Rapid entry to phenanthroindolizidine alkaloids via an acid-catalysed acyliminium ion-electrocyclization cascade

Abstract

A synthesis of phenanthroindolizidine alkaloids was achieved via an acid catalysed deprotection-condensation-electrocyclization cascade. This provided a concise synthesis of (±)-seco-antofine and (±)-septicine in 4 steps and with high overall yields.