Rapid initiation of guided bone regeneration driven by spatiotemporal delivery of IL-8 and BMP-2 from hierarchical MBG-based scaffold

Lin, Dan; Chai, Yanjun; Ma, Yifan; Duan, Bing; Yuan, Yuan; Liu, Changsheng

doi:10.1016/j.biomaterials.2017.11.011

Cited by 115 publications

(96 citation statements)

References 41 publications

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“…120 Multiple growth factors can also be exposed on the scaffold surface to promote new bone formation. 147 For example, FGF2 is favor of cell migration, whereas VEGF promotes vascularization at the defect site. Thus, incorporation of FGF2 and VEGF into biomaterial scaffolds not only promotes recruitment of endothelial stem cells and MSCs, but also facilitates the new blood vessel formation during bone regeneration.…”

Section: Controlled Release Of Active Chemical Components For Bone Tementioning

confidence: 99%

Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

2020

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Natural bone is a mineralized biological material, which serves a supportive and protective framework for the body, stores minerals for metabolism, and produces blood cells nourishing the body. Normally, bone has an innate capacity to heal from damage. However, massive bone defects due to traumatic injury, tumor resection, or congenital diseases pose a great challenge to reconstructive surgery. Scaffold-based tissue engineering (TE) is a promising strategy for bone regenerative medicine, because biomaterial scaffolds show advanced mechanical properties and a good degradation profile, as well as the feasibility of controlled release of growth and differentiation factors or immobilizing them on the material surface. Additionally, the defined structure of biomaterial scaffolds, as a kind of mechanical cue, can influence cell behaviors, modulate local microenvironment and control key features at the molecular and cellular levels. Recently, nano/micro-assisted regenerative medicine becomes a promising application of TE for the reconstruction of bone defects. For this reason, it is necessary for us to have in-depth knowledge of the development of novel nano/micro-based biomaterial scaffolds. Thus, we herein review the hierarchical structure of bone, and the potential application of nano/micro technologies to guide the design of novel biomaterial structures for bone repair and regeneration.

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Section: Controlled Release Of Active Chemical Components For Bone Tementioning

confidence: 99%

Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

2020

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“…With this spatiotemporal delivery system, IL‐8 and BMP‐2 induced a rapid and efficient stem cell recruitment and a “chondrogenic/osteogenic balance” at the first stage of endochondral ossification. The scaffold exhibited osteoconductivity, resulting in early extensive bone regeneration and a restauration of mechanical properties of the bone after 12 weeks in a rabbit model of radius large segmental defect …”

Section: Optimization Of Bioactive Glass Hybridsmentioning

confidence: 99%

Optimized Bioactive Glass: the Quest for the Bony Graft

Granel

Bossard

Nucke

et al. 2019

Adv Healthcare Materials

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Technological advances have provided surgeons with a wide range of biomaterials. Yet improvements are still to be made, especially for large bone defect treatment. Biomaterial scaffolds represent a promising alternative to autologous bone grafts but in spite of the numerous studies carried out on this subject, no biomaterial scaffold is yet completely satisfying. Bioactive glass (BAG) presents many qualifying characteristics but they are brittle and their combination with a plastic polymer appears essential to overcome this drawback. Recent advances have allowed the synthesis of organic–inorganic hybrid scaffolds combining the osteogenic properties of BAG and the plastic characteristics of polymers. Such biomaterials can now be obtained at room temperature allowing organic doping of the glass/polymer network for a homogeneous delivery of the doping agent. Despite these new avenues, further studies are required to highlight the biological properties of these materials and particularly their behavior once implanted in vivo. This review focuses on BAG with a particular interest in their combination with polymers to form organic–inorganic hybrids for the design of innovative graft strategies.

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“…Tissue engineering methods include the use of cell-seeded scaffolds to repair and replace damaged tissues, which are expected to be used to repair cartilage defects. [1][2][3][4] In order to support the specic differentiation of bone mesenchymal stem cells (BMSCs), it is very important to design scaffolds with proper structures, mechanical properties and drug loading abilities. [5][6][7] Among various biocompatible materials, collagen is an ideal candidate material for the preparation of cartilage tissue engineering scaffolds, [8][9][10] because it is a component of natural cartilage.…”

Section: Introductionmentioning

confidence: 99%

Sodium alginate/collagen composite multiscale porous scaffolds containing poly(ε-caprolactone) microspheres fabricated based on additive manufacturing technology

Liu

Huang

et al. 2020

RSC Adv.

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Rapid initiation of guided bone regeneration driven by spatiotemporal delivery of IL-8 and BMP-2 from hierarchical MBG-based scaffold

Cited by 115 publications

References 41 publications

Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

Optimized Bioactive Glass: the Quest for the Bony Graft

Sodium alginate/collagen composite multiscale porous scaffolds containing poly(ε-caprolactone) microspheres fabricated based on additive manufacturing technology

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