Evolvable hardware allows generating circuits adapted to specific problems by using an evolutionary algorithm (EA). Dynamic partial reconfiguration of FPGA LUTs allows making the processing elements (PEs) of these circuits small and compact, thus allowing large scale circuits to be implemented in a small FPGA area. This facilitates the use of these techniques in embedded systems with limited resources.The improvement on resource-efficient implementation techniques has allowed increasing the size of processing architectures from a few PEs to several hundreds. However, these large sizes pose new challenges for the EA and the architecture, which may not be able to take full advantage of the computing capabilities of its PEs.In this article, two different topologies-systolic array (SA) and Cartesian genetic programming (CGP)-are scaled from small to large sizes and analyzed, comparing their behavior and efficiency at different sizes. Additionally, improvements on SA connectivity are studied.Experimental results show that, in general, SA is considerably more resource-efficient than CGP, needing up to 60% fewer FPGA resources (LUTs) for a solution with similar performance, since the LUT usage per PE is 5 times smaller. Specifically, 10×10 SA has better performance than 5×10 CGP, but uses 50% fewer resources.