Rapid Determination of the Primary Alkaloids in Illicit Heroin by High-Performance Liquid Chromatography with Tandem Mass Spectrometry (HPLC–MS/MS)

Jovanov, Pavle; Petrin-Miličević, Marija; Radosavljevic-Stevanovic, Natasa; Belić, Sanja; Sakač, Marijana; Nikolov, Jovana; Gadžurić, Slobodan

doi:10.1080/00032719.2020.1798454

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…As seen in Figure 5G, the coefficient of determination R 2 was 0.86. In a study conducted in 2020 by Jovanov et al, 46 which presented a rapid method for detecting heroin using HPLC−MS/MS, an LOD and LOQ were obtained from calibration curves of a 0.4 μg/mL heroin standard solution.…”

Section: Quantification Resultsmentioning

confidence: 99%

Fiber Laser-Generated Silver-109 Nanoparticles for Laser Desorption/Ionization Mass Spectrometry of Illicit Drugs

Krupa,

Nizioł

2024

J. Am. Soc. Mass Spectrom.

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Cannabinoids and opioids are the most prominently used drugs in the world, with fentanyl being the main cause of drug overdose-related deaths. Monitoring drug use in groups as well as in individuals is an important forensic concern. Analytical methods, such as mass spectrometry (MS), have been found most useful for the identification of drug abuse on a small and large scale. Pulsed fiber laser 2D galvoscanner laser-generated nanomaterial (PFL 2D GS LGN) was obtained from monoisotopic silver-109. Nanomaterial was used for laser desorption/ionization mass spectrometry of selected illicit drug standards with standard highresolution reflectron-based time-of-flight MALDI apparatus. Δ 9 -THC, 11-OH-THC, 11-COOH-THC, fentanyl, codeine, 6-monoacetylmorphine (6-MAM), heroin, tramadol, and methadone were chosen as test compounds. Illicit drugs were tested in a concentration range from 100 μg/mL to 10 pg/mL, equating to 50 μg to 50 fg per measurement spot. For all analyzed compounds, identification and quantification by silver-109-assisted laser desorption/ionization (LDI) MS was possible, with uncommon [M + 109 Ag 3 ] + and [M − H] + ions present for certain structures. The results of the quantitative analysis of drugs using silver-109 PFL 2D GS LGN for LDI MS are presented. Laser-generated NPs are proven to be useful for the analysis of selected drugs, with exceptionally good results for fentanyl monitoring in a broad range of concentrations.

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Section: Quantification Resultsmentioning

confidence: 99%

Fiber Laser-Generated Silver-109 Nanoparticles for Laser Desorption/Ionization Mass Spectrometry of Illicit Drugs

Krupa,

Nizioł

2024

J. Am. Soc. Mass Spectrom.

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“…2019 DART-HRMS followed by multivariate statistical analysis to infer the sources of heroin samples seized in China [ 134 ]; electrochemical strategies to detect heroin in street samples without the use of electrode modifications [ 135 ]; 2020 HPLC-MS/MS method for detection and quantification of the main alkaloids in heroin [ 136 ]; 2021 development of an HPLC-MS/MS method for the quantification of the main alkaloids in heroin [ 137 ]; ATR FT-IR method for classification and determination of the concentration range of illicit heroin in seized samples [ 138 ].…”

Section: Routine and Improved Analyses Of Abused Substancesmentioning

confidence: 99%

Interpol Review of Drug Analysis 2019-2022

Love

Jones

2023

Forensic Science International: Synergy

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“…Gas chromatography (GC) coupled to flame ionization detector (FID) or mass spectrometry (MS) is the most used technique in this framework due to its extreme reliability and simplicity [14][15][16][17][18]. In recent years, liquid chromatography-tandem mass spectrometry (LC-MS/MS) has represented a powerful tool for the simultaneous detection of several illicit substances, mainly because of the possibility of coupling with dilute and shoot sample preparation [19][20][21][22][23][24]. Following the principle of "less sample handling", this allows for the minimization of sample manipulation and the speeding up of the entire sample preparation procedure.…”

Section: Introductionmentioning

confidence: 99%

From the Streets to the Judicial Evidence: Determination of Traditional Illicit Substances in Drug Seizures by a Rapid and Sensitive UHPLC-MS/MS-Based Platform

et al. 2022

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According to the 2021 World Drug Report, around 275 million people use drugs of abuse, and 36 million people suffer from addiction, fostering a thriving market for illicit substances. In Italy, 30,083 people were reported to the Judicial Authority for offenses in violation of the Italian Law D.P.R. 309/1990. These offences are sentenced after a qualitative–quantitative analysis of seized materials. Given the large quantity of seized drugs and the need to perform accurate analytical determinations, Italian forensic laboratories struggle to complete analyses in a short time, delaying the entire reporting process needed to achieve sentencing. For this purpose, an UHPLC-MS/MS-based platform was developed at the University of Milano-Bicocca to support law-enforcement authorities. Software was designed to easily manage street seizure acquisition, documentation registration, and sampling. A sensitive UHPLC-MS/MS method was fully validated for the quantification of the traditional illicit substances (cocaine, heroin, 6-MAM, morphine, amphetamine, methamphetamine, MDMA, ketamine, GHB, GBL, LSD, trans-∆9-THC, and THCA) at the ppb level. The final report is relayed to the Prefecture in 3–4 days, even within 24 h for urgent requests. The platform allows for semi-automatic data handling to minimize erroneous results for an accurate report generation by standardized procedures.

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Rapid Determination of the Primary Alkaloids in Illicit Heroin by High-Performance Liquid Chromatography with Tandem Mass Spectrometry (HPLC–MS/MS)

Cited by 7 publications

References 18 publications

Fiber Laser-Generated Silver-109 Nanoparticles for Laser Desorption/Ionization Mass Spectrometry of Illicit Drugs

Fiber Laser-Generated Silver-109 Nanoparticles for Laser Desorption/Ionization Mass Spectrometry of Illicit Drugs

Interpol Review of Drug Analysis 2019-2022

From the Streets to the Judicial Evidence: Determination of Traditional Illicit Substances in Drug Seizures by a Rapid and Sensitive UHPLC-MS/MS-Based Platform

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