Rapid hemostatic antibacterial self-gelling powder based on methacryloylsulfonyl betaine and quaternized carboxymethyl chitosan

Deng, Junxia; Wang, Zhen; Xing, Jinfeng

doi:10.1016/j.jmbbm.2023.106079

Cited by 9 publications

(2 citation statements)

References 61 publications

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“…QCCS was synthesized by modifying carboxymethyl chitosan based on our previous work . In brief, 1 g of carboxymethyl chitosan was dissolved in 20 mL of deionized water, and then GTA was added into the mixture solution.…”

Section: Methodsmentioning

confidence: 99%

“…The micromorphology, mechanical properties, and tissue adhesion properties of the hydrogel were characterized, its in vitro biological evaluation, cytotoxicity, hemocompatibility, and coagulation properties were also evaluated, and its in vivo coagulation property was finally evaluated using a mouse hepatorrhagia model. 50 In brief, 1 g of carboxymethyl chitosan was dissolved in 20 mL of deionized water, and then GTA was added into the mixture solution. The reaction proceeded for 24 h at 60 °C, and the product was precipitated in absolute ethanol and centrifuged at 3000 rpm for 5 min.…”

Section: Introductionmentioning

confidence: 99%

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An Organic–Inorganic Hybrid Hydrogel Based on Chitosan for Effective Hemostasis

Song,

Yu,

Deng

et al. 2024

ACS Appl. Polym. Mater.

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The ideal hemostatic dressing should not only achieve the effect of hemostasis but also maintain a suitable moist environment and sufficient physical and mechanical strength and avoid secondary injury to the wound. Here, a stretchable, adhesive, and antibacterial hydrogel (SAQH) for wound hemostasis is facilely prepared by photopolymerization under green LED irradiation, in which acrylamide (AAM) and methacryloylethylsulfobetaine (SBMA) are used as the skeleton and quaternized carboxymethyl chitosan (QCCS) is used as the procoagulant component. The introduction of the macromolecular cross-linking agent methacryloyl hyaluronic acid (HA-GMA) enhances biocompatibility and avoids the addition of small molecular toxic cross-linking agents. The introduction of inorganic nanoparticle hydroxyapatite (HAP) into the hydrogel system not only improves the mechanical properties of the polymer network but also releases calcium ions from HAP to achieve a good coagulation-promoting effect. SAQH hydrogels have excellent mechanical properties (the maximum stress can reach 237 kPa), good adaptability, sufficient tissue adhesion, and effective antibacterial properties. In the mouse liver injury model, hydrogels can adhere to the bleeding site to reduce blood loss, and they will not cause secondary bleeding when removed. This research develops a potential hemostatic hydrogel with broad applicable prospects.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An Organic–Inorganic Hybrid Hydrogel Based on Chitosan for Effective Hemostasis

Song,

Yu,

Deng

et al. 2024

ACS Appl. Polym. Mater.

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A Self‐Gelling Powder Directly Co‐Assembled by Natural Small Molecules for Traumatic Brain Injury

Yang,

Luo,

Song

et al. 2024

Adv Funct Materials

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The prognosis for traumatic brain injury (TBI) depends largely on prompt hemostasis and effective pharmacologic interventions. Natural all‐small‐molecule self‐gelling powder, integrating the advantages of self‐assembled small‐molecule hydrogels and powders, is expected to provide timely and effective prehospital management of TBI. However, the synthesis and application of natural all‐small‐molecule self‐gelling powder is still uncharted territory. In this study, an all‐small‐molecule co‐assembled MGF‐H3BO3‐RUT (MBR) self‐gelling powder is fabricated through the co‐assembly of mangiferin (MGF) and rutin (RUT) in H3BO3/NaOH aqueous solution. Both compounds can bind with boric acid, leading to co‐assembling into hydrogels through hydrogen‐bonding interactions and π–π stacking. MBR self‐gelling powder is then obtained by drying the as‐prepared hydrogels, thus integrating hemostasis and pharmacodynamics into one. Remarkably, it displays robust regeneration capabilities, while retaining excellent self‐healing properties and injectability after drying‐hydration cycles. Moreover, MBR self‐gelling powder not only achieves rapid effective hemostasis but also attenuates conspicuously cerebral edema and inflammatory response after TBI by in situ spraying, exhibiting notable neuroprotective effects without discernible toxic side effects. This study provides a novel assembly strategy and application form for self‐assembled gel materials originating from natural small molecules, offering promising avenues for the treatment of TBI in the acute phase.

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Swift Covalent Gelation Coupled with Robust Wet Adhesive Powder: A Novel Approach for Acute Massive Hemorrhage Control in Dynamic and High‐Pressure Wound Environments

Chen,

Wang,

Pan

et al. 2024

Small

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The quest for efficient hemostatic agents in emergency medicine is critical, particularly for managing massive hemorrhages in dynamic and high‐pressure wound environments. Traditional self‐gelling powders, while beneficial due to their ease of application and rapid action, fall short in such challenging conditions. To bridge this gap, the research introduces a novel self‐gelling powder that combines ultrafast covalent gelation and robust wet adhesion, presenting a significant advancement in acute hemorrhage control. This ternary system comprises ε‐polylysine (ε‐PLL) and 4‐arm polyethylene glycol succinyl succinate (4‐arm‐PEG‐NHS) forming the hydrogel framework. Na2HPO4 functions as the “H+ sucker” to expedite the amidation reaction, slashing gelation time to under 10 s, crucial for immediate blood loss restriction. Moreover, PEG chains' hydrophilicity facilitates efficient absorption of interfacial blood, increasing the generated hydrogel's cross‐linking density and strengthens its tissue bonding, thereby resulting in excellent mechanical and wet adhesion properties. In vitro experiments reveal the optimized formulation's exceptional tissue compliance, procoagulant activity, biocompatibility and antibacterial efficacy. In porcine models of heart injuries and arterial punctures, it outperforms commercial hemostatic agent Celox, confirming its rapid and effective hemostasis. Conclusively, this study presents a transformative approach to hemostasis, offering a reliable and potent solution for the emergency management of massive hemorrhage.

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Rapid hemostatic antibacterial self-gelling powder based on methacryloylsulfonyl betaine and quaternized carboxymethyl chitosan

Cited by 9 publications

References 61 publications

An Organic–Inorganic Hybrid Hydrogel Based on Chitosan for Effective Hemostasis

An Organic–Inorganic Hybrid Hydrogel Based on Chitosan for Effective Hemostasis

A Self‐Gelling Powder Directly Co‐Assembled by Natural Small Molecules for Traumatic Brain Injury

Swift Covalent Gelation Coupled with Robust Wet Adhesive Powder: A Novel Approach for Acute Massive Hemorrhage Control in Dynamic and High‐Pressure Wound Environments

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