Rapid Induction of Long-Lasting Systemic and Mucosal Immunity via Thermostable Microneedle-Mediated Chitosan Oligosaccharide-Encapsulated DNA Nanoparticles

Li, Minchao; Yang, Li; Wang, Congcong; Cui, Mingting; Wen, Ziyu; Liao, Zhiheng; Han, Zirong; Zhao, Yangguo; Lang, Bing; Chen, Hongzhong; Qian, Jun; Shu, Yuelong; Zeng, Xiaowei; Sun, Caijun

doi:10.1021/acsnano.3c09521

Cited by 9 publications

(2 citation statements)

References 46 publications

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“…The team prepared oligosaccharide-encapsulated nanoparticle vaccine with potential ability to induce strong mucosal immunity, 57 , 58 and further developed a thermostable microneedle-mediated nanoparticle vaccine, which effectively induced a rapid and long-lasting systemic and mucosal immunity with enhanced magnitude, polyfunctionality, and persistence in mice. 59 …”

Section: Vaccine Research and Development Sub-sessionmentioning

confidence: 99%

The 2 ^nd China Vaccinology Integrated Innovation & Teaching Development Conference: Promoting the construction of vaccinology discipline system

Chen,

Shu,

Zheng

et al. 2024

Human Vaccines & Immunotherapeutics

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The 2 nd China Vaccinology Integrated Innovation & Teaching Development Conference was held in Sun Yat-sen University, Shenzhen, 18–19, November 2023. Over 200 participants in the field of Vaccinology gathered together to address challenges and issues relevant to vaccine education and training courses, research, and public health programs in China. The conference themed “Promoting the Integrated and Innovative Development of Vaccinology through Collective Efforts.” The conference was organized by the China Association of Vaccine (CAV) and hosted by Vaccinology Education Professional Committee of CAV, and School of Public Health (Shenzhen), Sun Yat-sen University. Other partners included the Medical Virology Branch of the Chinese Medical Association, the editorial committee of the Chinese Journal of Preventive Medicine, Human Vaccines & Immunotherapeutics, and the People’s Medical Publishing House. The 1 st conference was held in Hangzhou, in October 2020.

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Section: Vaccine Research and Development Sub-sessionmentioning

confidence: 99%

The 2 ^nd China Vaccinology Integrated Innovation & Teaching Development Conference: Promoting the construction of vaccinology discipline system

Chen,

Shu,

Zheng

et al. 2024

Human Vaccines & Immunotherapeutics

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“…Surprisingly, the MN vaccine elicited superior systemic and mucosal T-cell immunity, demonstrating enhanced magnitude, polyfunctionality, and persistence. Notably, the MN vaccine can be stored at room temperature for at least one month without a significant decrease in its immunogenicity …”

Section: Precision Vaccination Using Defined Nanovaccinesmentioning

confidence: 99%

Precision Nanovaccines for Potent Vaccination

Liu,

Chen,

Yang

et al. 2024

JACS Au

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Compared with traditional vaccines, nanoparticulate vaccines are especially suitable for delivering antigens of proteins, peptides, and nucleic acids and facilitating lymph node targeting. Moreover, apart from improving pharmacokinetics and safety, nanoparticulate vaccines assist antigens and molecular adjuvants in crossing biological barriers, targeting immune organs and antigen-presenting cells (APC), controlled release, and cross-presentation. However, the process that stimulates and orchestrates the immune response is complicated, involving spatiotemporal interactions of multiple cell types, including APCs, B cells, T cells, and macrophages. The performance of nanoparticulate vaccines also depends on the microenvironments of the target organs or tissues in different populations. Therefore, it is necessary to develop precise nanoparticulate vaccines that accurately regulate vaccine immune response beyond simply improving pharmacokinetics. This Perspective summarizes and highlights the role of nanoparticulate vaccines with precise size, shape, surface charge, and spatial management of antigen or adjuvant for a precision vaccination in regulating the distribution, targeting, and immune response. It also discusses the importance of the rational design of nanoparticulate vaccines based on the anatomical and immunological microstructure of the target tissues. Moreover, the target delivery and controlled release of nanovaccines should be taken into consideration in designing vaccines for achieving precise immune responses. Additionally, it shows that the nanovaccines remodel the suppressed tumor environment and modulate various immune cell responses which are also essential.

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Near‐Infrared Triggered Biodegradable Microneedle Patch for Controlled Macromolecule Drug Release

Cheng,

Yang,

Han

et al. 2024

Macromolecular Bioscience

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Transdermal drug delivery of macromolecule drugs has attracted significant attention due to the advantage of convenience and biocompatibility. However, the practical usage of it is limited by the low delivery efficiency and poor drug absorption. To develop an efficient, safe, and controllable transdermal delivery method, the near‐infrared (NIR) triggered calcium sulfate and gelatin biodegradable composite microneedle (MN) patches have been developed. The MN patches were fabricated by polydimethylsiloxane (PDMS) molds, and the structure data could be adjusted by changing the molds. Such an MN patch could release both macro and micro molecule drugs. After loaded with photothermal converter IR780, which could transfer energy of light to heat, the release of macromolecule drugs in MNs could be controlled by applying NIR irradiation. The control effect could be enhanced by spraying 1‐tetradecanol (TD) coating and optimizing the ratio (weight) of gelatin and calcium sulfate to 2:6. Besides, the MN patch could deliver drugs through the skin barrier, and the process could be controlled by NIR. Moreover, the insulin‐loaded MN patch exhibits some therapeutic effects on healthy mice. This work suggests that biodegradable MNs could achieve controllable drug delivery and potentially be applied in individual treatment via transdermal ingestion.This article is protected by copyright. All rights reserved

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Rapid Induction of Long-Lasting Systemic and Mucosal Immunity via Thermostable Microneedle-Mediated Chitosan Oligosaccharide-Encapsulated DNA Nanoparticles

Cited by 9 publications

References 46 publications

The 2 ^nd China Vaccinology Integrated Innovation & Teaching Development Conference: Promoting the construction of vaccinology discipline system

The 2 ^nd China Vaccinology Integrated Innovation & Teaching Development Conference: Promoting the construction of vaccinology discipline system

Precision Nanovaccines for Potent Vaccination

Near‐Infrared Triggered Biodegradable Microneedle Patch for Controlled Macromolecule Drug Release

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Rapid Induction of Long-Lasting Systemic and Mucosal Immunity via Thermostable Microneedle-Mediated Chitosan Oligosaccharide-Encapsulated DNA Nanoparticles

Cited by 9 publications

References 46 publications

The 2 nd China Vaccinology Integrated Innovation & Teaching Development Conference: Promoting the construction of vaccinology discipline system

The 2 nd China Vaccinology Integrated Innovation & Teaching Development Conference: Promoting the construction of vaccinology discipline system

Precision Nanovaccines for Potent Vaccination

Near‐Infrared Triggered Biodegradable Microneedle Patch for Controlled Macromolecule Drug Release

Contact Info

Product

Resources

About

The 2 ^nd China Vaccinology Integrated Innovation & Teaching Development Conference: Promoting the construction of vaccinology discipline system

The 2 ^nd China Vaccinology Integrated Innovation & Teaching Development Conference: Promoting the construction of vaccinology discipline system