Rapid Imaging of Infections With a Monoclonal Antibody Fragment (LeukoScan)

Becker, Wolfgang; Palestro, Christopher J.; Winship, Jay; Feld, Thomas; Pinsky, Carl M.; Wolf, F.; Goldenberg, David M.

doi:10.1097/00003086-199608000-00033

Cited by 90 publications

(37 citation statements)

References 12 publications

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“…Several monoclonal antibodies reactive with antigens expressed on granulocytes (NCA (noncrossreactive antigen), CD15, CD66 and CD67) have been developed. At least four anti-granulocyte antibodies have been tested for infection imaging: anti-NCA-95 IgG (BW250/183) [15], anti-CD67 IgG (AK-47) [16], anti-NCA-90 Fab' (Immu-MN3, leukoscan ® : anti-CD66) [17,18,19] and anti-CD15 (LeuTec ® ) [20,21]. Each of these anti-granulocyte antibodies labeled with 99m Tc allowed accurate delineation of infection and inflammation.…”

Section: Labeled Antigranulocyte Antibodiesmentioning

confidence: 99%

“…In addition, antibody fragments show faster blood clearance and may thus provide earlier diagnosis. The 99m Tclabeled antigranulocyte Fab'-fragment (Leukoscan ® ) has been registered as an infection imaging agent [17]. Recently, a 99m Tc-labeled anti-CD15 IgM monoclonal antibody has shown promising results in patients with equivocal appendicitis [23].…”

Section: Labeled Antigranulocyte Antibodiesmentioning

confidence: 99%

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Radiopharmaceuticals for scintigraphic imaging of infection and inflammation

Boerman¹,

Dams²,

Oyen³

et al. 2001

Inflammation Research

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Scintigraphic imaging of infection and inflammation is a powerful diagnostic tool in the management of patients with infectious or inflammatory diseases. Most infectious and inflammatory foci can be visualized accurately with radiolabeled autologous leukocytes. However, preparation of this radiopharmaceutical is laborious and requires the handling of potentially contaminated blood. Nowadays, a few radiopharmaceuticals are available that could replace radiolabeled leukocytes, such as: 67Ga-citrate, 99mTc-IgG and 99mTc-labeled antigranulocyte antibody preparations. Furthermore, various agents labeled with 99mTc are currently developed for this application: chemotactic peptides, cytokines and liposomes. Here, the characteristics and the diagnostic potential of established and experimental radiopharmaceuticals for infection and inflammation imaging are reviewed.

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Section: Labeled Antigranulocyte Antibodiesmentioning

confidence: 99%

Section: Labeled Antigranulocyte Antibodiesmentioning

confidence: 99%

Radiopharmaceuticals for scintigraphic imaging of infection and inflammation

Boerman¹,

Dams²,

Oyen³

et al. 2001

Inflammation Research

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“…We therefore believe that the results of our study accurately reflect the ability to image infection with MAB in chronic post-traumatic osteomyelitis. The published studies reporting the use of 99mTc-HMPAO-labelled leucocytes for the detection of chronic osteomyelitis calculated values for sensitivity (83%-93%) and specificitiy (78%-100%) that suggest superiority over IS [7,10,23,24]. Until now, however, no comparative study that proves this hypothesis has been performed in this field of application.…”

Section: Discussionmentioning

confidence: 99%

“…Two recently published reports have presented encouraging results using a 99mTc-antigranulocyte monoclonal antibody fragment [10,24]. The advantages over MAB are the shortened imaging time and a negligible HAMA response rate.…”

Section: Discussionmentioning

confidence: 99%

Chronic complicated osteomyelitis of the appendicular skeleton: Diagnosis with technetium-99m labelled monoclonal antigranulocyte antibody-immunoscintigraphy

et al. 1997

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Abstract. Chronic post-traumatic osteomyelitis (OM) represents a particular challenge for nuclear medicine and radiology since clinical and biochemical parameters are frequently unreliable. The aim of this study was to investigate the value of combined bone scan (BS) and immunoscintigraphy (IS) with technetium-99m labelled monoclonal antigranulocyte antibody (MAB) in patients with suspected chronic OM of the appendicular skeleton. Twenty-four patients (17 females and 7 males) with suspected chronic post-traumatic OM were evaluated with three-phase BS/99mTc-MAB-IS. The final diagnosis was established by means of bone culture and histology in 19 cases and clinical follow-up in five cases. The studies were reviewed by two independent and experienced observers; the interobserver agreement was calculated by kappa statistics. The sensitivity, specificity and accuracy of BS alone were 92%, 18% and 58%, respectively. Combined BS/99mTc-MAB-IS had a sensitivity, specificity and accuracy of 84%, 72% and 79%, respectively. Of 24 studies, 11 were true-positive, two false-negative, eight true-negative and three false-positive. Two patients presented with unexpected ectopic haematopoietic bone marrow in the appendicular skeleton that caused falsepositive results. A high degree of interobserver agreement was found (~:=0.85). It is concluded that combined BS/99mTc-MAB-IS represents a very sensitive and reproducible method with an acceptable specificity for the investigation of chronic OM. Problems may occur in the differentiation of low-grade OM from aseptic inflammation. Another problem is ectopic marrow that may occur in the appendicular skeleton due to a chronic inflammatory stimulus. A former intramedullary intervention in the femur with displacement of haematopoietic marrow may also lead to an ectopic location.

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“…Thus, at present, the production of diagnostic kits "LeukoScan®" for the technetium-99m generators, which are fragments of antibodies to granulocytes (Fab '), has been established. The mechanism of accumulation of 99mTc-Fab' in the pathological focus is mainly due to their interaction with surface receptors of granulocytes and non-specific diffusion into the lesion due to increased vascular permeability [60].…”

mentioning

confidence: 99%

Modern Opportunities of Radionuclide Methods for Diagnosis of Inflammatory Processes in the Myocardium

Сазонова¹,

Ilyushenkova²,

Lishmanov³

2017

Rejr

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he review is devoted to the radionuclide diagnostics of inflammatory processes in the myocardium. The work briefly describes the main radiopharmaceuticals proposed for visualization of inflammation in cardiology, compares their scintigraphic characteristics, parameters of sensitivity and specificity. The authors discuss unsolved problems, as well as the prospects of nuclear medicine in terms of diagnosing inflammatory diseases. Literature was searched using electronic bibliographic databases, such as Medline, PubMed, E-library.

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Rapid Imaging of Infections With a Monoclonal Antibody Fragment (LeukoScan)

Cited by 90 publications

References 12 publications

Radiopharmaceuticals for scintigraphic imaging of infection and inflammation

Radiopharmaceuticals for scintigraphic imaging of infection and inflammation

Chronic complicated osteomyelitis of the appendicular skeleton: Diagnosis with technetium-99m labelled monoclonal antigranulocyte antibody-immunoscintigraphy

Modern Opportunities of Radionuclide Methods for Diagnosis of Inflammatory Processes in the Myocardium

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