Rapid Intravenous Glyceryl Trinitrate in Ischemic Damage (RIGID) After Stroke: Rationale, Design and Protocol for a Prospective Randomized Controlled Trial
Abstract:Background: Despite intravenous thrombolysis and endovascular therapy for acute ischemic stroke (AIS), many survivors still have varying degrees of disability. Glyceryl trinitrate (GTN), a nitric oxide (NO) donor, has been previously reported to induce neuroprotection after AIS. The use of GTN to reduce brain damage after stroke remains yet to be elucidated. This study was designed to explore the safety, feasibility, and preliminary efficacy of intravenous administration of GTN after AIS.Methods: A prospective… Show more
“…The outcomes were evaluated by two blinded observers. Lastly, blinded independent investigators collected and analyzed group outcomes and information as described previously [ 21 , 22 ].…”
“…The outcomes were evaluated by two blinded observers. Lastly, blinded independent investigators collected and analyzed group outcomes and information as described previously [ 21 , 22 ].…”
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