Rapid growth rate is associated with poor prognosis in cutaneous squamous cell carcinoma

Cañueto, Javier; Martín-Vallejo, Javier; Cardeñoso-Álvarez, Ester; Fernández‐López, Emilia; Pérez-Losada, Jesús; Román-Curto, Concépción

doi:10.1111/ced.13570

Cited by 24 publications

(21 citation statements)

References 25 publications

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“…However, only since the landmark paper by Lipsker, Engel, Cribier, Velten, and Hedelin (2007), in 2007, melanoma have been largely accepted to be subdivided into slow growing or fast growing subtypes with both types corresponding to specific epidemiological, morphological, and metastatic characteristics. While studies mainly focused on the growth kinetics of melanoma growth and its implications for prognosis and management, there are currently very few studies assessing this aspect in the realm of cSCC (Cañueto et al, 2018). Contrary to what we support with this report, Kricker et al (2014) in their study about basal cell carcinoma and cSCC growth rates did not find an overall correlation between time and size of cSCC.…”

Section: Discussioncontrasting

confidence: 99%

“…The first recognizing ROG as important biological marker in melanoma was Clark et al (1969). While studies mainly focused on the growth kinetics of melanoma growth and its implications for prognosis and management, there are currently very few studies assessing this aspect in the realm of cSCC (Cañueto et al, 2018). While studies mainly focused on the growth kinetics of melanoma growth and its implications for prognosis and management, there are currently very few studies assessing this aspect in the realm of cSCC (Cañueto et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Cañueto et al proposed a ROG of 4 mm/month, measured on H&E-stained slides, as a reliable cutoff point for high risk cSCC, likely associated with poor outcome (Cañueto et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

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Rate of growth—A novel surrogate marker for high‐risk cutaneous squamous cell carcinoma? A case report and review of the literature

Giuffrida

Conforti

Schmid

et al. 2019

Dermatologic Therapy

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Cutaneous squamous cell carcinoma (cSCC) is one of the most common nonmelanoma skin cancer worldwilde, with a more invasive growth pattern and higher potential to metastatize than basal cell carcinoma. Although several risk factors have been linked to a high metastatic potential of cSCC, no widely accepted classification system for this common subtype of cancer exists. Herein we report an emblematic case of rapidly growing and metastatic cSCC and discuss the rate of growth of the tumour (ROG) as novel prognostic high risk surrogate marker.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Rate of growth—A novel surrogate marker for high‐risk cutaneous squamous cell carcinoma? A case report and review of the literature

Giuffrida

Conforti

Schmid

et al. 2019

Dermatologic Therapy

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“…Rapid growth rate as a risk factor has been reported in small series with consensus by multidisciplinary guideline committees. 9,26…”

Section: Etiology and Rapid Growthmentioning

confidence: 99%

Mohs Surgery versus Standard Local Excision for Basal Cell Carcinoma, Squamous Cell Carcinoma, and Melanoma Skin Cancer

Johnson

Smith

2020

Facial Plast Surg

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Basal cell carcinoma, squamous cell carcinoma, and melanoma represent the three most common skin cancers that occur on the face. The most common surgical treatments for facial skin cancers are Mohs' surgery and standard local excision. The effective utilization of either of these techniques is based on tumor and patient risk stratification incorporating known risk factors for occult invasion and local recurrence, combined with patient comorbidities, expectations, and desires. Best available evidence highlights multiple and consistent risk factors for each specific skin cancer type, and dictate local control rates reported in the literature. Recognizing gaps in the literature, we compare and review surgical treatment guidelines and data for standard local excision versus Mohs' surgery for cutaneous nonmelanoma and melanoma skin cancer. This article serves as a resource for optimal therapeutic decision making for surgical management of skin cancer on the face.

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“…Standardized measurements for presence or absence of actinic histopathologic change, tissue invasion and mitotic index were not available in this population and this limitation may have provided over‐ or underestimates of prevalence or severity for the assessed histopathologic factors. However, a systematic approach to assessment of future biopsies with inclusion of depth of invasion in millimetres, tumour subtype, perineural invasion and Ki‐67 may help to discern whether these criteria are reflective of high risk tumours in dogs as has been documented in people . Tissue invasiveness was found to be associated with histopathologic features of actinic change, but this may have been biased because the actinic designation required a microscopic description whereas the tissue invasion was not uncommonly mentioned in the final diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Clinical features and outcome of dermal squamous cell carcinoma in 193 dogs (1987‐2017)

Willcox

Marks

Ueda

et al. 2019

Vet Comparative Oncology

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Squamous cell carcinoma (SCC) is a frequently recognized dermal tumour in dogs and has been described as a common pathology induced by solar ultraviolet radiation exposure. Little has been published about this neoplasm with regard to clinical features and outcome in dogs. This retrospective study included 193 dogs from a single institution histopathologically diagnosed with SCC of the dermis. Thirty‐eight percent of all dogs had documented histopathologic actinic change. The overall median survival time was 1004 days, with the population demonstrating actinic change associated with a significantly longer survival time (median 1359 days, range 16‐3530 days) compared to dogs without actinic change (median 680 days, range 16‐3066 days) and this achieved significance on multivariate analysis (hazard ratio 0.42, 95% confidence interval 0.193‐0.930, P = 0.032). These data demonstrate increased survival of dogs with SCC demonstrating actinic change over those with non‐actinic SCCs, and purports long‐term survival for these animals. Dogs received a variety of treatment approaches as a retrospective study, and future prospective studies will be necessary to investigate whether adjunct therapies such as radiation or chemotherapy offer improvement in survival for dermal SCC in the dog.

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Rapid growth rate is associated with poor prognosis in cutaneous squamous cell carcinoma

Abstract: We consider a GR of 4 mm/month as the cutoff point that distinguishes between rapid- and slow-progressing tumours and, more importantly, to identify a subset of high-risk cSCCs.

Cited by 24 publications

References 25 publications

Rate of growth—A novel surrogate marker for high‐risk cutaneous squamous cell carcinoma? A case report and review of the literature

Rate of growth—A novel surrogate marker for high‐risk cutaneous squamous cell carcinoma? A case report and review of the literature

Mohs Surgery versus Standard Local Excision for Basal Cell Carcinoma, Squamous Cell Carcinoma, and Melanoma Skin Cancer

Clinical features and outcome of dermal squamous cell carcinoma in 193 dogs (1987‐2017)

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