice parameters. Any request for information about or an interpretation of these practice parameters by the AAAAI or ACAAI should be directed to the Executive Offices of the AAAAI, the ACAAI, and the Joint Council of Allergy, Asthma & Immunology. These parameters are not designed for use by pharmaceutical companies in drug promotion.

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“…The detection of LPS‐induced monocyte cell death is useful for rapid diagnosis of CAPS . Intracellular staining is a useful tool for rapid diagnosis of FHL and CGD .…”

Section: Current Treatment Approachesmentioning

confidence: 99%

Pediatric allergy and immunology in Japan

Ebisawa

Nishima

Ohnishi

et al. 2013

Pediatric Allergy Immunology

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The Japanese Society of Pediatric Allergy and Clinical Immunology (JSPACI) was started in 1966 and currently has 3613 members as of August 1, 2012. The number of pediatricians specializing in allergies who have been certified by the Japanese Society of Allergology is 817. Among these, there are 125 training directors and training facilities for allergy and clinical immunology. The JSPACI first published an asthma guideline specific for children in 2000, and this has been revised every 3 yrs, contributing to better control of pediatric asthma. Food allergy management guidelines were first developed in 2005, which have helped to improve the care of food allergy patients. Among 514 pediatric training programs by the Japanese Society of Pediatrics, there are 312 facilities routinely performing oral food challenges. Among these, there were already 53 facilities performing oral immunotherapy at the end of 2011, treating 1400 cases of food allergy. The prevalence of pediatric allergic diseases has increased in Japan over the past 50 yrs. A number of International Study of Asthma and Allergies in Childhood surveys have been conducted in the past at specific times. The prevalence of wheezing among children aged 13–14 yrs in 2002 was 13.0%. Multi‐year surveys found a 1.5‐ to 2‐fold increase every 10 yrs until 2002. However, according to the latest data in 2012, asthma prevalence seems to have slightly decreased in Japan. Food allergy mainly associated with infantile atopic eczema among infants younger than 1 yr of age is the most common form as with other developed countries. The estimated food allergy prevalence based on data from several surveys is 5–10% among infants (0–6 yrs) and 1–2% among schoolchildren (6–15 yrs). A variety of patients suffering from primary deficiency syndrome have been actively analyzed. Previously, antibody defects and well‐defined syndromes with immunodeficiency were analyzed, but recent research is focusing on not only acquired immune disorders but also on innate immune disorders. In contrast to the widespread use of oral immunotherapy, one immediate issue is to develop and reassess subcutaneous and sublingual immunotherapies for mite and Japanese cedar pollen antigens that have been disused in Japan since the 1990s.

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Rapid Detection of Intracellular p47phox and p67phox by Flow Cytometry; Useful Screening Tests for Chronic Granulomatous Disease

Cited by 22 publications

References 23 publications

Correlation between flow cytometry and molecular findings in autosomal recessive chronic granulomatous disease: A cohort study from Oman

Correlation between flow cytometry and molecular findings in autosomal recessive chronic granulomatous disease: A cohort study from Oman

Practice parameter for the diagnosis and management of primary immunodeficiency

Pediatric allergy and immunology in Japan

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