Rapid Establishment of a Cold Chain Capacity of –60°C or Colder for the STRIVE Ebola Vaccine Trial During the Ebola Outbreak in Sierra Leone

Jusu, Morrison; Glauser, Geoffrey; Seward, Jane F.; Bawoh, Mohamed; Tempel, Judith; Friend, Michael; Littlefield, Daniel F.; Lahai, Michael; Jalloh, Hassan M; Sesay, Amara Bangali; Caulker, A F Y; Samai, Mohamed; Thomas, Vasavi; Farrell, Nicholas R.; Widdowson, Marc‐Alain

doi:10.1093/infdis/jix336

Cited by 35 publications

(39 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Maintaining specimens at the appropriate temperature is critical for laboratory sample integrity and testing results, particularly when cold temperatures are required [2,6,11]. Currently, polystyrene foam and injection molded plastic coolers are primarily being used in laboratory specimen transport systems.…”

Section: Discussionmentioning

confidence: 99%

“…Disrupting the cold chain during specimen transport activities can lead to specimen degradation and decrease the accuracy of testing or therapeutic potency [1][2][3][4]. Cold chain can be difficult to maintain during long trips or when traveling in areas with under-developed infrastructure [5][6][7]. Therefore, improving cold chain can decrease the number of specimens or medical supplies that arrives unfit for use.…”

Section: Introductionmentioning

confidence: 99%

“…The type and amount of coolant material used within the cooler during specimen transfers is another major factor affecting the cold chain system. Replenishing coolant material in low resource environments can be challenging due to unreliable electrical power (to support refrigerators and freezer units) and longer transit times due to poor road infrastructure transportation networks [5,6,8,9]. Therefore, it is necessary to find coolants that can cool for long transport times.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Analysis and modeling of coolants and coolers for specimen transportation

et al. 2020

View full text Add to dashboard Cite

Maintaining cold chain while transporting medical supplies and samples is difficult in remote settings. Failure to maintain temperature requirements can lead to degraded sample quality and inaccuracies in sample analysis. We performed a systematic analysis on different types of transport coolers (polystyrene foam, injection-molded, and rotational molded) and transport coolants (ice, cold packs, frozen water bottles) frequently in use in many countries. Polystyrene foam coolers stayed below our temperature threshold (6˚C) longer than almost all other types of coolers, but were not durable. Injection-molded coolers were durable, but warmed to 6˚C the quickest. Rotational molded coolers were able to keep temperatures below our threshold for 24 hours longer than injection molded coolers and were highly durable. Coolant systems were evaluated in terms of cost and their ability to maintain cold temperatures. Long lasting commercial cold packs were found to be less cost effective and were below freezing for the majority of the testing period. Frozen plastic water bottles were found to be a reusable and economical choice for coolant and were only below freezing briefly. Finally, we modeled the coolers performance at maintaining internal temperatures below 6˚C and built a highly accurate linear model to predict how long a cooler will remain below 6˚C. We believe this data may be useful in the planning and design of specimen transportation systems in the field, particularly in remote or resource limited settings.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Analysis and modeling of coolants and coolers for specimen transportation

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Temperature monitoring is mandatory in cold chain applications for the production, storage, distribution, and transportation of perishable, but life-critical products, such as foods, blood products, and vaccines [1,2,3,4]. The temperature range for the food cold chain is commonly from −20 to +15 °C [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…For blood products, such as fresh frozen plasma, the cold chain needs to maintain a low temperature under −25 °C. Temperature control for the vaccine cold chain is even more stringent [3], and some special vaccines, such as the anti-Ebola vaccine, may need a low temperature of −60 °C [4].…”

Section: Introductionmentioning

confidence: 99%

A 0.0014 mm2 150 nW CMOS Temperature Sensor with Nonlinearity Characterization and Calibration for the −60 to +40 °C Measurement Range

Yang

Jiang

Wang

2019

Sensors

View full text Add to dashboard Cite

This work presents a complementary metal–oxide–semiconductor (CMOS) ultra-low power temperature sensor chip for cold chain applications with temperatures down to −60 °C. The sensor chip is composed of a temperature-to-current converter to generate a current proportional to the absolute temperature (PTAT), a current controlled oscillator to convert the current to a frequency signal, and a counter as the frequency-to-digital converter. Unlike the conventional linear error calibration method, the nonlinear error of the PTAT current under the low temperature range is fully characterized based on the device model files provided by the foundry. Simulation has been performed, which clearly shows the nonlinear model is much more accurate than the linear model. A nonlinear error calibration method, which requires only two-point calibration, is then proposed. The temperature sensor chip has been designed and fabricated in a 0.13 μm CMOS process, with a total active die area of 0.0014 mm2. The sensor only draws a 140 nA current from a 1.1 V supply, with the key transistors working in the deep subthreshold region. Measurement results show that the proposed nonlinear calibration can decrease the measurement error from −0.9 to +1.1 °C for the measurement range of −60 to +40 °C, in comparison with the error of −1.8 to +5.3 °C using the conventional linear error calibration.

show abstract

Inequitable access to Ebola vaccines and the resurgence of Ebola in Africa: A state of arts review

Abdul‐Rahman,

Lawal,

Meale

et al. 2023

Journal of Medical Virology

View full text Add to dashboard Cite

The Ebola virus, a member of the filoviridae family of viruses, is responsible for causing Ebola Virus Disease (EVD) with a case fatality rate as high as 50%. The largest EVD outbreak was recorded in West Africa from March 2013 to June 2016, leading to over 28 000 cases and 11 000 deaths. It affected several countries, including Nigeria, Senegal, Guinea, Liberia, and Sierra Leone. Until then, EVD was predominantly reported in remote villages in central and west Africa close to tropical rainforests. Human mobility, behavioral and cultural norms, the use of bushmeat, burial customs, preference for traditional remedies and treatments, and resistance to health interventions are just a few of the social factors that considerably aid and amplify the risk of transmission. The scale and persistence of recent ebola outbreaks, as well as the risk of widespread global transmission and its ability for bioterrorism, have led to a rethinking of public health strategies to curb the disease, such as the expedition of Ebola vaccine production. However, as vaccine production lags in the subcontinent, among other challenges, the risk of another ebola outbreak is likely and feared by public health authorities in the region. This review describes the inequality of vaccine production in Africa and the resurgence of EVD, emphasizing the significance of health equality.

show abstract

Rapid Establishment of a Cold Chain Capacity of –60°C or Colder for the STRIVE Ebola Vaccine Trial During the Ebola Outbreak in Sierra Leone

Abstract: ClinicalTrials.gov [NCT02378753] and Pan African Clinical Trials Registry [PACTR201502001037220].

Cited by 35 publications

References 11 publications

Analysis and modeling of coolants and coolers for specimen transportation

Analysis and modeling of coolants and coolers for specimen transportation

A 0.0014 mm2 150 nW CMOS Temperature Sensor with Nonlinearity Characterization and Calibration for the −60 to +40 °C Measurement Range

Inequitable access to Ebola vaccines and the resurgence of Ebola in Africa: A state of arts review

Contact Info

Product

Resources

About