Rapid dilation of arterioles with single contraction of hamster skeletal muscle

VanTeeffelen, Jurgen W. G. E.; Segal, Steven S.

doi:10.1152/ajpheart.00197.2005

Cited by 78 publications

(112 citation statements)

References 43 publications

(124 reference statements)

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“…An important observation in the present study was that dilation often followed the first or second contraction, as noted by other authors using a variety of preparations (2,4,20,44). However, old males required approximately twice as long to begin dilating (Fig.…”

Section: Discussionsupporting

confidence: 81%

Advancing age produces sex differences in vasomotor kinetics during and after skeletal muscle contraction

Bearden

2007

American Journal of Physiology-Regulatory, Integrative and Comp

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Little is known of the vasomotor responses of skeletal muscle arterioles during and following muscle contraction. We hypothesized that aging leads to impaired arteriolar responses to muscle contraction and recovery. Nitric oxide (NO) availability, which is age dependent, has been implicated in components of these kinetics. Therefore, we also hypothesized that changes in the kinetics of vascular responses are associated with the NO pathway. Groups were young (3 mo), old (24 mo), endothelial NO synthase knockout (eNOS−/−), and NG-nitro-l-arginine (l-NA)-treated male and female C57BL/6 mice. The kinetics of vasodilation during and following 1 min of contractions of the gluteus maximus muscle were recorded in second-order (regional distribution) and third-order (local control) arterioles. Baseline, peak (during contraction), and maximal diameters (pharmacological) were not affected by age or sex. The kinetics of dilation and recovery were not different between males and females at the young age. There was a significant slowing of vasodilation at the onset of contractions (∼2-fold; P < 0.05) and a significant speeding of recovery (∼5-fold; P < 0.05) in old males vs. old females and vs. young eNOS−/−, and l-NA did not affect the kinetics at the onset of muscle contraction. eNOS−/− mimicked the rapid recovery of old males in second-order arterioles; acute NO production (l-NA) explained ∼50% of this effect. These data demonstrate fundamental age-related differences between the sexes in the dynamic function of skeletal muscle arterioles. Understanding how youthful function persists in females but not males may provide therapeutic insight into clinical interventions to maintain dynamic microvascular control of nutrient supply with age.

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Section: Discussionsupporting

confidence: 81%

Advancing age produces sex differences in vasomotor kinetics during and after skeletal muscle contraction

Bearden

2007

American Journal of Physiology-Regulatory, Integrative and Comp

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“…It has been well established in a number of independent laboratories and a number of different experimental models, including in vivo human forearm contractions (5,6,23,46,48), in situ electrically stimulated animal muscle (30,50), and in vitro isolated vessel preparations (9), that resistance vessels in skeletal muscle can dilate virtually immediately following a brief (as little as 0.3 s) muscle contraction. The time course of this dilation peaks approximately three to four cardiac cycles following contraction release (30,48).…”

Section: Mechanisms Localized To the Lower Limbs Explain Ioh On Risinmentioning

confidence: 99%

“…One such contribution could be rapid vasodilation in the contracting leg muscles with the effort of standing (54). In the past decade it has been firmly established both in human and animal model studies that skeletal muscle resistance vessels can dilate rapidly (within 1 s) in response to a single brief muscle contraction (9,18,29,36,46,48,50). The magnitude of this dilation is proportional to contraction intensity (46).…”

mentioning

confidence: 99%

Lower limb-localized vascular phenomena explain initial orthostatic hypotension upon standing from squat

Tschakovsky

Matusiak

Vipond

et al. 2011

American Journal of Physiology-Heart and Circulatory Physiology

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Tschakovsky ME, Matusiak K, Vipond C, McVicar L. Lower limb-localized vascular phenomena explain initial orthostatic hypotension upon standing from squat. Am J Physiol Heart Circ Physiol 301: H2102-H2112, 2011. First published August 19, 2011 doi:10.1152/ajpheart.00571.2011.-The cause(s) of initial orthostatic hypotension (transient fall in blood pressure within 15 s upon active rising) have not been established. We tested the hypothesis that this hypotension is due to local vascular phenomena in contracting leg muscles from the brief effort of standing up. Seventeen young healthy subjects (2 male and 15 female, 22.5 Ϯ 1.0 years) performed an active rise from resting squat after a 10-s squat, a 1-min squat, or a 5-min squat. Beat-by-beat arterial blood pressure, cardiac output, heart rate, and stroke volume (Finometer finger photoplethysmography) and right common femoral artery blood flow (Doppler and Echo ultrasound) were recorded. Data are means Ϯ SE. Quiet standing before squat represented baseline. Peak increases in lower limb and total vascular conductance (ml·min Ϫ1 ·mmHg Ϫ1 ) upon standing were not different within squat conditions (10-s squat, 50.0 Ϯ 12.4 vs. 44.3 Ϯ 5.0; 1-min squat, 54.7 Ϯ 9.2 vs. 50.5 Ϯ 4.5; 5-min squat, 67.4 Ϯ 13.7 vs. 58.8 Ϯ 3.9; all P Ͼ 0.574). Mean arterial blood pressure (in mmHg) fell to a nadir well below standing baseline in all conditions despite increases in cardiac output. The hypotension predicted by the increase in leg vascular conductance accounted for this hypotension [observed vs. predicted (in mmHg): 10-s squat, Ϫ17.1 Ϯ 2.1 vs. Ϫ18.3 Ϯ 5.5; 1-min squat, Ϫ22.0 Ϯ 3.8 vs. Ϫ25.3 Ϯ 4.9; 5-min squat, Ϫ28.3 Ϯ 4.0 vs. Ϫ29.2 Ϯ 6.7]. We conclude that rapid contraction induced dilation in leg muscles with the effort of standing, along with a minor potential contribution of elevated lower limb arterio-venous pressure gradient, outstrips compensatory cardiac output responses and is the cause of initial orthostatic hypotension upon standing from squat. blood pressure; syncope; muscle blood flow; muscle contraction; sympathetic withdrawal; cardiopulmonary baroreflex

