Rapid method for the simultaneous analysis of hydrocortisone and clioquinol in topical preparations by high-performance liquid chromatography

Different spectrophotometric methods manipulating ratio spectra for the assay of hydrocortisone acetate and clioquinol in their topical preparation

“…The specificity was assessed by the analysis of binary mixtures containing different proportions of the drugs and the methods were shown to be specific as shown in Table 2. The proposed methods were applied for the determination of the cited drugs in Vioderm hydrocortisone cream and the results were compared statistically with the reported HPLC method [15] as shown in Table 3. The proposed methods for analysis of drugs in pure powder were also statistically compared to those of the official [5] and reported HPLC [10] methods showing no significant difference as presented in Table 4.…”

“…Several methods for the determination of the drugs have been reported in different dosage forms [7][8][9][10][11][12][13]. Literature survey revealed that HCA and CL binary mixture was determined by HPLC and TLC methods [14,15]. No spectrophotometric methods have been developed for the determination of both drugs simultaneously in different mixtures.…”

“…Statistical comparison between the results obtained by the proposed methods and the reported method[15] for the determination of HCA and CL, in pharmaceutical dosage form. The values in the parenthesis are the corresponding theoretical values of t and F at p = 0.05.…”

Pharmaceuticals and related drugs

“…During the current review period a new Journal dealing with pharmaceutical analysis was introduced (1) and several books published including: "A Textbook of Pharmaceutical Analysis" (4), "Progress in the Quality Control of Medicines" (6), "Modern Methods of Pharmaceutical Analysis", volumes 1 and 2 (17,18), "Instrumental Data for Drug Analysis" (11), and Volume 11 of a collective series concerned with individual compounds and their analytical profiles (8). A comprehensive review of the analysis of pharmaceutical compounds appeared.…”

Reverse-Phase High-Performance Liquid Chromatographic Determination of Halogenated 8-Hydroxyquinoline Compounds in Pharmaceuticals and Bulk Drugs

“…Polymethyl methacrylate has been used in surgery for over 30 years as a material for artificial bones (7). Implanted methyl methacrylate polymers appear to be well tolerated if the implants are monomer-free and under a certain threshold size (8).…”