Rapid microfluidic mixer utilizing sharp corner structures

Fan, Liang‐Liang; Zhu, Xiaoliang; Zhao, Hong; Zhe, Jiang; Zhao, Liang

doi:10.1007/s10404-017-1874-y

Cited by 26 publications

(15 citation statements)

References 26 publications

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“…The numerical model was validated by comparing its results with experimental results of Fan et al [ 26 ]. Simulations were conducted using the reported geometric parameters and fluid properties.…”

Section: Resultsmentioning

confidence: 99%

“…Asymmetric curvilinear microchannels can show better mixing performance than symmetric channels at Dean numbers ( K ) greater than 16.8, whereas symmetric channels achieve a higher mixing index than asymmetric curvilinear microchannel below the threshold value of K [ 25 ]. Fan et al presented a study on the use of sharp corners in series to improve mixing efficiency [ 26 ]. Alam et al presented a numerical study of straight and curved microchannels with circular obstacles that changed the flow pattern to achieve better performance than channels without obstacles [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Passive Mixing in a Serpentine Microchannel with Sinusoidal Side Walls

2017

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Sample mixing is difficult in microfluidic devices because of laminar flow. Micromixers are designed to ensure the optimal use of miniaturized devices. The present study aims to design a chaotic-advection-based passive micromixer with enhanced mixing efficiency. A serpentine-shaped microchannel with sinusoidal side walls was designed, and three cases, with amplitude to wavelength (A/λ) ratios of 0.1, 0.15, and 0.2 were investigated. Numerical simulations were conducted using the Navier–Stokes equations, to determine the flow field. The flow was then coupled with the convection–diffusion equation to obtain the species concentration distribution. The mixing performance of sinusoidal walled channels was compared with that of a simple serpentine channel for Reynolds numbers ranging from 0.1 to 50. Secondary flows were observed at high Reynolds numbers that mixed the fluid streams. These flows were dominant in the proposed sinusoidal walled channels, thereby showing better mixing performance than the simple serpentine channel at similar or less mixing cost. Higher mixing efficiency was obtained by increasing the A/λ ratio.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analysis of Passive Mixing in a Serpentine Microchannel with Sinusoidal Side Walls

2017

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“…For each image, the fluorescence intensity along the green lines marked in Figure 1 was extracted with the software to obtain intensity versus length profiles. To quantify the mixing degree, mixing index, M, was calculated as [34]…”

Section: Image Processingmentioning

confidence: 99%

Inertial Micromixing in Curved Serpentine Micromixers with Different Curve Angles

Alijani

Özbey

Karimzadehkhouei

et al. 2019

Fluids

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Micromixers are of considerable significance in many microfluidics system applications, from chemical reactions to biological analysis processes. Passive micromixers, which rely solely on their geometry, have the advantages of low cost and a less-complex fabrication process. Dean vortices seen in curved microchannels are one of the useful tools to enhance micromixing. In this study, the effects of curve angle on micromixing were experimentally investigated in three curved serpentine micromixers consisting of ten segments with curve angles of 180 ° , 230 ° and 280 ° , at Dean numbers between 12 and 87. To characterize and compare the performance of the micromixers, fluorescence intensity maps and mixing indices were utilized. Accordingly, the micromixer having segments with 280 ° curve angle had significantly higher mixing index values up to the Dean number 60 and outperformed the other two micromixers. This was due to the severe distortion of flow streamlines by Dean vortices and the occurrence of chaotic advection at lower Dean numbers. Beyond the Dean number of 70, no difference was observed in the performance of the micromixers and the mixing index at their outlets had the asymptotic value of 0.93 ± 0.02. Furthermore, the flow behavior of the micromixers was numerically simulated to provide further insight about the mixing phenomena.

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“…Through reasonable structure design, the chip channel with high mixing efficiency at low Reynolds number can be obtained [ 15 ]. Fan [ 16 ] developed a rapid microfluidic mixer utilizing sharp corner structures, it can be potentially used in the fluid mixing in variety of lab-on-a-chip applications. The preparation method of the chip also needs to be considered.…”

Section: Introductionmentioning

confidence: 99%

Development of Rapid and High-Precision Colorimetric Device for Organophosphorus Pesticide Detection Based on Microfluidic Mixer Chip

et al. 2021

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The excessive pesticide residues in cereals, fruit and vegetables is a big threat to human health, and it is necessary to develop a portable, low-cost and high-precision pesticide residue detection scheme to replace the large-scale laboratory testing equipment for rapid detection of pesticide residues. In this study, a colorimetric device for rapid detection of organophosphorus pesticide residues with high precision based on a microfluidic mixer chip was proposed. The microchannel structure with high mixing efficiency was determined by fluid dynamics simulation, while the corresponding microfluidic mixer chip was designed. The microfluidic mixer chip was prepared by a self-developed liquid crystal display (LCD) mask photo-curing machine. The influence of printing parameters on the accuracy of the prepared chip was investigated. The light source with the optimal wavelength of the device was determined by absorption spectrum measurement, and the relationship between the liquid reservoir depth and detection limit was studied by experiments. The correspondence between pesticide concentration and induced voltage was derived. The minimum detection concentration of the device could reach 0.045 mg·L−1 and the average detection time was reduced to 60 s. The results provide a theoretical and experimental basis for portable and high-precision detection of pesticide residues.

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Rapid microfluidic mixer utilizing sharp corner structures

Cited by 26 publications

References 26 publications

Analysis of Passive Mixing in a Serpentine Microchannel with Sinusoidal Side Walls

Analysis of Passive Mixing in a Serpentine Microchannel with Sinusoidal Side Walls

Inertial Micromixing in Curved Serpentine Micromixers with Different Curve Angles

Development of Rapid and High-Precision Colorimetric Device for Organophosphorus Pesticide Detection Based on Microfluidic Mixer Chip

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