Rapid eye movement sleep without atonia may help diagnose <scp>L</scp>ewy body disease in middle‐aged and older patients with somatic symptom disorder

Munechika, Takayuki; Fujishiro, Hiroshige; Okuda, Masato; Iwamoto, Kunihiro; Torii, Youta; Iritani, Shuji; Ozaki, Norio

doi:10.1111/psyg.12181

Cited by 8 publications

(2 citation statements)

References 51 publications

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“…In previous studies on patients with PD, constipation was already associated with the presence of RBD and depression . These non‐motor symptoms have been demonstrated to occur many years before the onset of motor symptoms of PD, and are referred to as a condition called ‘pre‐motor PD’ .…”

Section: Discussionmentioning

confidence: 99%

Constipation is not associated with dopamine transporter pathology in early drug‐naïve patients with Parkinson's disease

Pagano

Yousaf

Wilson

et al. 2017

Euro J of Neurology

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Section: Discussionmentioning

confidence: 99%

Constipation is not associated with dopamine transporter pathology in early drug‐naïve patients with Parkinson's disease

Pagano

Yousaf

Wilson

et al. 2017

Euro J of Neurology

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“…In DLB patients, the incidence of RBD was up to 76%, anticipating the emergence of DLB by several years ( 30 ). Takayuki et al showed a correlation between RBD and DLB ( 31 ). In early-onset DLB patients with RBD, Kasanuki K et al found a significant deterioration of the dopaminergic pathways ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

Characteristics of initial symptoms in patients with dementia with Lewy body disease

Fei

Wang

et al. 2022

Front. Neurol.

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BackgroundDementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia. Although DLB is characterized by fluctuating cognitive impairment, some symptoms may appear before cognitive impairment, including rapid eye movement, sleep behavior disorder (RBD), psychiatric symptoms, autonomic symptoms, Parkinson's symptoms, etc. Therefore, DLB may be misdiagnosed as other diseases in its early stage.ObjectiveThis study aimed to investigate the characteristics of initial symptoms of DLB, which could potentially offer essential clues for the earliest diagnosis of this disorder.MethodsA total of 239 patients with probable DLB who visited the cognitive impairment outpatient department of Tianjin Huanhu Hospital from September 2015 to March 2021 were consecutively enrolled. We retrospectively evaluated the initial symptoms of all included participants. The time of onset of initial symptoms was also assessed.ResultsThe most frequent initial symptom was memory loss (53.9%), followed by psychiatric symptoms (34.7%), RBD (20.9%), parkinsonism (15.1%), and autonomic symptoms (10.1%). Significant gender and age differences existed in the initial symptoms of patients with DLB.ConclusionsOur study elucidated the initial symptoms in patients with probable DLB. RBD was significantly more reported by men than by women, whereas women showed a higher incidence of visual and auditory hallucinations. A better understanding of the initial symptoms of DLB could lead to a more accurate diagnosis.

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Neurobiology of Sleep-Related Movements

et al. 2020

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Rapid eye movement sleep without atonia may help diagnose Lewy body disease in middle‐aged and older patients with somatic symptom disorder

Cited by 8 publications

References 51 publications

Constipation is not associated with dopamine transporter pathology in early drug‐naïve patients with Parkinson's disease

Constipation is not associated with dopamine transporter pathology in early drug‐naïve patients with Parkinson's disease

Characteristics of initial symptoms in patients with dementia with Lewy body disease

Neurobiology of Sleep-Related Movements

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