Rapid effective dose calculation for raster-scanning 4He ion therapy with the modified microdosimetric kinetic model (mMKM)

Kopp, Benedikt; Mein, Stewart; Tessonnier, Thomas; Besuglow, Judith; Harrabi, Semi; Heim, E; Abdollahi, Amir; Haberer, Thomas; Debus, Jürgen; Mairani, A.

doi:10.1016/j.ejmp.2020.11.028

Cited by 13 publications

(10 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Together with measured depth dose curves, the lateral dose distributions reported in this paper add another milestone in the development of the physical beam model for raster-scanned helium ions. With the MC model verified against measurements and particle spectra for biological equivalent dose calculation [24] simulated, the first clinical TPS for helium ions is finished. So, after the first clinical trials with helium ion beams at the LBNL observed positive outcomes, especially for patients with small tumors, such as uveal melanoma [2], we now have the means to restart helium ion therapy with raster scanning beam technology.…”

Section: Discussionmentioning

confidence: 99%

“…For simplicity, we chose beam angles of 0 °and 270 °and placed the isocenter in the center of the treatment volume. The biological dose optimization was based on the modified microdosimetric-kinetic model (mMKM) with an α/β-ratio of 2 Gy [24].…”

Section: Impact Of Beam Width Variation On Patient Treatmentmentioning

confidence: 99%

“…Similar to the HIT carbon ion commissioning [20][21][22][23], the set of data gathered for beam physics modeling in the RayStation TPS included laterally integrated depth dose curves (iDDDs), calibration of absolute dose per particle, and particle spectra [24]. However, while the collection of depth dose curves and absolute calibrations of helium ion dose was updated with respect to previous publications, lateral profiles in the air gap between the last beamline element and phantom had never been thoroughly investigated for raster-scanned helium ion beams.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Evolution of Lateral Dose Distributions of Helium Ion Beams in Air: From Measurement and Modeling to Their Impact on Treatment Planning

et al. 2022

View full text Add to dashboard Cite

To start clinical trials with the first clinical treatment planning system supporting raster-scanned helium ion therapy, a comprehensive database of beam characteristics and parameters was required for treatment room-specific beam physics modeling at the Heidelberg Ion-Beam Therapy Center (HIT). At six different positions in the air gap along the beam axis, lateral beam profiles were systematically measured for 14 initial beam energies covering the full range of available energies at HIT. The 2D-array of liquid-filled ionization chambers OCTAVIUS from PTW was irradiated by a pencil beam focused at the central axis. With a full geometric representation of HIT’s monitoring chambers and beamline elements in FLUKA, our Monte Carlo beam model matches the measured lateral beam profiles. A second set of measurements with the detector placed in a water tank was used to validate the adjustments of the initial beam parameters assumed in the FLUKA simulation. With a deviation between simulated and measured profiles below ±0.8 mm for all investigated beam energies, the simulated profiles build part of the database for the first clinical treatment planning system for helium ions. The evolution of beamwidth was also compared to similar simulations of the clinically available proton and carbon beam. This allows a choice of treatment modality based on quantitative estimates of the physical beam properties. Finally, we investigated the influence of beamwidth variation on patient treatment plans in order to estimate the relevance and necessary precision limits for lateral beam width models.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Impact Of Beam Width Variation On Patient Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Evolution of Lateral Dose Distributions of Helium Ion Beams in Air: From Measurement and Modeling to Their Impact on Treatment Planning

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Glioblastoma, pancreatic adenocarcinoma, and prostate adenocarcinoma patient cases previously treated at HIT were selected. Intensity modulated particle therapy (IMPT) reference plans were optimized in PRECISE with the same field arrangement as the clinical plans; however, instead of applying the clinical biological model (local effect model version 1), the mMKM was implemented with reference photon tissue fractionation parameter (α/β) x = 2 Gy, 31,38 (α/β) x = 5 Gy, 39 and (α/β) x = 3.1 Gy, 40 holding β x constant as in previous reports, 41 for the glioblastoma, pancreatic adenocarcinoma and prostate adenocarcinoma patient cases, respectively. For consistency in dosimetric evaluations, all plans were optimized with a prescription target dose of 3 GyRBE and constraints in normal tissues and OARs were not considered for the proof -of -concept study.…”

