Rapid Ferroelectric-Photoexcited Bacteria-Killing of Bi4Ti3O12/Ti3C2Tx Nanofiber Membranes

Wang, Zhiying; Li, Jianfang; Qiao, Yuqian; Liu, Xiangmei; Zheng, Yufeng; Li, Zhaoyang; Shen, Jie; Zhu, Shengli; Jiang, Hui; Liang, Yanqin; Cui, Zhenduo; Chu, Paul K.; Wu, Shuilin

doi:10.1007/s42765-022-00234-8

Cited by 48 publications

(18 citation statements)

References 48 publications

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“…For example, nanofiber membranes specifically designed for efficient photocatalysis show high efficacy in eliminating common infectious bacteria Escherichia coli and Staphylococcus aureus . [ 45 ] The benefits of this type of material are its form as a membrane and its potential for tunability. The state of the material allows for standardized coating of implants during manufacturing, simplifying the implantation and treatment process.…”

Section: Discussionmentioning

confidence: 99%

Photodynamic Therapy Minimally Affects HEMA‐DMAEMA Hydrogel Viscoelasticity

Willis

Trevino

Nguyen

et al. 2023

Macromolecular Bioscience

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Soft matter implants are a rapidly growing field in medicine for reconstructive surgery, aesthetic treatments, and regenerative medicine. Though these procedures are efficacious, all implants carry risks associated with microbial infection which are often aggressive. Preventative and responsive measures exist but are limited in applicability to soft materials. Photodynamic therapy (PDT) presents a means to perform safe and effective antimicrobial treatments in proximity to soft implants. HEMA‐DMAEMA hydrogels are prepared with the photosensitizer methylene blue included at 10 and 100 µM in solution used for swelling over 2 or 4 days. Thirty minutes or 5 h of LED illumination at is then used for PDT‐induced generation of reactive oxygen species in direct contact with hydrogels to test viable limits of treatment. Frequency sweep rheological measurements reveal minimal overall changes in terms of loss modulus and loss factor but a statistically significant drop in storage modulus for some PDT doses, though within the range of controls and biological variation. These mild impacts suggest the feasibility of PDT application for infection clearing in proximity to soft implants. Future investigation with additional hydrogel varieties and current implant models will further detail the safety of PDT in implant applications.

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Section: Discussionmentioning

confidence: 99%

Photodynamic Therapy Minimally Affects HEMA‐DMAEMA Hydrogel Viscoelasticity

Willis

Trevino

Nguyen

et al. 2023

Macromolecular Bioscience

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“…According to previously reported literature, MoS 2 was synthesized by a hydrothermal method. , Appropriate amounts of Na 2 MoO 4 ·2H 2 O and CH 4 N 2 S were sonicated to form a solution, which was heated at 200 °C for 24 h. Ti 3 C 2 T x was prepared by two-step etching and stripping way using Ti 3 AlC 2 as the raw material and LiF and concentrated hydrochloric acid as the etching agent, which was gentler compared with direct etching with hydrofluoric acid. , First, 20 mL of concentrated hydrochloric acid was slowly poured into a beaker and sealed with cling film. Two grams of LiF was weighed in two portions and slowly poured into the beaker so that LiF was completely dissolved in the concentrated hydrochloric acid.…”

Section: Experimental Methodsmentioning

confidence: 99%

Interfacial and Defect Polarization Enhanced Microwave Noninvasive Therapy for Staphylococcus aureus-Infected Chronic Osteomyelitis

Jin,

Liu,

Zheng

et al. 2023

ACS Nano

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Chronic osteomyelitis (COM), is a long-term, constant, and intractable disease mostly induced by infection from the invasion of Staphylococcus aureus (S. aureus) into bone cells. Here, we describe a highly effective microwave (MW) therapeutic strategy for S. aureus-induced COM based on the in situ growth of interfacial oxygen vacancy-rich molybdenum disulfide (MoS2)/titanium carbide (Ti3C2T x ) MXene with oxygen-deficient titanium dioxide (TiO2‑x) on Ti3C2T x (labeled as HU-MoS2/Ti3C2T x ) by producing reactive oxygen species (ROS) and heat. HU-MoS2/Ti3C2T x produced heat and ROS, which could effectively treat S. aureus-induced COM under MW irradiation. The underlying mechanism determined by density functional theory (DFT) and MW vector network analysis was that HU-MoS2/Ti3C2T x formed a high-energy local electric field under MW irradiation, consequently generating more high-energy free electrons to pass and move across the interface at a high speed and accelerate by the heterointerface, which enhanced the charge accumulation on both sides of the interface. Moreover, these charges were captured by the oxygen species adsorbed at the HU-MoS2/Ti3C2T x interface to produce ROS. MoS2 facilitated multiple reflections and scattering of electromagnetic waves as well as enhanced impedance matching. Ti3C2T x enhanced the conduction loss of electromagnetic waves, while functional groups induced dipole polarization to enhance attenuation of MW.

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“…Bacteria were collected from the infection site after 24 h of treatment and resuspended in PBS. Then, 10 μL of the above resuspension was coated on an agar plate, and the antibacterial activity was evaluated from the number of colonies. − …”

Section: Methodsmentioning

confidence: 99%

Injectable Nanocomposite Hydrogels with the NIR-Triggered Low-Temperature Photothermal Effect and Low-Dose Antibiotic Release

Xiao

Yuan

2023

ACS Appl. Polym. Mater.

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Bacterial infection threatens tissue wound healing in clinical practice, so it is essential to construct a safe and efficient antibacterial dressing. In this work, an injectable efficient antibacterial hydrogel is designed to treat bacterial infection disease through the near-infrared (NIR)-triggered low-temperature photothermal effect (below 50 °C) and low-dose antibiotic synergistic therapy. A series of nanocomposite hydrogels (COTC) for antibacterial therapy are synthesized by Schiff base consisting of carboxymethyl chitosan (CMCS), oxidized sodium alginate (OSA), tobramycin (TOB), and cobalt sulfide nanoparticles. The released TOB is controlled in a low dosage through the degradation of Schiff base between TOB and OSA. The biocompatibility assays prove that the hydrogels have excellent biocompatibility. Under NIR irradiation for 10 min, the COTC hydrogels display efficient and controllable photothermal properties (48 °C) and excellent antibacterial efficiency of 99.92 and 99.73% against Escherichia coli and Staphylococcus aureus, respectively. Therefore, these injectable synergistic antibacterial COTC hydrogels exhibit excellent potential for infected wound healing as wound dressing.

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Rapid Ferroelectric-Photoexcited Bacteria-Killing of Bi4Ti3O12/Ti3C2Tx Nanofiber Membranes

Abstract: In this study, an antibacterial nanofiber membrane [polyvinylidene fluoride/Bi 4 Ti 3 O 12 /Ti 3 C 2 T x (PVDF/BTO/Ti 3 C 2 T x )] is fabricated using an electrostatic spinning process, in which the self-assembled BTO/Ti 3 C 2 T x … Show more

Cited by 48 publications

References 48 publications

Photodynamic Therapy Minimally Affects HEMA‐DMAEMA Hydrogel Viscoelasticity

Photodynamic Therapy Minimally Affects HEMA‐DMAEMA Hydrogel Viscoelasticity

Interfacial and Defect Polarization Enhanced Microwave Noninvasive Therapy for Staphylococcus aureus-Infected Chronic Osteomyelitis

Injectable Nanocomposite Hydrogels with the NIR-Triggered Low-Temperature Photothermal Effect and Low-Dose Antibiotic Release

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