Rapid induction of colonic adenocarcinoma in mice exposed to benzo[a]pyrene and dextran sulfate sodium

Hakura, Atsushi; Seki, Yasutaka; Sonoda, Jiro; Hosokawa, Satoru; Aoki, Toyohiko; Suganuma, Akiyoshi; Kerns, William; Tsukidate, Kazuo

doi:10.1016/j.fct.2011.07.057

Cited by 28 publications

(25 citation statements)

References 25 publications

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“…The mechanism by which tobacco smoking has a modified effect on the association between NQO1 C609T variant and colorectal cancer risk may involve decreased NQO1 enzyme activity, leading to increased levels of BP metabolites in smokers and thus leading to an increased risk of CRC. Animal and human studies have suggested that dietary BP increased the risk of CRC [39, 40]. …”

Section: Discussionmentioning

confidence: 99%

Systematic review/Meta-analysis NQO1 C609T polymorphism and colorectal cancer susceptibility: a meta-analysis

Zheng¹,

Wang²,

Chai³

2014

aoms

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IntroductionA few studies have reported an association between NADP(H): quinine oxidoreductase 1 (NQO1) C609T polymorphism and susceptibility to colorectal cancer (CRC). However, the results were inconsistent rather than conclusive. We performed a meta-analysis to examine this association in various populations.Material and methodsEligible articles were identified by a search of several databases up until June 30, 2013. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of the association.ResultsOverall, 14 case-control studies with 4,461 cases and 5,474 controls were included in this meta-analysis. The results indicated that the NQO1 C609T polymorphism was significantly associated with CRC susceptibility (summary ORs (95% CIs): 1.30 (1.07–1.59) for CT vs. CC, 1.64 (1.15–2.33) for TT vs. CC, 1.34 (1.10–1.64) for TT/CT vs. CC, and 1.43 (1.10–1.87) for TT vs. CT/CC). Subgroup analyses indicated that the T allele was significantly associated with CRC susceptibility in both Asians and Caucasians, and was also observed in high quality studies and hospital-based case-control studies. Specifically, we found a positive association between the NQO1 C609T polymorphism and CRC susceptibility in smokers, but not in non-smokers.ConclusionsThe results of this meta-analysis suggest that the NQO1 C609T polymorphism significantly contributes to increased susceptibility to CRC in both Asians and Caucasians.

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Section: Discussionmentioning

confidence: 99%

Systematic review/Meta-analysis NQO1 C609T polymorphism and colorectal cancer susceptibility: a meta-analysis

Zheng¹,

Wang²,

Chai³

2014

aoms

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“…Several experimental investigations in mice demonstrated that exposure to B[a]P or in combination of with dextran sulfate sodium induced incidence of adenomas and adenocarcinomas in the colon of APC Min and CD2F1 mice (Hakura et al, 2011;Diggs et al, 2013;Mantey et al, 2014).…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Benzo(a)pyrene induces oxidative stress, pro-inflammatory cytokines, expression of nuclear factor-kappa B and deregulation of wnt/beta-catenin signaling in colons of BALB/c mice

Ajayi

Adedara

Farombi

2016

Food and Chemical Toxicology

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“…orally for 5 consecutive days (153,154) to 2 weeks (155) also registered high rates of mutation in colon. Hakura et al (156) reported multiple polyps in a dextran sulfate sodium (DSS)-induced colitis model of Crj:CD2F1 mice treated with 125 mg BaP/kg bw/day for 5 days followed by 4% DSS for 2 weeks.…”

Section: Pathologymentioning

confidence: 99%

“…In a colitis mouse model mentioned above, Hakura et al (156) reported many modular papillary or polypoid masses in colon. These masses were classified as tubular adenomas or adenocarcinomas.…”

Section: Pathologymentioning

confidence: 99%

Polycyclic Aromatic Hydrocarbons and Digestive Tract Cancers: A Perspective

Diggs

Huderson

Harris

et al. 2011

Journal of Environmental Science and Health, Part C

241

107

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Cancers of the colon are most common in the Western world. In majority of these cases, there is no familial history and sporadic gene damage seems to play an important role in the development of tumors in the colon. Studies have shown that environmental factors, especially diet, play an important role in susceptibility to GI tract cancers. Consequently, environmental chemicals that contaminate food or diet during its preparation becomes important in the development of GI cancers. Polycyclic aromatic hydrocarbons (PAHs) are one such family of ubiquitous environmental toxicants. These pollutants enter the human body through consumption of contaminated food, drinking water, inhalation of cigarette smoke, automobile exhausts, and contaminated air from occupational settings. Among these pathways, dietary intake of PAHs constitutes a major source of exposure in humans. Although many reviews and books on PAHs and their ability to cause toxicity and breast or lung cancer have been published, aspects on contribution of diet, smoking and other factors towards development of digestive tract cancers and strategies to assess risk from exposure to PAHs have received much less attention. This review, therefore, focuses on dietary intake of PAHs in humans, animal models, and cell cultures used for GI cancer studies along with epidemiological findings. Bioavailability and biotransformation processes, which influence the disposition of PAHs in body and the underlying causative mechanisms of GI cancers, are also discussed. The existing data gaps and scope for future studies is also emphasized. This information is expected to stimulate research on mechanisms of sporadic GI cancers caused by exposure to environmental carcinogens.

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Rapid induction of colonic adenocarcinoma in mice exposed to benzo[a]pyrene and dextran sulfate sodium

Cited by 28 publications

References 25 publications

Systematic review/Meta-analysis NQO1 C609T polymorphism and colorectal cancer susceptibility: a meta-analysis

Systematic review/Meta-analysis NQO1 C609T polymorphism and colorectal cancer susceptibility: a meta-analysis

Benzo(a)pyrene induces oxidative stress, pro-inflammatory cytokines, expression of nuclear factor-kappa B and deregulation of wnt/beta-catenin signaling in colons of BALB/c mice

Polycyclic Aromatic Hydrocarbons and Digestive Tract Cancers: A Perspective

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