Rapid Infusion of Fish Oil–Based Emulsion in Infants Does Not Appear to be Associated With Fat Overload Syndrome

Abstract

Rapid infusion of a fish oil-based emulsion in 6 infants were well tolerated. No patients developed signs or symptoms of fat overload syndrome.

Nine Cases of Unintentional Rapid Infusion of Lipid Emulsion in Children: Root Cause Analysis and Changes to Practice

“…Similar incidents of rapid infusion of lipid emulsions have been reported previously, including incidents involving the amino acids and lipids being administered at “switched” rates 2 3. Fat overload syndrome is a potential consequence of rapid lipid infusion and may have serious consequences including respiratory failure and metabolic acidosis and spontaneous haemorrhage 4.…”

Impact of Providing a Combination Lipid Emulsion Compared With a Standard Soybean Oil Lipid Emulsion in Children Receiving Parenteral Nutrition

“…The type of LE and phospholipid emulsifier used may affect the rate of hydrolysis of triglycerides 9 , 13 . Rapid infusion of lipids above the threshold for lipid hydrolysis may result in fat overload syndrome, which is associated with hypertriglyceridemia, respiratory distress, coagulopathies, thrombocytopenia, hepatomegaly, hyperbilirubinemia, and elevated liver enzymes 9 , 14 . PNALD is a potentially life‐threatening complication and may progress from steatosis to cholestasis, cholelithiasis, liver fibrosis, portal hypertension, and potentially result in end‐stage liver disease 2 .…”

Feasibility of Intermittent Fish Oil Infusions in Outpatients with Graft- Versus-Host Disease of the Digestive Tract

“…The hazards of transient hypertriglyceridemia (during a few hours) have not been well described; in a small group of infants, rapid infusions of a fish oil emulsion were well tolerated and no fat overload syndrome was observed [36]. Nevertheless, infusing fatty acid at a slower rate appears to be preferable.…”