Rapid Integration Across Tonotopy by Individual Auditory Brainstem Octopus Cells

McGinley, Matthew J.

doi:10.1007/978-1-4614-8094-5_14

Cited by 1 publication

(1 citation statement)

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“…Biophysically, octopus cells have low input resistances near rest (~4MΩ), fast time constants (~200µs), and a large low-voltage-activated potassium conductance (~40nS at rest) that give these cells impressively narrow windows of coincidence detection on the order of 1 millisecond [8][9][10][11][12][13][14][15] . This combination of receiving ANF innervation across broad frequencies and their biophysical specializations establish octopus cells as spectrotemporal coincidence detectors that can reliably encode the timing of complex stimuli, such as the broadband transients found in speech and other natural sounds 12,16,17 . Fittingly, in vivo recordings from octopus cells demonstrate their ability to phase lock to broadband transients at rates up to 1kHz [18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

An Anatomical and Physiological Basis for Flexible Coincidence Detection in the Auditory System

Kreeger,

Honnuraiah,

Maeker

et al. 2024

Preprint

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SummaryCoincidence detection is a common neural computation that identifies co-occurring stimuli by integration of inputs. In the auditory system, octopus cells act as coincidence detectors for complex sounds that include both synchronous and sequenced combinations of frequencies. Octopus cells must detect coincidence on both the millisecond and submillisecond time scale, unlike the average neuron, which integrates inputs over time on the order of tens of milliseconds. Here, we show that octopus cell computations in the cell body are shaped by inhibition in the dendrites, which adjusts the strength and timing of incoming signals to achieve submillisecond acuity. This mechanism is crucial for the fundamental process of integrating the synchronized frequencies of natural auditory signals over time.

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