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“…2 in Clifford and Hellsten (5)]. In fact, even a single muscle contraction produces a prompt increase in blood flow (1,7,14,26,36,39). There has been a debate over the last few decades about whether this rapid hyperemia is due to the muscle pump mechanism or to rapid vasodilation (5, 35).…”

mentioning

confidence: 99%

“…Experiments performed using the hamster cremaster (2,24) or retractor muscles (39) demonstrate that muscle contraction causes vasodilation of arterioles within 2-3 s of the onset of muscle contraction. Experiments performed in the human forearm (34,36) and dog hindlimb (26) indicate that the muscle pump cannot explain the entire hyperemic response to muscle contraction.…”

mentioning

confidence: 99%

Positional differences in reactive hyperemia provide insight into initial phase of exercise hyperemia

Jasperse

Shoemaker

Gray

et al. 2015

Journal of Applied Physiology

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Jasperse JL, Shoemaker JK, Gray EJ, Clifford PS. Positional differences in reactive hyperemia provide insight into initial phase of exercise hyperemia. J Appl Physiol 119: 569 -575, 2015. First published July 2, 2015; doi:10.1152/japplphysiol.01253.2013.-Studies have reported a greater blood flow response to muscle contractions when the limb is below the heart compared with above the heart, and these results have been interpreted as evidence for a skeletal muscle pump contribution to exercise hyperemia. If limb position affects the blood flow response to other vascular challenges such as reactive hyperemia, this interpretation may not be correct. We hypothesized that the magnitude of reactive hyperemia would be greater with the limb below the heart. Brachial artery blood flow (Doppler ultrasound) and blood pressure (finger-cuff plethysmography) were measured in 10 healthy volunteers. Subjects lay supine with one arm supported in two different positions: above or below the heart. Reactive hyperemia was produced by occlusion of arterial inflow for varying durations: 0.5 min, 1 min, 2 min, or 5 min in randomized order. Peak increases in blood flow were 77 Ϯ 11, 178 Ϯ 24, 291 Ϯ 25, and 398 Ϯ 33 ml/min above the heart and 96 Ϯ 19, 279 Ϯ 62, 550 Ϯ 60, and 711 Ϯ 69 ml/min below the heart (P Ͻ 0.05). Thus a standard stimulus (vascular occlusion) elicited different responses depending on limb position. To determine whether these differences were due to mechanisms intrinsic to the arterial wall, a second set of experiments was performed in which acute intraluminal pressure reduction for 0.5 min, 1 min, 2 min, or 5 min was performed in isolated rat soleus feed arteries (n ϭ 12). The magnitude of dilation upon pressure restoration was greater when acute pressure reduction occurred from 85 mmHg (mimicking pressure in the arm below the heart; 28.3 Ϯ 7.9, 37.5 Ϯ 5.9, 55.1 Ϯ 9.9, and 68.9 Ϯ 8.6% dilation) than from 48 mmHg (mimicking pressure in the arm above the heart; 20.8 Ϯ 4.8, 22.6 Ϯ 4.4, 31.2 Ϯ 5.8, and 49.2 Ϯ 7.1% dilation). These data support the hypothesis that arm position differences in reactive hyperemia are at least partially mediated by mechanisms intrinsic to the arterial wall. Overall, these results suggest the need to reevaluate studies employing positional changes to examine muscle pump influences on exercise hyperemia. muscle blood flow; muscle contraction; skeletal muscle pump; functional hyperemia AT THE ONSET OF DYNAMIC EXERCISE, there is a rapid increase in blood flow [30,31,41, and see Fig. 2 in Clifford and Hellsten (5)]. In fact, even a single muscle contraction produces a prompt increase in blood flow (1,7,14,26,36,39). There has been a debate over the last few decades about whether this rapid hyperemia is due to the muscle pump mechanism or to rapid vasodilation (5, 35).The muscle pump, as described by Laughlin (20), depends on an increased pressure gradient across the skeletal muscle vascular bed. Muscle contraction compresses the veins within the contracting muscle, expelling blood from the veins. ...

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Rapid dilation of arterioles with single contraction of hamster skeletal muscle

Cited by 78 publications

References 43 publications

Advancing age produces sex differences in vasomotor kinetics during and after skeletal muscle contraction

Advancing age produces sex differences in vasomotor kinetics during and after skeletal muscle contraction

Lower limb-localized vascular phenomena explain initial orthostatic hypotension upon standing from squat

Positional differences in reactive hyperemia provide insight into initial phase of exercise hyperemia

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