Rapid determination of the metabolic pool of ethyl loflazepate in biological fluids by capillary gas chromatography

Ba, Burrows; Bun, H.; Coassolo, Philippe; Cano, Jean Paul

doi:10.1016/0731-7085(86)80013-9

Search citation statements

Order By: Relevance

Paper Sections

Select...

Analytical Methodology and Expression Of Results1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1989

Publication Types

Select...

Article2

Relationship

Self Cite1

Independent1

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Plasma and urine EL metabolites were determined by a gas chromatographic technique (Ba et al, 1986).…”

Section: Analytical Methodology and Expression Of Resultsmentioning

confidence: 99%

EFFECT OF RENAL FAILURE ON THE PHARMACOKINETICS OF ETHYL LOFLAZEPATE (Victan®) IN MAN

Iliadis

Durand

et al. 1989

Fundamemntal Clinical Pharma

Self Cite

View full text Add to dashboard Cite

The kinetics of ethyl loflazepate were studied in patients with various degrees of renal failure. A strong correlation was noted between urinary excretion of metabolite loflazepate and creatinine clearance. In contrast, elimination half-life and total plasma clearance of the sum of loflazepate + descarboxyloflazepate seemed to be independent of the degree of renal impairment. These results indicate the absence of a risk of accumulation of the 2 main and active metabolites of ethyl loflazepate in patients with renal failure.

show abstract

“…Plasma and urine EL metabolites were determined by a gas chromatographic technique (Ba et al, 1986).…”

Section: Analytical Methodology and Expression Of Resultsmentioning

confidence: 99%

EFFECT OF RENAL FAILURE ON THE PHARMACOKINETICS OF ETHYL LOFLAZEPATE (Victan®) IN MAN

Iliadis

Durand

et al. 1989

Fundamemntal Clinical Pharma

Self Cite

View full text Add to dashboard Cite

show abstract

Pharmacokinetic modeling of ethyl loflazepate (VictanR) and its main active metabolites

1989

View full text Add to dashboard Cite

A simultaneous consideration of plasma and urine data of unchanged drug and active metabolites, taking into account the metabolic process of the precursor, is described. The maximum likelihood principle was used to estimate parameters. This methodology is highly efficient in determining the contribution of the two main and active metabolites in the pharmacological response of ethyl loflazepate. It also may serve in the search for optimum dosage regimens in clinical practice.

show abstract

Rapid determination of the metabolic pool of ethyl loflazepate in biological fluids by capillary gas chromatography

Cited by 2 publications

References 12 publications

EFFECT OF RENAL FAILURE ON THE PHARMACOKINETICS OF ETHYL LOFLAZEPATE (Victan®) IN MAN

EFFECT OF RENAL FAILURE ON THE PHARMACOKINETICS OF ETHYL LOFLAZEPATE (Victan®) IN MAN

Pharmacokinetic modeling of ethyl loflazepate (VictanR) and its main active metabolites

Contact Info

Product

Resources

About