Rapid detection of perfluorinated sulfonic acids through preconcentration by bubble bursting and surface‐assisted laser desorption/ionization

Lee, Chuping; Yang, Tzu-Ling; Yao, Yu-Zhen; Li, Jianyou; Huang, Cheng‐Liang

doi:10.1002/jms.4667

Cited by 7 publications

(4 citation statements)

References 28 publications

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“…The noticeable bubbling extraction prior to microbubble bursting ionization improves sensitivity and affords lower limits of detection (LODs). − ,− As shown in Figure S5, a widely used synthetic compound, perfluorooctanoic acid (PFOA), at the level of pg/mL, could be detected using our method. The LOD was determined as 1 pg/mL, and the linearity was good ( R 2 > 0.99) at the concentration range of 1–1000 ng/mL.…”

Section: Resultsmentioning

confidence: 99%

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Carbon Dioxide Microbubble Bursting Ionization Mass Spectrometry

Gao

Guo

et al. 2022

Anal. Chem.

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Aerosols generated by bubble bursting have been proved to promote the extraction of analytes and have ultrahigh electric fields at their water–air interfaces. This study presented a simple and efficient ionization method, carbon dioxide microbubble bursting ionization (CDMBI), without the presence of an exogenous electric field (namely, zero voltage), by simulating the interfacial chemistries of sea spray aerosols. In CDMBI, microbubbles are generated in situ by continuous input of carbon dioxide into an aqueous solution containing low-concentration analytes. The microbubbles extract low- and high-polarity analytes as they pass through the aqueous solution. Upon reaching the water–air interface, these microbubbles burst to produce charged aerosol microdroplets with an average diameter of 260 μm (8.1–10.4 nL in volume), which are immediately transferred to a mass spectrometer for the detection and identification of extracted analytes. The above analytical process occurs every 4.2 s with a stable total ion chromatogram (relative standard deviation: 9.4%) recorded. CDMBI mass spectrometry (CDMBI-MS) can detect surface-active organic compounds in aerosol microdroplets, such as perfluorooctanoic acid, free fatty acids epoxidized by bubble bursting, sterols, and lecithins in soybean and egg, with the limit of detection reaching the level of fg/mL. In addition, coupling CDMBI-MS with an exogenous voltage yields relatively weak gains in ionization efficiency and sensitivity of analysis. The results suggested that CDMBI can simultaneously accomplish both bubbling extraction and microbubble bursting ionization. The mechanism of CDMBI involves bubbling extraction, proton transfer, inlet ionization, and electrospray-like ionization. Overall, CDMBI-MS can work in both positive and negative ion modes without necessarily needing an exogenous high electric field for ionization and quickly detect trace surface-active analytes in aqueous solutions.

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Section: Resultsmentioning

confidence: 99%

“…Subsequently, the bubbles extract analytes in the solution and rise to the water–air interface to burst to generate analyte-containing aerosols. The aerosols are collected or vaporized and then sent to a mass spectrometer for analysis. − …”

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confidence: 99%

Carbon Dioxide Microbubble Bursting Ionization Mass Spectrometry

Gao

Guo

et al. 2022

Anal. Chem.

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“…The background interference from small organic matrices in the low‐mass range is a common problem in MALDI. To address this problem, metal nanoparticles (e.g., silver and gold), metal oxide nanoparticles (e.g., titanium dioxide), and materials with porous surfaces (e.g., porous silicon microparticles and metal–organic frameworks) have been reported as alternatives to typical organic matrices (the technique using these alternatives is called surface‐assisted laser desorption/ionization) (Dutkiewicz et al, 2021; C. Lee & Ni, 2019; C. Lee et al, 2021; T.‐L. Yang et al, 2021).…”

Section: Msi Methodsmentioning

confidence: 99%

Next‐generation pathology practices with mass spectrometry imaging

Chung

Huang

Chen

et al. 2022

Mass Spectrometry Reviews

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Mass spectrometry imaging (MSI) is a powerful technique that reveals the spatial distribution of various molecules in biological samples, and it is widely used in pathology‐related research. In this review, we summarize common MSI techniques, including matrix‐assisted laser desorption/ionization and desorption electrospray ionization MSI, and their applications in pathological research, including disease diagnosis, microbiology, and drug discovery. We also describe the improvements of MSI, focusing on the accumulation of imaging data sets, expansion of chemical coverage, and identification of biological significant molecules, that have prompted the evolution of MSI to meet the requirements of pathology practices. Overall, this review details the applications and improvements of MSI techniques, demonstrating the potential of integrating MSI techniques into next‐generation pathology practices.

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“…Various nanomaterials have highly selective signal enhancement; therefore, different nanomaterials are suitable for detecting different analytes. For example, silver nanoparticles (AgNPs) can be employed to detect perfluorinated sulfonic acid in environment pollution [ 25 ] and TAG in brain tissue [ 26 ]. In contrast, gold nanoparticles can be used to detect aminothiols during metabolic disease diagnosis [ 27 ] and mercury telluride nanomaterials (HgTe) for glycoconjugate detection [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Utilizing AgNPt-SALDI to Classify Edible Oils by Multivariate Statistics of Triacylglycerol Profile

2021

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Edible oils are valuable sources of nutrients, and their classification is necessary to ensure high quality, which is essential to food safety. This study reports the establishment of a rapid and straightforward SALDI-TOF MS platform used to detect triacylglycerol (TAG) in various edible oils. Silver nanoplates (AgNPts) were used to optimize the SALDI samples for high sensitivity and reproducibility of TAG signals. TAG fingerprints were combined with multivariate statistics to identify the critical features of edible oil discrimination. Eleven various edible oils were discriminated using principal component analysis (PCA). The results suggested the creation of a robust platform that can examine food adulteration and food fraud, potentially ensuring high-quality foods and agricultural products.

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Rapid detection of perfluorinated sulfonic acids through preconcentration by bubble bursting and surface‐assisted laser desorption/ionization

Cited by 7 publications

References 28 publications

Carbon Dioxide Microbubble Bursting Ionization Mass Spectrometry

Carbon Dioxide Microbubble Bursting Ionization Mass Spectrometry

Next‐generation pathology practices with mass spectrometry imaging

Utilizing AgNPt-SALDI to Classify Edible Oils by Multivariate Statistics of Triacylglycerol Profile

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