Rapid determination of benzalkonium chloride in pharmaceutical preparations with flow injection liquid—liquid extraction

Halvax, J.J.; Wiese, G.; Arp, Jan; Vermeer, J. M.; Bennekom, W.P. van; Bult, A.

doi:10.1016/0731-7085(90)80033-l

Cited by 17 publications

(7 citation statements)

References 19 publications

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“…46,47 Its ability to form ion-pairs with bulky anions has been used in liquid-liquid extraction methods for its determination. 48 (c Co = 4.0 × 10 -4 mol dm -3 ) were prepared by appropriate dilution. MTAR (95%) and BZC (≥ 95%) were also Merck products.…”

Section: Introductionmentioning

confidence: 99%

Extraction-Chromogenic System for Cobalt Based on 5-Methyl-4-(2-thiazolylazo) Resorcinol and Benzalkonium Chloride

Hristov

Racheva

Toncheva

et al. 2021

ACSi

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The interaction between CoII and 5-methyl-4-(2-thiazolylazo)-resorcinol (MTAR) was studied in a water-chloroform system, in the presence or absence of benzalkonium chloride (BZC) as a cationic ion-association reagent. The optimum pH, concentration of the reagents and extraction time for the extraction of Co were found. In the presence of BZC, the extracted ion-associate could be represented by the formula (BZ+)[CoIII(MTAR2–)2], where MTAR is in its deprotonated form. The following extraction-spectrophotometric characteristics were determined: absorption maximum, molar absorptivity, Sandell’s sensitivity, limit of detection, limit of quantification, constant of extraction, distribution ratio and fraction extracted. In the absence of BZC, the extraction is incomplete and occurs in a narrow pH range. The extracted chelate contains one deprotonated and one monoprotonated ligand: [CoIII(MTAR2–)(HMTAR–)].

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Section: Introductionmentioning

confidence: 99%

Extraction-Chromogenic System for Cobalt Based on 5-Methyl-4-(2-thiazolylazo) Resorcinol and Benzalkonium Chloride

Hristov

Racheva

Toncheva

et al. 2021

ACSi

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“…Alternatively, cetrimide (197c) and cetylpyridinium chloride were determined in industrial and consumer products, by indirect adsorptive stripping voltametry on a dropping mercury electrode 425 . A rapid method for benzalkonium chloride (197b) in pharmaceutical preparations was based on LLE of the picrate into chloroform in an FIA system and determination of the anion 426 .…”

Section: B Miscellaneous Methodsmentioning

confidence: 99%

Analytical Aspects of Amino, Quaternary Ammonium, Nitro, Nitroso and Related Functional Groups

Zabicky

Bittner

2009

Patai's Chemistry of Functional Groups

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“…Benzalkonium chloride is a mixture of n-alkyl benzyldimethyl ammonium chloride homologs, where n represents an even number of carbons from C8 to C18. The most common homologs are C12, C14, and C16 [3], the biocidal properties of the individual homologs are known to be different [4]. Benzyldimethyltetradecylammonium chloride (molecular formula: C23H42ClN, molecular weight: 368.04 g/mol) is a cationic surfactant used as a disinfectant and sanitizer and also as a wood preservative.…”

Section: Fig 2 Structure Of Benzalkonium Chloridementioning

confidence: 99%

Impact of various surfactant classes on the microorganism community used for WWTP biodegradation treatment

Mitru¹,

Lucaciu²,

Niță-Lazăr³

et al. 2020

RJEEC

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Environmental pollution is an important issue influencing human health and environmental equilibrium. The range of pollutants is very wide due to industrialization and population growth and the surfactants are one of the most common organic pollutants due to their extensive use and ubiquitous presence from industry to households. Their massive presence in the domestic and industrial wastewater could affect the Wastewater treatment plants by inhibiting the activated sludge used in pollutants biodegradation treatment step. This paper aimed to study the inhibition effect of three classes of surfactants (nonionic, anionic, and cationic) by measuring the respiratory activity of microorganisms with the application of the Oxygen Uptake Rate (OUR) test. This study established that the surfactants could activate or inhibit microorganisms’ activity, depending on surfactant concentration.

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Rapid determination of benzalkonium chloride in pharmaceutical preparations with flow injection liquid—liquid extraction

Cited by 17 publications

References 19 publications

Extraction-Chromogenic System for Cobalt Based on 5-Methyl-4-(2-thiazolylazo) Resorcinol and Benzalkonium Chloride

Extraction-Chromogenic System for Cobalt Based on 5-Methyl-4-(2-thiazolylazo) Resorcinol and Benzalkonium Chloride

Analytical Aspects of Amino, Quaternary Ammonium, Nitro, Nitroso and Related Functional Groups

Impact of various surfactant classes on the microorganism community used for WWTP biodegradation treatment

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