Rapid drug extraction from human whole blood using a modified QuEChERS extraction method

Prolonged hypotension induced by ingesting a topical minoxidil solution: analysis of minoxidil and its metabolites

“…Minoxidil levels in the serum and urine were extracted according to the QuEChERS method. 3 Unchanged minoxidil was analyzed in the serum and urine samples; minoxidil-O-glucuronide and minoxidil-N-O-sulfate were only analyzed in the urine samples. The serum concentrations of unchanged minoxidil at 4 and 16 h after ingestion were 4,994 and 33.90 ng/mL, respectively.…”

Rapid determination of disulfoton and its oxidative metabolites in human whole blood and urine using QuEChERS extraction and liquid chromatography–tandem mass spectrometry

“…On the other hand, SPE has high selectivity and the extract may contain fewer interfering substances than after LLE, but the procedure for extraction is relatively laborious. For that reason, we have recently devised a modified QuEChERS method for extraction of various types of drug, poison and their metabolite encountered in forensic toxicological analysis from human blood [17]. As its name indicates, the QuEChERS method has many advantages compared to conventional extraction methods [17][18][19][20][21][22].…”

Determination of Organochlorine Pesticides in Wildlife Liver and Serum Using Gas Chromatography Tandem Quadrupole Mass Spectrometry

“…Although the method has been widely used for pesticide analysis in a variety of food types, there have been few extensions to analysis of chemical residues in animal tissues [12,13]. The QuEChERS sample preparation method has been reported for the detection of pharmaceuticals in animal liver [14,15] and human whole blood [16]. To the best of the authors' knowledge, the method has not been applied to pesticide quantification in wildlife samples.…”