Rapid diagnosis and precision treatment of
            <i>Helicobacter pylori</i>
            infection in clinical settings

Umar, Zeeshan; Tang, Jia-Wei; Marshall, Barry J.; Tay, Alfred Chin Yen; Wang, Liang

doi:10.1080/1040841x.2024.2364194

Critical Reviews in Microbiology

2024

DOI: 10.1080/1040841x.2024.2364194

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Rapid diagnosis and precision treatment of Helicobacter pylori infection in clinical settings

Zeeshan Umar,

Jia-Wei Tang,

Barry J. Marshall

et al.

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Cited by 5 publications

References 240 publications

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Drug resistance of urease-positive bacteria other than Helicobacter pylori and distribution of urease genes in patients with gastritis

Amiri,

Goli,

Gholami

et al. 2024

Gene Reports

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Drug resistance of urease-positive bacteria other than Helicobacter pylori and distribution of urease genes in patients with gastritis

Amiri,

Goli,

Gholami

et al. 2024

Gene Reports

View full text Add to dashboard Cite

Application of Fourier transform infrared spectroscopy to exhaled breath analysis for detecting helicobacter pylori infection

Qiu,

Liao,

Tan

et al. 2024

Sci Rep

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Helicobacter pylori ( H. pylori ) is one of the most globally prevalent bacteria, closely associated with gastrointestinal diseases such as gastric ulcers and chronic gastritis. Current clinical methods primarily involve Carbon-13 and Carbon-14 urea breath test , both carrying potential safety risks. Fourier-transform infrared (FTIR) spectroscopy can detect human exhaled gases, which may change under disease conditions. This preliminary study aims to explore the application value of FTIR-based breath analysis in detecting H. pylori infection, providing theoretical basis and clinical references for new clinical detection methods. A cross-sectional survey was conducted from August 2021 to May 2022 at Renmin Hospital of Wuhan University. Breath samples were collected before and half an hour after ingesting unlabeled urea. Gas samples were analyzed using FTIR breath spectra. Individual exhalation spectral data after deducting baseline spectral data were used as the basis for the training and test sets through K-center clustering algorithm. Results: A total of 278 samples were collected (63 H. pylori i nfection cases, 215 healthy controls). There were no statistically significant differences in general data (age, gender, smoking history, alcohol consumption history, comorbidities, etc.) between the two groups. The predictive model was successfully established, with recognition rates of 94.12%, 98.39%, and 91.30% for the training set, test set, and validation set, respectively. Exhaled gas analysis based on Fourier-transform infrared spectroscopy has the potential to diagnose H. pylori infection.

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Helicobacter pylori Antimicrobial Susceptibility Testing-Guided Eradication Therapy in the Southeast Region of China: A Retrospective Study

Ma,

Fang,

Wang

et al. 2024

IDR

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Background and Aim Antibiotic resistance of Helicobacter pylori is increasing worldwide, lowering its efficacy in eradication therapy and posing a serious threat to human health. This study evaluated H. pylori resistance to antibiotics in the southeast region of China and explored factors related to eradication failure guided by antimicrobial susceptibility testing (AST). Methods In this retrospective study, patients who tested positive underwent gastroscopy, and H. pylori infection was confirmed by histological staining and H. pylori culture. We determined the rate of H. pylori antibiotic resistance, success rate of AST-guided eradication therapy, and risk factors associated with treatment failure. Results Among the 210 enrolled patients, 188 (89.5%) had successful cultures, and 183 (87.1%) underwent AST. The most common antibiotic resistance was to metronidazole and clarithromycin (89.6%), followed by levofloxacin (68.3%), and amoxicillin (14.2%). Furazolidone (3.0%) and tetracycline (0.5%) showed relatively low resistance rates. There were no statistically significant differences in the rates of resistance to MET, LEV, or AMX between naive and non-naive patients. However, CLA resistance rates in non-naive patients were significantly higher than those in naive patients. The overall success rate of AST-guided therapy was high and showed no significant difference between first-line and rescue therapy. Sex, age, prior therapy, and proton pump inhibitors (PPIs) or potassium-competitive acid blockers (P-CABs) use were not significantly associated with an increased risk of eradication failure in AST-guided therapy.

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Rapid diagnosis and precision treatment of Helicobacter pylori infection in clinical settings

Cited by 5 publications

References 240 publications

Drug resistance of urease-positive bacteria other than Helicobacter pylori and distribution of urease genes in patients with gastritis

Drug resistance of urease-positive bacteria other than Helicobacter pylori and distribution of urease genes in patients with gastritis

Application of Fourier transform infrared spectroscopy to exhaled breath analysis for detecting helicobacter pylori infection

Helicobacter pylori Antimicrobial Susceptibility Testing-Guided Eradication Therapy in the Southeast Region of China: A Retrospective Study

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