As the digital health industry becomes increasingly competitive, companies must integrate science cross-functionally to drive innovation and differentiation. However, many companies face significant challenges in effectively leveraging science across their organization. This commentary explores the common obstacles digital health companies encounter when integrating science, including limited C-suite understanding, siloed structures, resource constraints, change resistance, and value demonstration challenges. We provide practical strategies for overcoming each challenge, such as educating leadership on science's strategic importance, fostering cross-functional collaboration, prioritizing high-impact initiatives, facilitating open dialogue, and quantifying science's measurable impact. By proactively addressing these hurdles through targeted solutions, companies can successfully integrate science across teams and functions. Effective cross-functional science integration will enable companies to leverage scientific insights, drive product innovation, build credibility through evidence-based outcomes, and ultimately gain a competitive advantage in the rapidly evolving digital health landscape. Strong scientific leadership that champions integration through clear communication, strategic prioritization, and cultural buy-in is essential for achieving long-term success.