Section: -Field (2f) Sharc and Mit Treatment Planningmentioning

confidence: 99%

Spot‐scanning hadron arc (SHArc) therapy: A proof of concept using single‐ and multi‐ion strategies with helium, carbon, oxygen, and neon ions

et al. 2022

View full text Add to dashboard Cite

Purpose To present particle arc therapy treatments using single and multi‐ion therapy optimization strategies with helium (4He), carbon (12C), oxygen (16O), and neon (20Ne) ion beams. Methods and materials An optimization procedure and workflow were devised for spot‐scanning hadron arc therapy (SHArc) treatment planning in the PRECISE (PaRticle thErapy using single and Combined Ion optimization StratEgies) treatment planning system (TPS). Physical and biological beam models were developed for helium, carbon, oxygen, and neon ions via FLUKA MC simulation. SHArc treatments were optimized using both single‐ion (12C, 16O, or 20Ne) and multi‐ion therapy (16O+4He or 20Ne+4He) applying variable relative biological effectiveness (RBE) modeling using a modified microdosimetric kinetic model (mMKM) with (α/β)x values of 2, 5, and 3.1 Gy, respectively, for glioblastoma, pancreatic adenocarcinoma, and prostate adenocarcinoma patient cases. Dose, effective dose, linear energy transfer (LET), and RBE were computed with the GPU‐accelerated dose engine FRoG and dosimetric/biophysical attributes were evaluated in the context of conventional particle and photon‐based therapies (e.g., volumetric modulated arc therapy [VMAT]). Results All SHArc plans met the target optimization goals (3GyRBE) and demonstrated increased target conformity and substantially lower low‐dose bath to surrounding normal tissues than VMAT. SHArc plans using a singleion species (12C, 16O, or 20Ne) exhibited favorable LET distributions with the highest‐LET components centralized in the target volume, with values ranging from ∼80–170 keV/μm, ∼130–220 keV/μm, and ∼180–350 keV/μm for 12C, 16O, or 20Ne, respectively, exceeding mean target LET of conventional particle therapy (12C:∼55, 16O:∼75 20Ne:∼95 keV/μm). Multi‐ion therapy with SHArc delivery (SHArcMIT) provided a similar level of target LET enhancement as SHArc compared to conventional planning, however, with additional benefits of homogenous physical dose and RBE distributions. Conclusion Here, we demonstrate that arc delivery of light and heavy ion beams, using either a single‐ion species (12C, 16O, or 20Ne) or combining two ions in a single fraction (16O+4He or 20Ne+4He) affords enhanced physical and biological distributions (e.g., LET) compared with conventional delivery with photons or particle beams. SHArc marks the first single‐ and multi‐ion arc therapy treatment optimization approach using light and heavy ions.

show abstract

“…For helium ion therapy, the modified microdosimetric kinetic model (mMKM) was used. 34 In carbon ion therapy, the radiobiological local effect model (LEM) was employed. 35 Although the robust optimization concept is under investigation at HIT, it is not yet the clinical standard.…”

Section: Assessment Of Dlct Data-based Treatment Planning In Head Patientsmentioning

confidence: 99%

Dual‐layer spectral CT for proton, helium, and carbon ion beam therapy planning of brain tumors

Longarino

Tessonnier

Mein

et al. 2021

J Applied Clin Med Phys

View full text Add to dashboard Cite

Pretreatment computed tomography (CT) imaging is an essential component of the particle therapy treatment planning chain. Treatment planning and optimization with charged particles require accurate and precise estimations of ion beam range in tissues, characterized by the stopping power ratio (SPR). Reduction of range uncertainties arising from conventional CT-number-to-SPR conversion based on single-energy CT (SECT) imaging is of importance for improving clinical practice. Here, the application of a novel imaging and computational methodology using dual-layer spectral CT (DLCT) was performed toward refining patient-specific SPR estimates. A workflow for DLCT-based treatment planning was devised to evaluate SPR prediction for proton, helium, and carbon ion beam therapy planning in the brain. DLCT-and SECT-based SPR predictions were compared in homogeneous and heterogeneous anatomical regions. This study included eight patients scanned for diagnostic purposes with a DLCT scanner. For each patient, four different treatment plans were created, simulating tumors in different parts of the brain. For homogeneous anatomical regions, mean SPR differences of about 1% between the DLCT-and SECT-based approaches were found. In plans of heterogeneous anatomies, relative (absolute) proton range shifts of 0.6% (0.4 mm) in the mean and up to 4.4% (2.1 mm) at the distal fall-off were observed. In the investigated cohort, 12% of the evaluated organs-at-risk (OARs) presented differences in mean or maximum dose of more than 0.5 Gy (RBE) and up toThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

show abstract

Rapid effective dose calculation for raster-scanning 4He ion therapy with the modified microdosimetric kinetic model (mMKM)

Cited by 13 publications

References 42 publications

The Evolution of Lateral Dose Distributions of Helium Ion Beams in Air: From Measurement and Modeling to Their Impact on Treatment Planning

The Evolution of Lateral Dose Distributions of Helium Ion Beams in Air: From Measurement and Modeling to Their Impact on Treatment Planning

Spot‐scanning hadron arc (SHArc) therapy: A proof of concept using single‐ and multi‐ion strategies with helium, carbon, oxygen, and neon ions

Dual‐layer spectral CT for proton, helium, and carbon ion beam therapy planning of brain tumors

Contact Info

Product

Resources

About