Rapid immunochromatographic test for serum granulysin is useful for the prediction of Stevens-Johnson syndrome and toxic epidermal necrolysis

Immunological mechanisms of epidermal damage in toxic epidermal necrolysis

“…Granulysin, which permits cell-mediated cytotoxicity without direct cell-to-cell contact [33], is responsible for the poor cell infiltration of TEN. Serum granulysin levels were increased in TEN patients 2-4 days before the appearance of mucous membrane disorders [34,35]. The resulting cell membrane disruption induces mitochondrial damage, leading to cell death.…”

Towards the development of mechanism-based biomarkers to diagnose drug hypersensitivity

“…Nonetheless, different groups have demonstrated that the serum concentration of sFasL and granulysin, measured independently, are higher in patients with SJS/TEN 2 to 4 days before the onset of the reaction, determined by the appearance of mucosal lesions, returning to basal levels at the resolution stage in most of the patients. 97 The concentration of these biomarkers is transitory in serum, but the levels remain higher in cells isolated from the patients even after 3 years when stimulated with the culprit drug in vitro. 97 The concentration of these biomarkers is transitory in serum, but the levels remain higher in cells isolated from the patients even after 3 years when stimulated with the culprit drug in vitro.…”

Postoperative Stevens-Johnson syndrome secondary to piperacillin-tazobactam: A case report

“…Given the severe nature of SJS/TEN and its initial presentation, a rapid diagnostic test to predict SJS versus benign drug reaction is being developed [13]. Patients who are diagnosed with SJS have increased systemic levels of FasL as well as increased granulysin levels.…”